دورية أكاديمية
The Anticancer Efficacy of Thiourea-Mediated Reduced Graphene Oxide Nanosheets against Human Colon Cancer Cells (HT-29).
| العنوان: | The Anticancer Efficacy of Thiourea-Mediated Reduced Graphene Oxide Nanosheets against Human Colon Cancer Cells (HT-29). |
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| المؤلفون: | Vimalanathan B; Crystal Growth Centre, Anna University, Chennai 600025, India., Vijaya JJ; Catalysis and Nanomaterials Research Laboratory, Department of Chemistry, Loyola College, Chennai 600034, India., Mary BCJ; Catalysis and Nanomaterials Research Laboratory, Department of Chemistry, Loyola College, Chennai 600034, India., Ignacimuthu S; Xavier Research Foundation, St. Xavier's College, Palayamkottai, Thirunelveli 627002, India., Daniel M; Department of Zoology, Loyola College, Chennai 600034, India., Jayavel R; Crystal Growth Centre, Anna University, Chennai 600025, India., Bououdina M; Department of Mathematics and Sciences, Faculty of Humanities and Sciences, Prince Sultan University, Riyadh 122001, Saudi Arabia., Bellucci S; INFN-Laboratori Nazionali di Frascati, Via E. Fermi 54, 00044 Frascati, Italy. |
| المصدر: | Journal of functional biomaterials [J Funct Biomater] 2022 Aug 27; Vol. 13 (3). Date of Electronic Publication: 2022 Aug 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101570734 Publication Model: Electronic Cited Medium: Print ISSN: 2079-4983 (Print) Linking ISSN: 20794983 NLM ISO Abbreviation: J Funct Biomater Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel : MDPI AG |
| مستخلص: | The current research focuses on the fabrication of water-soluble, reduced graphene oxide (rGO) employing thiourea (T) using a simple cost-effective method, and subsequently examining its anticancer characteristics. The cytotoxicity caused by graphene oxide (GO) and T-rGO is investigated in detail. Biological results reveal a concentration-dependent toxicity of GO and T-rGO in human colon cancer cells HT-29. A decrease in cell viability alongside DNA fragmentation is observed. Flow cytometry analysis confirms the cytotoxic effects. The novelty in this work is the use of raw graphite powder, and oxidants such as KMNO |
| References: | Int Rev Cytol. 1980;68:251-306. (PMID: 7014501) Nano Lett. 2007 Jul;7(7):1888-92. (PMID: 17592880) Int J Mol Sci. 2018 Mar 01;19(3):. (PMID: 29494563) Int J Nanomedicine. 2017 Aug 02;12:5501-5510. (PMID: 28814866) RSC Adv. 2022 Feb 16;12(9):5557-5570. (PMID: 35425568) Int J Mol Sci. 2021 Nov 22;22(22):. (PMID: 34830472) Colloids Surf B Biointerfaces. 2013 Nov 1;111:376-83. (PMID: 23850746) Biomaterials. 2011 Nov;32(33):8555-61. (PMID: 21839507) Nat Nanotechnol. 2009 Apr;4(4):217-24. (PMID: 19350030) Colloids Surf B Biointerfaces. 2022 Jun;214:112455. (PMID: 35305322) Molecules. 2016 Mar 18;21(3):375. (PMID: 26999102) Small. 2013 May 27;9(9-10):1492-503. (PMID: 22987582) ACS Omega. 2020 Mar 06;5(10):5041-5047. (PMID: 32201790) ACS Nano. 2010 Oct 26;4(10):5731-6. (PMID: 20925398) J Colloid Interface Sci. 2022 Feb 15;608(Pt 1):294-305. (PMID: 34626976) Int J Nanomedicine. 2013;8:2719-32. (PMID: 23940417) Adv Mater. 2010 Apr 18;22(15):1736-40. (PMID: 20496406) Bioengineering (Basel). 2022 Feb 23;9(3):. (PMID: 35324779) Adv Healthc Mater. 2013 Aug;2(8):1072-90. (PMID: 23526812) Nat Mater. 2007 Sep;6(9):652-5. (PMID: 17660825) Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10451-3. (PMID: 16027370) CA Cancer J Clin. 2012 Jan-Feb;62(1):10-29. (PMID: 22237781) Phys Rev Lett. 2006 Nov 3;97(18):187401. (PMID: 17155573) Nat Commun. 2011 Dec 06;2:571. (PMID: 22146390) CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29. (PMID: 25559415) Nat Nanotechnol. 2007 Oct;2(10):605-15. (PMID: 18654384) CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. (PMID: 21296855) ACS Omega. 2021 Jun 04;6(23):15147-15155. (PMID: 34151094) Biochimie. 2007 Dec;89(12):1544-52. (PMID: 17825975) Int J Nanomedicine. 2017 Sep 05;12:6537-6558. (PMID: 28919753) Chem Commun (Camb). 2011 Mar 21;47(11):3195-7. (PMID: 21286628) Int J Nanomedicine. 2021 Aug 30;16:5955-5980. (PMID: 34511900) Langmuir. 2010 Feb 16;26(4):2244-7. (PMID: 20099791) RSC Adv. 2022 Jan 18;12(4):2462-2472. (PMID: 35425250) World J Gastroenterol. 2009 Sep 28;15(36):4538-46. (PMID: 19777612) Int J Nanomedicine. 2014 Apr 08;9:1783-97. (PMID: 24741313) Science. 2008 Feb 29;319(5867):1229-32. (PMID: 18218865) Nature. 2006 Nov 16;444(7117):347-9. (PMID: 17108960) Int J Nanomedicine. 2015 Oct 05;10:6257-76. (PMID: 26491296) J Am Chem Soc. 2008 Jan 30;130(4):1362-6. (PMID: 18179214) Gastroenterol Clin North Am. 2002 Dec;31(4):925-43. (PMID: 12489270) Nanomaterials (Basel). 2022 Jun 06;12(11):. (PMID: 35683796) J Mater Chem B. 2013 Jan 28;1(4):493-499. (PMID: 32260820) Crit Rev Oncol Hematol. 2010 May;74(2):106-33. (PMID: 20138539) Nature. 1980 Apr 10;284(5756):555-6. (PMID: 6245367) Int J Nanomedicine. 2013;8:1015-27. (PMID: 23687445) Nat Mater. 2007 Mar;6(3):183-91. (PMID: 17330084) ACS Appl Mater Interfaces. 2011 Jul;3(7):2607-15. (PMID: 21650218) Sci Rep. 2022 Feb 4;12(1):1959. (PMID: 35121783) Materials (Basel). 2022 Jan 25;15(3):. (PMID: 35160865) Nature. 2006 Jul 20;442(7100):282-6. (PMID: 16855586) Int J Mol Sci. 2018 Dec 07;19(12):. (PMID: 30544611) Nat Commun. 2022 Jan 25;13(1):471. (PMID: 35079004) Int J Nanomedicine. 2013;8:413-20. (PMID: 23378763) Front Cell Dev Biol. 2021 Mar 18;9:616888. (PMID: 33816465) Int J Nanomedicine. 2012;7:5901-14. (PMID: 23226696) |
| فهرسة مساهمة: | Keywords: DNA fragmentation; colon cancer cells; flow cytometry analysis; reduced graphene oxide; scanning electron microscopy; thiourea |
| تواريخ الأحداث: | Date Created: 20220922 Latest Revision: 20220928 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9502518 |
| DOI: | 10.3390/jfb13030130 |
| PMID: | 36135565 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2079-4983 |
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| DOI: | 10.3390/jfb13030130 |