دورية أكاديمية
Chronic moderate hypercapnia suppresses ventilatory responses to acute CO<sub>2</sub> challenges.
| العنوان: | Chronic moderate hypercapnia suppresses ventilatory responses to acute CO<sub>2</sub> challenges. |
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| المؤلفون: | Buchholz KJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Neumueller SE; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Burgraff NJ; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, Washington., Hodges MR; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Pan L; Department of Physical Therapy, Marquette University, Milwaukee, Wisconsin., Forster HV; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin. |
| المصدر: | Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2022 Nov 01; Vol. 133 (5), pp. 1106-1118. Date of Electronic Publication: 2022 Sep 22. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1601 (Electronic) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD : American Physiological Society, c1985- |
| مواضيع طبية MeSH: | Hypercapnia* , Carbon Dioxide*, Animals ; Female ; Respiration ; Hypoxia ; Goats |
| مستخلص: | Chronic hypercapnia (CH) is a hallmark of chronic lung disease, and CH increases the risk for acute-on-chronic exacerbations leading to greater hypoxemia/hypercapnia and poor health outcomes. However, the role of hypercapnia per se (duration and severity) in determining an individual's ability to tolerate further hypercapnic exacerbations is unknown. Our primary objective herein was to test the hypothesis that mild-to-moderate CH (arterial [Formula: see text] ∼50-70 mmHg) increases susceptibility to pathophysiological responses to severe acute CO<sub>2</sub> challenges. Three groups (GR) of adult female goats were studied during 14 days of exposure to room air (<i>GR 1</i>; control) or 6% inspired CO<sub>2</sub> (<i>GR 2</i>; mild CH), or 7 days of 6% inspired CO<sub>2</sub> followed by 7 days of 8% inspired CO<sub>2</sub> (<i>GR 3</i>; moderate CH). Consistent with previous reports, there were no changes in physiological parameters in <i>GR 1</i> (RA control), but mild CH (<i>GR 2</i>) increased steady-state ventilation and transiently suppressed CO<sub>2</sub>/[H<sup>+</sup>] chemosensitivity. Further increasing InCO<sub>2</sub> from 6% to 8% (<i>GR 3</i>) transiently increased ventilation and arterial [H<sup>+</sup>]. Similar to mild CH, moderate CH increased ventilation to levels greater than predicted. However, in contrast to mild CH, acute ventilatory chemosensitivity was suppressed throughout the duration of moderate CH, and the arterial - mixed expired CO<sub>2</sub> gradient became negative. These data suggest that moderate CH limits physiological responses to acute severe exacerbations and provide evidence of recruitment of extrapulmonary systems (i.e., gastric CO<sub>2</sub> elimination) during times of moderate-severe hypercapnia.<b>NEW & NOTEWORTHY</b> Moderate levels of chronic hypercapnia (CH; ∼70 mmHg) in healthy adult female goats elicited similar steady-state physiological adaptations compared with mild CH (∼55 mmHg). However, unlike mild CH, moderate CH chronically suppressed acute CO<sub>2</sub>/[H<sup>+</sup>] chemosensitivity and reversed the arterial to mixed expired CO<sub>2</sub> gradient. These findings suggest that moderate CH suppresses vital mechanisms of ventilatory control and recruits additional physiological systems (i.e., gastric CO<sub>2</sub> release) to help buffer excess CO<sub>2</sub>. |
| References: | J Korean Med Sci. 2011 Sep;26(9):1209-13. (PMID: 21935278) J Appl Physiol (1985). 2010 May;108(5):1417-24. (PMID: 20133433) Chest. 2019 Aug;156(2):228-238. (PMID: 31154041) J Appl Physiol. 1963 Nov;18:1079-84. (PMID: 14080723) Chest. 2000 Jan;117(1):169-77. (PMID: 10631216) Chest. 2012 Nov;142(5):1193-1199. (PMID: 22677348) J Appl Physiol (1985). 2009 Apr;106(4):1464-6. (PMID: 18467549) Pathophysiology. 2004 Jul;11(1):23-30. (PMID: 15177512) Intensive Care Med. 2017 Feb;43(2):200-208. (PMID: 28108768) Transl Res. 2013 Oct;162(4):208-18. (PMID: 23684710) Int J Chron Obstruct Pulmon Dis. 2016 Feb 03;11:207-16. (PMID: 26893552) Am J Respir Crit Care Med. 2011 Aug 15;184(4):414-20. (PMID: 21562134) J Appl Physiol Respir Environ Exerc Physiol. 1979 Nov;47(5):1074-8. (PMID: 511709) Vet Clin North Am Small Anim Pract. 2002 Sep;32(5):1049-58. (PMID: 12380164) Lancet. 2007 Sep 1;370(9589):786-96. (PMID: 17765528) Annu Rev Physiol. 1971;33:131-54. (PMID: 4951048) Respir Physiol Neurobiol. 2015 Sep 15;216:86-93. (PMID: 25891787) N Engl J Med. 2010 Sep 16;363(12):1128-38. (PMID: 20843247) Am J Respir Crit Care Med. 1999 Jan;159(1):158-64. (PMID: 9872834) Chest. 2003 Aug;124(2):459-67. (PMID: 12907529) Respir Physiol. 2001 Dec;129(1-2):25-35. (PMID: 11738644) Behav Processes. 2008 Nov;79(3):156-64. (PMID: 18694810) COPD. 2017 Feb;14(1):72-79. (PMID: 27419254) Undersea Biomed Res. 1979;6 Suppl:S91-114. (PMID: 505632) Mayo Clin Proc. 2017 Jul;92(7):1104-1112. (PMID: 28688465) J Appl Physiol. 1971 Sep;31(3):490-6. (PMID: 5111869) Front Neurosci. 2019 Dec 13;13:1343. (PMID: 31920508) J Physiol. 2017 Apr 15;595(8):2431-2437. (PMID: 28044311) Respir Physiol Neurobiol. 2011 Feb 15;175(2):189-209. (PMID: 21144912) Am J Respir Crit Care Med. 2007 Sep 15;176(6):532-55. (PMID: 17507545) J Appl Physiol (1985). 1998 Jun;84(6):2099-105. (PMID: 9609805) BMC Pulm Med. 2018 Jan 25;18(1):18. (PMID: 29370849) Paediatr Respir Rev. 2010 Mar;11(1):3-8. (PMID: 20113985) Proc Am Thorac Soc. 2008 May 1;5(4):530-5. (PMID: 18453367) Physiol Behav. 1979 Sep;23(3):455-9. (PMID: 504436) Eur Respir J. 1995 Jan;8(1):78-85. (PMID: 7744198) Respir Physiol. 1969 Aug;7(2):173-87. (PMID: 5823831) J Appl Physiol (1985). 2021 Apr 1;130(4):1259-1273. (PMID: 33539265) Chest. 2005 Oct;128(4):2012-6. (PMID: 16236849) J Appl Physiol (1985). 1985 Oct;59(4):1214-21. (PMID: 4055600) J Appl Physiol. 1976 Dec;41(6):839-47. (PMID: 12131) COPD. 2012 Apr;9(2):131-41. (PMID: 22409371) Respir Physiol. 1973 Mar;17(2):178-94. (PMID: 4689454) Int J Mol Sci. 2020 Jan 31;21(3):. (PMID: 32023946) Int J Chron Obstruct Pulmon Dis. 2011;6:199-208. (PMID: 21660297) Respiration. 2013;85(1):15-26. (PMID: 23037178) J Appl Physiol. 1975 Mar;38(3):382-8. (PMID: 238927) Int J Chron Obstruct Pulmon Dis. 2015 Apr 24;10:823-30. (PMID: 25977604) Experientia. 1982 Oct 15;38(10):1163-8. (PMID: 6814945) J Appl Physiol. 1963 Nov;18:1071-8. (PMID: 14080722) Neth J Med. 2000 Jun;56(6):215-22. (PMID: 10821977) Int J Chron Obstruct Pulmon Dis. 2020 Sep 24;15:2249-2256. (PMID: 33061342) Open Access Emerg Med. 2020 Jun 26;12:173-180. (PMID: 32617025) J Physiol. 2018 Nov;596(22):5343-5363. (PMID: 30211447) J Clin Lab Anal. 2021 Apr;35(4):e23733. (PMID: 33764623) Muscle Nerve. 2004 Jan;29(1):5-27. (PMID: 14694494) Proc Am Thorac Soc. 2008 Feb 15;5(2):218-25. (PMID: 18250215) Bull Eur Physiopathol Respir. 1976 Jan-Feb;12(1):19-32. (PMID: 1016773) J Comp Psychol. 2006 Feb;120(1):58-66. (PMID: 16551165) Chest. 2001 Feb;119(2):565-71. (PMID: 11171739) Wien Klin Wochenschr. 2018 Oct;130(19-20):561-568. (PMID: 30066095) |
| معلومات مُعتمدة: | F31 HL159908 United States HL NHLBI NIH HHS; I01 BX003284 United States BX BLRD VA; BX003284 U.S. Department of Veterans Affairs (VA) |
| فهرسة مساهمة: | Keywords: acute chemosensitivity; control of breathing; hypercapnia |
| سلسلة جزيئية: | figshare 10.6084/m9.figshare.20263800.v1 |
| المشرفين على المادة: | 142M471B3J (Carbon Dioxide) |
| تواريخ الأحداث: | Date Created: 20220922 Date Completed: 20221101 Latest Revision: 20231102 |
| رمز التحديث: | 20231102 |
| مُعرف محوري في PubMed: | PMC9621709 |
| DOI: | 10.1152/japplphysiol.00407.2022 |
| PMID: | 36135953 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1601 |
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| DOI: | 10.1152/japplphysiol.00407.2022 |