دورية أكاديمية
أعرض في EDS

microRNAs Control Antiviral Immune Response, Cell Death and Chemotaxis Pathways in Human Neuronal Precursor Cells (NPCs) during Zika Virus Infection.

التفاصيل البيبلوغرافية
العنوان: microRNAs Control Antiviral Immune Response, Cell Death and Chemotaxis Pathways in Human Neuronal Precursor Cells (NPCs) during Zika Virus Infection.
المؤلفون: Polonio CM; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-000, Brazil., da Silva P; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-000, Brazil., Russo FB; Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-000, Brazil.; Disease Modeling Laboratory at Department of Microbiology, Institute of Biomedical Sciences, São Paulo 05508-000, Brazil., Hyppolito BRN; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Immunopathology and Allergy Post Graduate Program, School of Medicine, University of São Paulo, São Paulo 05508-000, Brazil., Zanluqui NG; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-000, Brazil.; Immunopathology and Allergy Post Graduate Program, School of Medicine, University of São Paulo, São Paulo 05508-000, Brazil., Benazzato C; Disease Modeling Laboratory at Department of Microbiology, Institute of Biomedical Sciences, São Paulo 05508-000, Brazil., Beltrão-Braga PCB; Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-000, Brazil.; Disease Modeling Laboratory at Department of Microbiology, Institute of Biomedical Sciences, São Paulo 05508-000, Brazil., Muxel SM; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-000, Brazil., Peron JPS; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-000, Brazil.; Immunopathology and Allergy Post Graduate Program, School of Medicine, University of São Paulo, São Paulo 05508-000, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 07; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: MicroRNAs*/genetics , Microcephaly*/genetics , Nervous System Malformations* , Zika Virus*/physiology , Zika Virus Infection*, Animals ; Antiviral Agents ; Cell Death/genetics ; Chemotaxis ; Female ; Humans ; Immunity ; Mosquito Vectors ; Pregnancy
مستخلص: Viral infections have always been a serious burden to public health, increasing morbidity and mortality rates worldwide. Zika virus (ZIKV) is a flavivirus transmitted by the Aedes aegypti vector and the causative agent of severe fetal neuropathogenesis and microcephaly. The virus crosses the placenta and reaches the fetal brain, mainly causing the death of neuronal precursor cells (NPCs), glial inflammation, and subsequent tissue damage. Genetic differences, mainly related to the antiviral immune response and cell death pathways greatly influence the susceptibility to infection. These components are modulated by many factors, including microRNAs (miRNAs). MiRNAs are small noncoding RNAs that regulate post-transcriptionally the overall gene expression, including genes for the neurodevelopment and the formation of neural circuits. In this context, we investigated the pathways and target genes of miRNAs modulated in NPCs infected with ZIKV. We observed downregulation of miR-302b, miR-302c and miR-194, whereas miR-30c was upregulated in ZIKV infected human NPCs in vitro. The analysis of a public dataset of ZIKV-infected human NPCs evidenced 262 upregulated and 3 downregulated genes, of which 142 were the target of the aforementioned miRNAs. Further, we confirmed a correlation between miRNA and target genes affecting pathways related to antiviral immune response, cell death and immune cells chemotaxis, all of which could contribute to the establishment of microcephaly and brain lesions. Here, we suggest that miRNAs target gene expression in infected NPCs, directly contributing to the pathogenesis of fetal microcephaly.
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معلومات مُعتمدة: #2017/26170-0 FAPESP; #2017/22504-1 FAPESP; #2020/06145-4 FAPESP; #330301 G4-Associated Researcher of Pasteur Institute; #2022/00291-4 FAPESP; #2017/11828-0 FAPESP; #2019/13731-0. FAPESP; #2021/01717-2 FAPESP; #88887.599914/2021-00 CAPESP GRANT; #2016/07371-2 FAPESP; #2018/16748-8 FAPESP
فهرسة مساهمة: Keywords: ZIKV; cell death; chemotaxis; inflammation; microRNA
المشرفين على المادة: 0 (Antiviral Agents)
0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20220923 Date Completed: 20220926 Latest Revision: 20220928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9499039
DOI: 10.3390/ijms231810282
PMID: 36142200
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms231810282