دورية أكاديمية
أعرض في EDS

Potential Cardioprotective Effects and Lipid Mediator Differences in Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplemented Mice Given Chemotherapy.

التفاصيل البيبلوغرافية
العنوان: Potential Cardioprotective Effects and Lipid Mediator Differences in Long-Chain Omega-3 Polyunsaturated Fatty Acid Supplemented Mice Given Chemotherapy.
المؤلفون: Angelotti A; Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA., Snoke DB; Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.; Department of Medicine, University of Vermont Larner College of Medicine, Burlington, VT 05405, USA., Ormiston K; Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA., Cole RM; Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA., Borkowski K; West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA 95616, USA., Newman JW; West Coast Metabolomics Center, Genome Center, University of California Davis, Davis, CA 95616, USA.; Western Human Nutrition Research Center, United States Department of Agriculture-Agriculture Research Service, Davis, CA 95616, USA.; Department of Nutrition, University of California-Davis, Davis, CA 95616, USA., Orchard TS; Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA., Belury MA; Department of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
المصدر: Metabolites [Metabolites] 2022 Aug 24; Vol. 12 (9). Date of Electronic Publication: 2022 Aug 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Many commonly used chemotherapies induce mitochondrial dysfunction in cardiac muscle, which leads to cardiotoxicity and heart failure later in life. Dietary long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) have demonstrated cardioprotective function in non-chemotherapy models of heart failure, potentially through the formation of LC n-3 PUFA-derived bioactive lipid metabolites. However, it is unknown whether dietary supplementation with LC n-3 PUFA can protect against chemotherapy-induced cardiotoxicity. To test this, 36 female ovariectomized C57BL/6J mice were randomized in a two-by-two factorial design to either a low (0 g/kg EPA + DHA) or high (12.2 g/kg EPA + DHA) LC n-3 PUFA diet, and received either two vehicle or two chemotherapy (9 mg/kg anthracycline + 90 mg/kg cyclophosphamide) tail vein injections separated by two weeks. Body weight and food intake were measured as well as heart gene expression and fatty acid composition. Heart mitochondria were isolated using differential centrifugation. Mitochondrial isolate oxylipin and N-acylethanolamide levels were measured by mass spectrometry after alkaline hydrolysis. LC n-3 PUFA supplementation attenuated some chemotherapy-induced differences ( Myh7 , Col3a1 ) in heart gene expression, and significantly altered various lipid species in cardiac mitochondrial preparations including several epoxy fatty acids [17(18)-EpETE] and N-acylethanolamines (arachidonoylethanolamine, AEA), suggesting a possible functional link between heart lipids and cardiotoxicity.
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معلومات مُعتمدة: R01 CA189947 United States CA NCI NIH HHS; R01CA189947 United States CA NCI NIH HHS; 20325153002500D United States Department of Agriculture
فهرسة مساهمة: Keywords: chemotherapy; diet; endocannabinoids; heart; lipid mediators; mitochondria; omega-3 fatty acids; oxylipins
تواريخ الأحداث: Date Created: 20220923 Latest Revision: 20220928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9505633
DOI: 10.3390/metabo12090782
PMID: 36144189
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo12090782