دورية أكاديمية
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The Wound-Healing Potential of Olea europaea L. Cv. Arbequina Leaves Extract: An Integrated In Vitro, In Silico, and In Vivo Investigation.

التفاصيل البيبلوغرافية
العنوان: The Wound-Healing Potential of Olea europaea L. Cv. Arbequina Leaves Extract: An Integrated In Vitro, In Silico, and In Vivo Investigation.
المؤلفون: Al-Warhi T; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Elmaidomy AH; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, Egypt., Maher SA; Department of Biochemistry, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt., Abu-Baih DH; Department of Biochemistry, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt., Selim S; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 72341, Saudi Arabia., Albqmi M; Chemistry Department, College of Science and Arts, Jouf University, Alqurayyat 77447, Saudi Arabia., Al-Sanea MM; Pharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Alnusaire TS; Biology Department, College of Science, Jouf University, Sakaka 72341, Saudi Arabia., Ghoneim MM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.; Department of Pharmacy Practice, College of Pharmacy, Al Maarefa University, Ad Diriyah 13713, Saudi Arabia., Mostafa EM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.; Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., Hussein S; Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia., El-Damasy AK; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea., Saber EA; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia 61519, Egypt.; Department of Histology and Cell Biology, Deraya University, Universities Zone, New Minia 61111, Egypt., Elrehany MA; Department of Biochemistry, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt., Sayed AM; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt., Othman EM; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.; Department of Bioinformatics, Biocenter, University of Würzburg, Am Hubland, 97074 Wuerzburg, Germany., El-Sherbiny M; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, Riyadh 11597, Saudi Arabia.; Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, New Minia 61111, Egypt.
المصدر: Metabolites [Metabolites] 2022 Aug 25; Vol. 12 (9). Date of Electronic Publication: 2022 Aug 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Olea europaea L. Cv. Arbequina (OEA) (Oleaceae) is an olive variety species that has received little attention. Besides our previous work for the chemical profiling of OEA leaves using LC−HRESIMS, an additional 23 compounds are identified. An excision wound model is used to measure wound healing action. Wounds are provided with OEA (2% w/v) or MEBO® cream (marketed treatment). The wound closure rate related to vehicle-treated wounds is significantly increased by OEA. Comparing to vehicle wound tissues, significant levels of TGF-β in OEA and MEBO® (p < 0.05) are displayed by gene expression patterns, with the most significant levels in OEA-treated wounds. Proinflammatory TNF-α and IL-1β levels are substantially reduced in OEA-treated wounds. The capability of several lignan-related compounds to interact with MMP-1 is revealed by extensive in silico investigation of the major OEA compounds (i.e., inverse docking, molecular dynamics simulation, and ΔG calculation), and their role in the wound-healing process is also characterized. The potential of OEA as a potent MMP-1 inhibitor is shown in subsequent in vitro testing (IC50 = 88.0 ± 0.1 nM). In conclusion, OEA is introduced as an interesting therapeutic candidate that can effectively manage wound healing because of its anti-inflammatory and antioxidant properties.
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فهرسة مساهمة: Keywords: LC–HRESIMS; MMP-1; Olea; TGF-β; TNF-α; olive; virtual docking; wound
تواريخ الأحداث: Date Created: 20220923 Latest Revision: 20230308
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9503157
DOI: 10.3390/metabo12090791
PMID: 36144197
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo12090791