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Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells.
المؤلفون: Kim SH; Department of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.; Department of Integrated Biomedical and Life Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea., Song JH; Department of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.; Department of Integrated Biomedical and Life Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea., Kim MJ; Department of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.; Department of Integrated Biomedical and Life Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea., Song MG; Department of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.; Department of Integrated Biomedical and Life Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea., Ku AA; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA.; Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA., Bandyopadhyay S; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA.; Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA., McCormick F; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA.; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA., Kim SE; Department of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.; Department of Integrated Biomedical and Life Sciences, College of Health Sciences, Korea University, Seoul 02841, Korea.
المصدر: Metabolites [Metabolites] 2022 Sep 02; Vol. 12 (9). Date of Electronic Publication: 2022 Sep 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Cancer cells utilize multiple nutrient scavenging mechanisms to support growth and survival in nutrient-poor, hypoxic tumor microenvironments. Among these mechanisms, macropinocytosis has emerged as an important pathway of extracellular nutrient acquisition in cancer cells, particularly in tumors with activated RAS signaling, such as pancreatic cancer. However, the absence of a clinically available inhibitor, as well as the gap of knowledge in macropinocytosis regulation, remain a hurdle for its use for cancer therapy. Here, we use the Informer set library to identify novel regulators of macropinocytosis-dependent growth in pancreatic cancer cells. Understanding how these regulators function will allow us to provide novel opportunities for therapeutic intervention.
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معلومات مُعتمدة: T32 GM007175 United States GM NIGMS NIH HHS; 2020R1C1C1013220 National Research Foundation of Korea
فهرسة مساهمة: Keywords: Informer set library screening; cancer metabolism; macropinocytosis; nutrient scavenging; pancreatic cancer
تواريخ الأحداث: Date Created: 20220923 Latest Revision: 20221009
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9502772
DOI: 10.3390/metabo12090831
PMID: 36144235
قاعدة البيانات: MEDLINE
الوصف
تدمد:2218-1989
DOI:10.3390/metabo12090831