دورية أكاديمية
أعرض في EDS

Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor.

التفاصيل البيبلوغرافية
العنوان: Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor.
المؤلفون: Emert-Sedlak LA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Shi H; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Tice CM; Fox Chase Chemical Diversity Center, Inc., Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA., Chen L; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Alvarado JJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Shu ST; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Du S; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Thomas CE; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA., Wrobel JE; Fox Chase Chemical Diversity Center, Inc., Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA., Reitz AB; Fox Chase Chemical Diversity Center, Inc., Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA., Smithgall TE; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.
المصدر: Viruses [Viruses] 2022 Sep 13; Vol. 14 (9). Date of Electronic Publication: 2022 Sep 13.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: HIV Infections*/drug therapy , HIV Seropositivity* , HIV-1*/physiology, Anti-Retroviral Agents/therapeutic use ; Drug Discovery ; Humans ; Virulence Factors ; nef Gene Products, Human Immunodeficiency Virus
مستخلص: While antiretroviral drugs have transformed the lives of HIV-infected individuals, chronic treatment is required to prevent rebound from viral reservoir cells. People living with HIV also are at higher risk for cardiovascular and neurocognitive complications, as well as cancer. Finding a cure for HIV-1 infection is therefore an essential goal of current AIDS research. This review is focused on the discovery of pharmacological inhibitors of the HIV-1 Nef accessory protein. Nef is well known to enhance HIV-1 infectivity and replication, and to promote immune escape of HIV-infected cells by preventing cell surface MHC-I display of HIV-1 antigens. Recent progress shows that Nef inhibitors not only suppress HIV-1 replication, but also restore sufficient MHC-I to the surface of infected cells to trigger a cytotoxic T lymphocyte response. Combining Nef inhibitors with latency reversal agents and therapeutic vaccines may provide a path to clearance of viral reservoirs.
References: J Biol Chem. 2005 Apr 1;280(13):12840-8. (PMID: 15653685)
Traffic. 2016 Sep;17(9):976-96. (PMID: 27161574)
Nat Struct Mol Biol. 2020 Sep;27(9):822-828. (PMID: 32719457)
Cell Mol Life Sci. 2008 Oct;65(19):3058-73. (PMID: 18563293)
J Exp Med. 2003 Aug 4;198(3):443-53. (PMID: 12900520)
Retrovirology. 2013 Nov 14;10:135. (PMID: 24229420)
J Immunol Methods. 2015 Nov;426:104-13. (PMID: 26319395)
Cell. 1991 May 17;65(4):651-62. (PMID: 2032289)
J Virol. 2019 Mar 5;93(6):. (PMID: 30602611)
Biophys J. 2010 Sep 22;99(6):1940-8. (PMID: 20858440)
Chem Biol. 2013 Jan 24;20(1):82-91. (PMID: 23352142)
ACS Infect Dis. 2022 Jan 14;8(1):91-105. (PMID: 34985256)
Nature. 2015 Oct 8;526(7572):212-7. (PMID: 26416734)
Oncogene. 2002 Mar 27;21(13):2037-50. (PMID: 11960376)
Nat Chem Biol. 2010 Jan;6(1):46-53. (PMID: 19935658)
Bioorg Med Chem. 2011 Dec 15;19(24):7401-6. (PMID: 22061824)
Structure. 2013 Oct 8;21(10):1822-33. (PMID: 24035710)
Infect Dis Clin North Am. 2019 Sep;33(3):787-805. (PMID: 31395145)
Science. 1995 Nov 10;270(5238):988-91. (PMID: 7481804)
Oncogene. 2004 Oct 18;23(48):7918-27. (PMID: 15489910)
Nature. 2020 Feb;578(7793):154-159. (PMID: 31969705)
J Biol Chem. 2020 Oct 30;295(44):15158-15171. (PMID: 32862141)
N Engl J Med. 1995 Jan 26;332(4):228-32. (PMID: 7808489)
PLoS One. 2012;7(2):e32561. (PMID: 22393415)
J Biol Chem. 2014 Oct 10;289(41):28539-53. (PMID: 25122770)
J Biol Chem. 1997 Jul 18;272(29):17899-902. (PMID: 9218412)
Retrovirology. 2012 May 28;9:44. (PMID: 22640559)
J Biomol Screen. 2014 Apr;19(4):556-65. (PMID: 24282155)
EMBO Rep. 2001 Jul;2(7):580-5. (PMID: 11463741)
Nat Struct Biol. 2002 May;9(5):365-9. (PMID: 11976726)
Curr HIV Res. 2011 Oct;9(7):490-5. (PMID: 22103832)
Mol Cell. 1999 Jun;3(6):729-39. (PMID: 10394361)
Virologie (Montrouge). 2022 Jan 1;26(1):17-33. (PMID: 35766095)
J Biol Chem. 2008 Apr 25;283(17):11772-84. (PMID: 18296443)
Nature. 2015 Oct 8;526(7572):218-23. (PMID: 26416733)
J Biol Chem. 2006 Sep 15;281(37):27029-38. (PMID: 16849330)
PLoS One. 2011;6(11):e27696. (PMID: 22110726)
JCI Insight. 2017 Sep 7;2(17):. (PMID: 28878119)
Chem Biol. 2003 May;10(5):443-51. (PMID: 12770826)
N Engl J Med. 2009 Dec 3;361(23):2209-20. (PMID: 19843557)
Biochemistry. 2015 Oct 20;54(41):6382-91. (PMID: 26440750)
Nature. 2020 Feb;578(7793):160-165. (PMID: 31969707)
J Clin Invest. 2022 Apr 1;132(7):. (PMID: 35133986)
Front Immunol. 2019 Sep 10;10:2151. (PMID: 31572371)
Cell Host Microbe. 2007 Apr 19;1(2):121-33. (PMID: 18005690)
ACS Infect Dis. 2020 Feb 14;6(2):302-312. (PMID: 31775511)
J Infect. 2012 Dec;65(6):549-58. (PMID: 23085245)
PLoS Pathog. 2021 Nov 15;17(11):e1009728. (PMID: 34780577)
Biochim Biophys Acta. 2015 Apr;1850(4):733-41. (PMID: 25585010)
Retrovirology. 2015 Jul 14;12:61. (PMID: 26169178)
J Mol Biol. 1999 May 28;289(1):123-38. (PMID: 10339411)
J Mol Biol. 2018 Feb 2;430(3):310-321. (PMID: 29258818)
Cell. 1996 Jun 14;85(6):931-42. (PMID: 8681387)
Curr HIV Res. 2011 Oct;9(7):531-42. (PMID: 22103837)
EMBO J. 1995 Feb 1;14(3):484-91. (PMID: 7859737)
Nature. 1997 Feb 13;385(6617):650-3. (PMID: 9024665)
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23835-23846. (PMID: 32900948)
Mol Biol Cell. 2010 Oct 1;21(19):3279-92. (PMID: 20702582)
ACS Chem Biol. 2009 Nov 20;4(11):939-47. (PMID: 19807124)
Nat Struct Mol Biol. 2012 Jun 17;19(7):701-6. (PMID: 22705789)
Bioorg Med Chem Lett. 2016 Mar 1;26(5):1480-1484. (PMID: 26852364)
J Virol. 2013 Apr;87(7):3729-40. (PMID: 23325686)
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19256-61. (PMID: 18042718)
Annu Rev Biophys. 2019 May 6;48:19-44. (PMID: 30786230)
Cell Host Microbe. 2018 Jan 10;23(1):14-26. (PMID: 29324227)
Eur J Cell Biol. 2008 Sep;87(8-9):527-42. (PMID: 18538446)
معلومات مُعتمدة: R56 AI102724 United States AI NIAID NIH HHS; R01 AI102724 United States AI NIAID NIH HHS; GM112516 United States GM NIGMS NIH HHS; R01 AI057083 United States AI NIAID NIH HHS; R41 GM112516 United States GM NIGMS NIH HHS; AI152677, AI057083, AI102724 United States AI NIAID NIH HHS; R42 GM112516 United States GM NIGMS NIH HHS; R01 AI152677 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: AIDS; HIV-1; MHC-I; Nef; Nef inhibitor; antiretroviral; latent viral reservoir
المشرفين على المادة: 0 (Anti-Retroviral Agents)
0 (Virulence Factors)
0 (nef Gene Products, Human Immunodeficiency Virus)
0 (nef protein, Human immunodeficiency virus 1)
0 (nef protein, Human immunodeficiency virus 2)
تواريخ الأحداث: Date Created: 20220923 Date Completed: 20220926 Latest Revision: 20221005
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9503669
DOI: 10.3390/v14092025
PMID: 36146831
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v14092025