دورية أكاديمية
Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection.
| العنوان: | Folic acid-functionalized graphene quantum dots: Synthesis, characterization, radiolabeling with radium-223 and antiviral effect against Zika virus infection. |
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| المؤلفون: | Pijeira MSO; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil., de Menezes AS; Federal University of Maranhão, Department of Physics, Maranhão 65080805, Brazil., Fechine PBA; Group of Chemistry of Advanced Materials (GQMat) - Department of Analytical Chemistry and Physical Chemistry, Science Center, Federal University of Ceará (UFC), Fortaleza 60455-760, Brazil., Shah SQ; Biochemistry and Nuclear Medicine Research Laboratory, Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120 K.P, Pakistan., Ilem-Ozdemir D; Ege University, Faculty of Pharmacy, Department of Radiopharmacy, Bornova, Izmir 35040, Turkey., López EO; Department of Experimetal Low Energy Physics, Brazilian Center for Research in Physics (CBPF), Rio de Janeiro 22290180, Brazil., Maricato JT; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo 04021001, Brazil., Rosa DS; Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo 04021001, Brazil., Ricci-Junior E; Laboratório de Desenvolvimento Galênico, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil., Junior SA; Laboratório de Terras Raras, Departamento de Química, Centro de Ciências Exatas e da Natureza (CCEN), Universidade Federal de Pernambuco, Recife 50740-560, Brazil., Alencar LMR; Federal University of Maranhão, Department of Physics, Maranhão 65080805, Brazil., Santos-Oliveira R; Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro 21941906, Brazil; Rio de Janeiro State University, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro 23070200, Brazil. Electronic address: roliveira@ien.gov.br. |
| المصدر: | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2022 Nov; Vol. 180, pp. 91-100. Date of Electronic Publication: 2022 Sep 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science Original Publication: Stuttgart : Wissenschaftliche Verlagsgesellschaft, c1991- |
| مواضيع طبية MeSH: | Quantum Dots*/chemistry , Graphite*/chemistry , Zika Virus Infection* , Zika Virus*, Humans ; Folic Acid/chemistry ; Antiviral Agents/pharmacology |
| مستخلص: | The use of graphene quantum dots as biomedical devices and drug delivery systems has been increasing. The nano-platform of pure carbon has shown unique properties and is approved to be safe for human use. In this study, we successfully produced and characterized folic acid-functionalized graphene quantum dots (GQD-FA) to evaluate their antiviral activity against Zika virus (ZIKV) infection in vitro, and for radiolabeling with the alpha-particle emitting radionuclide radium-223. The in vitro results exhibited the low cytotoxicity of the nanoprobe GQD-FA in Vero E6 cells and the antiviral effect against replication of the ZIKV infection. In addition, our findings demonstrated that functionalization with folic acid doesn't improve the antiviral effect of graphene quantum dots against ZIVK replication in vitro. On the other hand, the radiolabeled nanoprobe 223 Ra@GQD-FA was also produced as confirmed by the Energy Dispersive X-Ray Spectroscopy analysis. 223 Ra@GQD-FA might expand the application of alpha targeted therapy using radium-223 in folate receptor-overexpressing tumors. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomedical device; Drug delivery; Folic acid; GQD-FA; Graphene quantum dots; Nanoparticle; Radium-223; Smart material; Targeted alpha therapy; Zika virus infection |
| المشرفين على المادة: | 7782-42-5 (Graphite) 935E97BOY8 (Folic Acid) 8BR2SOL3L1 (Radium-223) 0 (Antiviral Agents) |
| تواريخ الأحداث: | Date Created: 20220926 Date Completed: 20221115 Latest Revision: 20221115 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ejpb.2022.09.019 |
| PMID: | 36154904 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3441 |
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| DOI: | 10.1016/j.ejpb.2022.09.019 |