دورية أكاديمية
أعرض في EDS

Novel Ru(II)-bipyridine/phenanthroline-lapachol complexes as potential anti-cancer agents.

التفاصيل البيبلوغرافية
العنوان: Novel Ru(II)-bipyridine/phenanthroline-lapachol complexes as potential anti-cancer agents.
المؤلفون: De Grandis RA; UNIARA - University of Araraquara, Department of Biological Sciences and Health, Araraquara, São Paulo, Brazil; UFSCar - Federal University of São Carlos, Department of Chemistry, São Carlos, São Paulo, Brazil. Electronic address: radgrandis@uniara.edu.br., Costa AR; UFSCar - Federal University of São Carlos, Department of Chemistry, São Carlos, São Paulo, Brazil., Moraes CAF; UFSCar - Federal University of São Carlos, Department of Chemistry, São Carlos, São Paulo, Brazil., Sampaio NZ; UNIARA - University of Araraquara, Department of Biological Sciences and Health, Araraquara, São Paulo, Brazil., Cerqueira IH; UNIARA - University of Araraquara, Department of Biological Sciences and Health, Araraquara, São Paulo, Brazil., Marques WG; UNIARA - University of Araraquara, Department of Biological Sciences and Health, Araraquara, São Paulo, Brazil., Guedes APM; UFSCar - Federal University of São Carlos, Department of Chemistry, São Carlos, São Paulo, Brazil., de Araujo-Neto JH; UFSCar - Federal University of São Carlos, Department of Chemistry, São Carlos, São Paulo, Brazil., Pavan FR; UNESP - São Paulo State University, Department of Biological Sciences, School of Pharmaceutical Sciences, Araraquara, São Paulo, Brazil., Demidoff FC; UFRJ - Federal University of Rio de Janeiro, Institute of Chemistry, Macaé, Rio de Janeiro, Brazil., Netto CD; UFRJ - Federal University of Rio de Janeiro, Institute of Chemistry, Macaé, Rio de Janeiro, Brazil., Batista AA; UFSCar - Federal University of São Carlos, Department of Chemistry, São Carlos, São Paulo, Brazil. Electronic address: daab@ufscar.br., Resende FA; UNIARA - University of Araraquara, Department of Biological Sciences and Health, Araraquara, São Paulo, Brazil. Electronic address: farnogueira@uniara.edu.br.
المصدر: Journal of inorganic biochemistry [J Inorg Biochem] 2022 Dec; Vol. 237, pp. 112005. Date of Electronic Publication: 2022 Sep 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, Elsevier.
مواضيع طبية MeSH: Coordination Complexes*/pharmacology , Coordination Complexes*/chemistry , Ruthenium*/chemistry , Antineoplastic Agents*/chemistry , Adenocarcinoma* , Carcinoma*, Male ; Humans ; Phenanthrolines ; Reactive Oxygen Species/metabolism ; Ligands ; Caco-2 Cells ; Cell Line, Tumor
مستخلص: For the first time, we herein report on the syntheses of two new Ru(II)/bipyridine/phenanthroline complexes containing lapachol as ligand: complex (1), [Ru (bipy) 2 (Lap)]PF 6 and complex (2), [Ru(Lap)(phen) 2 ]PF 6 , where bipy = 2,2'-bipyridine and ph en = 1,10-phenanthroline; Lap = lapachol (2-hydroxy-3-(3-methylbut-2-en-1- yl)naphthalene-1,4-dione). The complexes were synthesized and characterized by elemental analyses, molar conductivity, mass spectrometry, ultraviolet-visible and infrared spectroscopies, nuclear magnetic resonance ( 1 H, 13 C), and single crystal X-ray diffraction, for complex (2). In addition, in vitro cytotoxicity was tested against six cancer cells: A549 (lung carcinoma); DU-145 (human prostate carcinoma); HepG2 (human hepatocellular carcinoma), PC-3 (human prostate adenocarcinoma); MDA-MB-231 (human breast adenocarcinoma); Caco-2 (human colorectal adenocarcinoma), and against two non-cancer cells, FGH (human gingival normal fibroblasts) and PNT-2 (prostate epithelial cells). Complex (1) was slightly more toxic and selective than complex (2) for all cell lines, except against the A549 cells, where (2) was more potent than complex (1). The complexes induced an increase in the reactive oxygen species, and the co-treatment with N-acetyl-L-cysteine remarkably suppressed the ROS generation and prevented the reduction of cell viability, suggesting that the cytotoxicity of the complexes is related to the ROS-mediated pathway. Further studies indicated that the complexes may bind to DNA via minor groove interaction. Our studies also revealed that free Lap induces gene mutations in Salmonella Typhimurium, nevertheless, the complexes demonstrated the absence of genotoxicity by the Ames test. The present study provides a relevant contribution to understanding the anti-cancer potential and genetic toxicological events of new ruthenium complexes containing the lapachol molecule as a ligand.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Cytotoxicity; Genotoxicity; Lapachol; Reactive oxygen species; Ruthenium complexes
المشرفين على المادة: 0 (Phenanthrolines)
B221938VB6 (lapachol)
0 (Coordination Complexes)
0 (Reactive Oxygen Species)
0 (Ligands)
7UI0TKC3U5 (Ruthenium)
0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20220926 Date Completed: 20221101 Latest Revision: 20230117
رمز التحديث: 20240628
DOI: 10.1016/j.jinorgbio.2022.112005
PMID: 36155170
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3344
DOI:10.1016/j.jinorgbio.2022.112005