دورية أكاديمية
Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China.
| العنوان: | Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China. |
|---|---|
| المؤلفون: | Liao MJ; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China., Li J; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China.; Genetics and Precision Medicine Laboratory, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Dang W; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Chen DB; Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Beijing 100044, China., Qin WY; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Chen P; Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Beijing 100044, China., Zhao BG; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Ren LY; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Xu TF; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Chen HS; Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Beijing 100044, China., Liao WJ; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China. liaoweijia288@163.com. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2022 Jul 21; Vol. 28 (27), pp. 3503-3513. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Hepatitis B, Chronic*/complications , Hepatitis B, Chronic*/diagnosis , Hepatitis B, Chronic*/pathology, Alkaline Phosphatase ; Aspartate Aminotransferases ; Biomarkers ; China/epidemiology ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology ; Platelet Count ; ROC Curve ; Retrospective Studies ; gamma-Glutamyltransferase |
| مستخلص: | Background: Noninvasive, practical, and convenient means of detection for the prediction of liver fibrosis and cirrhosis in China are greatly needed. Aim: To develop a precise noninvasive test to stage liver fibrosis and cirrhosis. Methods: With liver biopsy as the gold standard, we established a new index, [alkaline phosphatase (U/L) + gamma-glutamyl transpeptidase (U/L)/platelet (10 9 /L) (AGPR)], to predict liver fibrosis and cirrhosis. In addition, we compared the area under the receiver operating characteristic curve (AUROC) of AGPR, gamma-glutamyl transpeptidase to platelet ratio, aspartate transaminase to platelet ratio index, and FIB-4 and evaluated the accuracy of these routine laboratory indices in predicting liver fibrosis and cirrhosis. Results: Correlation analysis revealed a significant positive correlation between AGPR and liver fibrosis stage ( P < 0.001). In the training cohort, the AUROC of AGPR was 0.83 (95%CI: 0.78-0.87) for predicting fibrosis (≥ F2), 0.84 (95%CI: 0.79-0.88) for predicting extensive fibrosis (≥ F3), and 0.87 (95%CI: 0.83-0.91) for predicting cirrhosis (F4). In the validation cohort, the AUROCs of AGPR to predict ≥ F2, ≥ F3 and F4 were 0.83 (95%CI: 0.77-0.88), 0.83 (95%CI: 0.77-0.89), and 0.84 (95%CI: 0.78-0.89), respectively. Conclusion: The AGPR index should become a new, simple, accurate, and noninvasive marker to predict liver fibrosis and cirrhosis in chronic hepatitis B patients. Competing Interests: Conflict-of-interest statement: There are no conflicts of interest to report. (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| References: | Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S60-3. (PMID: 26206574) J Ultrasound Med. 2015 Mar;34(3):403-10. (PMID: 25715361) Kaohsiung J Med Sci. 2016 Jun;32(6):334-5. (PMID: 27377848) Hepatology. 1996 Aug;24(2):289-93. (PMID: 8690394) Gastroenterology. 1990 Nov;99(5):1396-400. (PMID: 2101588) Biomed Res Int. 2013;2013:614081. (PMID: 24151614) Gut. 2016 Aug;65(8):1369-76. (PMID: 26109530) Med J Armed Forces India. 2016 Apr;72(2):192-3. (PMID: 27257335) Clin Liver Dis. 2016 Nov;20(4):667-679. (PMID: 27742006) Hepatol Res. 2016 Aug;46(9):862-70. (PMID: 26763834) World J Gastroenterol. 2014 Jul 21;20(27):9026-37. (PMID: 25083076) BMC Surg. 2021 Feb 3;21(1):72. (PMID: 33536005) Medicine (Baltimore). 2016 Aug;95(35):e4679. (PMID: 27583895) J Gastroenterol Hepatol. 2017 Jun;32(6):1221-1229. (PMID: 27859587) Arq Gastroenterol. 2017 Jan-Mar;54(1):51-56. (PMID: 28079240) J Hepatol. 2019 Jan;70(1):151-171. (PMID: 30266282) PLoS One. 2014 Aug 28;9(8):e105728. (PMID: 25165830) J Gastroenterol Hepatol. 2015 Apr;30(4):756-62. (PMID: 25353058) J Hepatol. 2011 May;54(5):894-900. (PMID: 21145808) Medicine (Baltimore). 2016 Apr;95(16):e3372. (PMID: 27100421) Gastroenterology. 2009 Feb;136(2):477-85.e11. (PMID: 19100265) Clin Mol Hepatol. 2014 Dec;20(4):347-54. (PMID: 25548740) Curr Gastroenterol Rep. 2004 Feb;6(1):30-6. (PMID: 14720451) Mol Med Rep. 2015 Jun;11(6):4174-82. (PMID: 25651500) World J Gastroenterol. 2020 Dec 7;26(45):7088-7103. (PMID: 33362370) J Gastroenterol Hepatol. 2007 Oct;22(10):1621-6. (PMID: 17845689) Hepatology. 2003 Aug;38(2):518-26. (PMID: 12883497) Hepatology. 2006 Jun;43(6):1317-25. (PMID: 16729309) |
| فهرسة مساهمة: | Keywords: Chronic hepatitis B; Cirrhosis; Fibrosis; Liver; Novel noninvasive marker; Prediction |
| المشرفين على المادة: | 0 (Biomarkers) EC 2.3.2.2 (gamma-Glutamyltransferase) EC 2.6.1.1 (Aspartate Aminotransferases) EC 3.1.3.1 (Alkaline Phosphatase) |
| تواريخ الأحداث: | Date Created: 20220926 Date Completed: 20220928 Latest Revision: 20220928 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9346453 |
| DOI: | 10.3748/wjg.v28.i27.3503 |
| PMID: | 36158257 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-2840 |
|---|---|
| DOI: | 10.3748/wjg.v28.i27.3503 |