دورية أكاديمية
Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China.
العنوان: | Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China. |
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المؤلفون: | Liao MJ; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology and Hepatology Unit, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China., Li J; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China.; Genetics and Precision Medicine Laboratory, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Dang W; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Chen DB; Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Beijing 100044, China., Qin WY; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Chen P; Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Beijing 100044, China., Zhao BG; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Ren LY; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Xu TF; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China., Chen HS; Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Beijing 100044, China., Liao WJ; Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China. liaoweijia288@163.com. |
المصدر: | World journal of gastroenterology [World J Gastroenterol] 2022 Jul 21; Vol. 28 (27), pp. 3503-3513. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
مواضيع طبية MeSH: | Hepatitis B, Chronic*/complications , Hepatitis B, Chronic*/diagnosis , Hepatitis B, Chronic*/pathology, Alkaline Phosphatase ; Aspartate Aminotransferases ; Biomarkers ; China/epidemiology ; Humans ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/pathology ; Platelet Count ; ROC Curve ; Retrospective Studies ; gamma-Glutamyltransferase |
مستخلص: | Background: Noninvasive, practical, and convenient means of detection for the prediction of liver fibrosis and cirrhosis in China are greatly needed. Aim: To develop a precise noninvasive test to stage liver fibrosis and cirrhosis. Methods: With liver biopsy as the gold standard, we established a new index, [alkaline phosphatase (U/L) + gamma-glutamyl transpeptidase (U/L)/platelet (10 9 /L) (AGPR)], to predict liver fibrosis and cirrhosis. In addition, we compared the area under the receiver operating characteristic curve (AUROC) of AGPR, gamma-glutamyl transpeptidase to platelet ratio, aspartate transaminase to platelet ratio index, and FIB-4 and evaluated the accuracy of these routine laboratory indices in predicting liver fibrosis and cirrhosis. Results: Correlation analysis revealed a significant positive correlation between AGPR and liver fibrosis stage ( P < 0.001). In the training cohort, the AUROC of AGPR was 0.83 (95%CI: 0.78-0.87) for predicting fibrosis (≥ F2), 0.84 (95%CI: 0.79-0.88) for predicting extensive fibrosis (≥ F3), and 0.87 (95%CI: 0.83-0.91) for predicting cirrhosis (F4). In the validation cohort, the AUROCs of AGPR to predict ≥ F2, ≥ F3 and F4 were 0.83 (95%CI: 0.77-0.88), 0.83 (95%CI: 0.77-0.89), and 0.84 (95%CI: 0.78-0.89), respectively. Conclusion: The AGPR index should become a new, simple, accurate, and noninvasive marker to predict liver fibrosis and cirrhosis in chronic hepatitis B patients. Competing Interests: Conflict-of-interest statement: There are no conflicts of interest to report. (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.) |
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فهرسة مساهمة: | Keywords: Chronic hepatitis B; Cirrhosis; Fibrosis; Liver; Novel noninvasive marker; Prediction |
المشرفين على المادة: | 0 (Biomarkers) EC 2.3.2.2 (gamma-Glutamyltransferase) EC 2.6.1.1 (Aspartate Aminotransferases) EC 3.1.3.1 (Alkaline Phosphatase) |
تواريخ الأحداث: | Date Created: 20220926 Date Completed: 20220928 Latest Revision: 20220928 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9346453 |
DOI: | 10.3748/wjg.v28.i27.3503 |
PMID: | 36158257 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2219-2840 |
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DOI: | 10.3748/wjg.v28.i27.3503 |