دورية أكاديمية
أعرض في EDS

Warty carcinoma of the uterine cervix: a virus-induced disease?

التفاصيل البيبلوغرافية
العنوان: Warty carcinoma of the uterine cervix: a virus-induced disease?
المؤلفون: Yordanov AD; Department of Gynaecological Oncology, Medical University Pleven, Pleven, Bulgaria., Ivanov I; Department of General and Clinical Pathology, Medical University Pleven, Pleven, Bulgaria., Dineva T; Scientific Laboratory, Department of Epidemiology, Medical University Pleven, Pleven, Bulgaria., Slavchev S; Department of Gynaecology, Medical University Varna, Varna, Bulgaria., Kostov S; Department of Gynaecology, Medical University Varna, Varna, Bulgaria., Strashilov S; Department of Plastic and Reconstructive Surgery, MU-Pleven, Pleven, Bulgaria., Konsoulova A; Complex Oncological Centre Burgas, Burgas, Bulgaria.
المصدر: Archives of medical science : AMS [Arch Med Sci] 2020 Aug 06; Vol. 18 (5), pp. 1248-1252. Date of Electronic Publication: 2020 Aug 06 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Termedia Pub. House Country of Publication: Poland NLM ID: 101258257 Publication Model: eCollection Cited Medium: Print ISSN: 1734-1922 (Print) Linking ISSN: 17341922 NLM ISO Abbreviation: Arch Med Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Poznań, Poland] : Termedia Pub. House, [2005]-
مستخلص: Introduction: Warty carcinoma (WC) of the uterine cervix is a rare subtype of squamous-cell carcinoma (SCC), and its frequency, clinical behaviour, and aetiology are obscure. It originates from condylomas, and a viral carcinogenesis seems logical.
Material and Methods: Retrospective analysis was performed of all cervical carcinomas (CC), diagnosed at a single institution for a 10-year period. Analysed patients had stage I carcinoma. Patients with WC were identified, and their tumour samples were tested for high-risk HPV (hr-HPV) and EBV, using PCR and ISH. Clinical characteristics and WC rates across all stage I CC patients were assessed. All patients had minimum 3-year follow-up, and overall survival (OS) and 5-year survival rates were calculated.
Results: WC comprised 2.2% of all stage I CC ( n = 630). The mean age of the patients was 48 years (range: 29-72). The primary tumour size was 2 cm in 4 (28.6%) patients, 2-4 cm in 2 (14.3%) patients, and 4 cm in 8 (57.1%) patients. Lymph node metastasis was found in 1 (7.1%) patient. EBV or hr-HPV were detected in 2 (18.2%) patients using ISH, with no coinfection reported. Hr-HPV was detected in 2 (18.2%) patients; EBV in 4 (36.4%) cases, and in 2 of them (18.2%) there was a co-infection. Thirteen patients had a follow-up of ≥ 5 years and their 5-year OS was 100%.
Conclusions: WC is a rare subtype of SCC with good prognosis, regardless of viral status. In contrast to SCC, its aetiology is not related to hr-HPV. The role of EBV remains unclear and cannot currently be denied.
Competing Interests: The authors declare no conflict of interest.
(Copyright: © 2020 Termedia & Banach.)
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فهرسة مساهمة: Keywords: Epstein-Barr virus; aetiology; human papillomavirus; in situ hybridisation; polymerase chain reaction; warty carcinoma
تواريخ الأحداث: Date Created: 20220926 Latest Revision: 20220928
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9479728
DOI: 10.5114/aoms.2020.97997
PMID: 36160345
قاعدة البيانات: MEDLINE
الوصف
تدمد:1734-1922
DOI:10.5114/aoms.2020.97997