دورية أكاديمية
أعرض في EDS

Thrombotic Microangiopathy Due to Progressive Disseminated Histoplasmosis in a Child With Down Syndrome and Acute Lymphoblastic Leukemia.

التفاصيل البيبلوغرافية
العنوان: Thrombotic Microangiopathy Due to Progressive Disseminated Histoplasmosis in a Child With Down Syndrome and Acute Lymphoblastic Leukemia.
المؤلفون: Cowfer BA; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN., Hunley TE; Division of Pediatric Nephrology, Department of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN., Mason EF; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN., Dulek DE; Division of Pediatric Infectious Disease, Department of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN., Benedetti DJ; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Vanderbilt University Medical Center and Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN.
المصدر: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2023 Jan 01; Vol. 45 (1), pp. 38-40. Date of Electronic Publication: 2022 Sep 22.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505928 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-3678 (Electronic) Linking ISSN: 10774114 NLM ISO Abbreviation: J Pediatr Hematol Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, NY : Raven Press, c1995-
مواضيع طبية MeSH: Histoplasmosis*/complications , Histoplasmosis*/diagnosis , Histoplasmosis*/therapy , Down Syndrome*/complications , Thrombotic Microangiopathies*/etiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/complications, Female ; Humans ; Child ; Child, Preschool ; Amphotericin B/therapeutic use
مستخلص: Histoplasmosis, a common mycosis in the south-central United States, may be life threatening in immunocompromised patients. We describe a 4-year-old female with Down syndrome and acute lymphoblastic leukemia who developed hemolytic anemia, thrombocytopenia, and renal failure, consistent with thrombotic microangiopathy. Bone marrow biopsy revealed non-necrotizing granulomas with GMS staining demonstrating budding yeast. Serum Histoplasma antigen testing was positive, providing further evidence for the diagnosis of progressive disseminated histoplasmosis. Treatment with amphotericin B, plasma exchange, and ventilator, vasopressor, and renal replacement support led to a full recovery. Providers should have a low threshold for histoplasmosis testing in ill immunocompromised patients, who are at greater risk for infection-related morbidity.
Competing Interests: The authors declare no conflict of interest.
(Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
References: Wattier RL, Dvorak CC, Hoffman JA, et al. A prospective, international cohort study of invasive mold infections in children. J Pediatr Infect Dis Soc. 2015;4:313–322.
Mochi A, Edwards PQ. Geographical distribution of histoplasmosis and histoplasmin sensitivity. Bull World Health Organ. 1952;5:259–291.
Wheat LJ. Risk factors for disseminated or fatal histoplasmosis: analysis of a large urban outbreak. Ann Intern Med. 1982;96:159.
Adderson EE. Histoplasmosis in a pediatric oncology center. J Pediatr. 2004;144:100–106.
Kauffman CA, Israel KS, Smith JW, et al. Histoplasmosis in immunosuppressed patients. Am J Med. 1978;64:923–932.
Hess J, Fondell A, Fustino N, et al. Presentation and treatment of histoplasmosis in pediatric oncology patients: case series and review of the literature. J Pediatr Hematol Oncol. 2017;39:137–140.
Sethi S. Acute renal failure in a renal allograft: an unusual infectious cause of thrombotic microangiopathy. Am J Kidney Dis Off J Natl Kidney Found. 2005;46:159–162.
Dwyre DM, Bell AM, Siechen K, et al. Disseminated histoplasmosis presenting as thrombotic microangiopathy. Transfusion. 2006;46:1221–1225.
Iwamoto N, Yoshioka T, Nitta K, et al. Glomerular endothelial injury associated with free radical production induced by a fungal cell wall component, (1→3) β-D Glucan. Life Sci. 1997;62:247–255.
Weitz IC. Thrombotic microangiopathy in cancer. Semin Thromb Hemost. 2019;45:348–353.
Thomas MR, Scully M. How I treat microangiopathic hemolytic anemia in patients with cancer. Blood. 2021;137:1310–1317.
Kanchi H, Webb NJ, Eden OB. Hemolytic uremic syndrome secondary to the treatment of acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2000;22:483–484.
Cheng G, Ozgonenel B, Bhambhani K, et al. Recurrent atypical hemolytic uremic syndrome in children with acute lymphoblastic leukemia undergoing maintenance chemotherapy. J Pediatr Hematol Oncol. 2018;40:560–562.
Turudic D, Milosevic D, Bilic K, et al. A limited course of Eculizumab in a child with the atypical hemolytic uremic syndrome and pre-B acute lymphoblastic leukemia on maintenance therapy: case report and literature review. J Clin Med. 2022;11:2779.
Ratnoff WD, Pepple JM, Winkelstein JA. Activation of the alternative complement pathway by Histoplasma capsulatum . Infect Immun. 1980;30:147–149.
Fisher BT, Robinson PD, Lehrnbecher T, et al. Risk factors for invasive fungal disease in pediatric cancer and hematopoietic stem cell transplantation: a systematic review. J Pediatr Infect Dis Soc. 2018;7:191–198.
Huggard D, Doherty DG, Molloy EJ. Immune dysregulation in children with Down syndrome. Front Pediatr. 2020;8:73.
Patrick K, Wade R, Goulden N, et al. Outcome of Down syndrome associated acute lymphoblastic leukaemia treated on a contemporary protocol. Br J Haematol. 2014;165:552–555.
Azar M, Hage C. Clinical perspectives in the diagnosis and management of histoplasmosis—ClinicalKey. Clin Chest Med. 2017;38:403–415.
Tobón AM, Franco L, Espinal D, et al. Disseminated histoplasmosis in children: the role of itraconazole therapy. Pediatr Infect Dis J. 1996;15:1002–1008.
Ceppi F, Stephens D, Hollander BS den, et al. Clinical presentation and risk factors of serious infections in children with Down syndrome treated for acute lymphoblastic leukemia. Pediatr Blood Cancer. 2016;63:1949–1953.
Ashraf N, Kubat RC, Poplin V, et al. Re-drawing the maps for endemic mycoses. Mycopathologia. 2020;185:843–865.
Ouellette CP, Stanek JR, Leber A, et al. Pediatric histoplasmosis in an area of endemicity: a contemporary analysis. J Pediatr Infect Dis Soc. 2019;8:400–407.
Hage CA, Ribes JA, Wengenack NL, et al. A multicenter evaluation of tests for diagnosis of histoplasmosis. Clin Infect Dis Off Publ Infect Dis Soc Am. 2011;53:448–454.
المشرفين على المادة: 7XU7A7DROE (Amphotericin B)
تواريخ الأحداث: Date Created: 20220926 Date Completed: 20230106 Latest Revision: 20230202
رمز التحديث: 20240628
DOI: 10.1097/MPH.0000000000002556
PMID: 36162003
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-3678
DOI:10.1097/MPH.0000000000002556