دورية أكاديمية
Characteristics of appendicitis after immune checkpoint inhibitor therapy among cancer patients.
العنوان: | Characteristics of appendicitis after immune checkpoint inhibitor therapy among cancer patients. |
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المؤلفون: | Mathew A; Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA., Shatila M; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lai Z; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tan D; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Oliva ICG; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang J; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Alhalabi O; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang HC; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Thomas A; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang Y; Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ywang59@mdanderson.org. |
المصدر: | Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Jul; Vol. 149 (8), pp. 4591-4599. Date of Electronic Publication: 2022 Sep 26. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag. |
مواضيع طبية MeSH: | Appendicitis*/surgery , Appendicitis*/chemically induced , Appendicitis*/drug therapy , Antineoplastic Agents, Immunological*/therapeutic use , Neoplasms*/drug therapy, Adult ; Humans ; Middle Aged ; Immune Checkpoint Inhibitors/adverse effects ; Retrospective Studies |
مستخلص: | Purpose: Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer care but is associated with immune-related adverse events (irAEs). Recent case reports raised the concern that acute appendicitis may be an irAE. In this study, we sought to describe the disease course of post-ICI therapy appendicitis and its associated complications. Methods: Adult patients who had an International Classification of Diseases code for appendicitis within the first 2 years after initiating ICI therapy from January 2010 to April 2021 and who had imaging evidence of appendicitis were studied retrospectively. Results: 13,991 patients were identified who had ICI exposure during the study period, 44 had codes for appendicitis, 10 of whom met the inclusion criteria. Their median age at the time of diagnosis was 59 years. The median time from ICI therapy initiation to appendicitis onset was 188 days. The most common presenting symptoms were abdominal pain (70%) and fever (40%). Abscesses were present in two patients, and a perforation was present in one. All 10 patients received broad-spectrum antibiotics. Five patients needed surgery or interventional radiology drainage. Nine patients had resolution of appendicitis symptoms after treatment. Conclusion: Post-ICI therapy appendicitis is rare but presents similarly to and has similar complications rates as conventional appendicitis. Appendectomy remains the mainstay of treatment, but its use can be limited in cancer patients. The decision to continue ICI therapy remains at the discretion of the clinician. Further studies are needed to bring awareness to and advance the understanding of this clinical entity. (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Adverse events; Appendicitis; Cancer; Immune checkpoint inhibitor |
المشرفين على المادة: | 0 (Immune Checkpoint Inhibitors) 0 (Antineoplastic Agents, Immunological) |
تواريخ الأحداث: | Date Created: 20220927 Date Completed: 20230719 Latest Revision: 20230719 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/s00432-022-04367-6 |
PMID: | 36163559 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-1335 |
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DOI: | 10.1007/s00432-022-04367-6 |