دورية أكاديمية
Structural characterization and immunoregulatory activity of a neutral polysaccharide from the roots of Apocynum venetum L.
| العنوان: | Structural characterization and immunoregulatory activity of a neutral polysaccharide from the roots of Apocynum venetum L. |
|---|---|
| المؤلفون: | Liu D; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: liud000@nenu.edu.cn., Wang SY; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: wangsy171@nenu.edu.cn., Wang GN; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: wanggn258@nenu.edu.cn., Zheng LH; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: zhenglh015@nenu.edu.cn., Sun Y; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: suny040@nenu.edu.cn., Liu L; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: liul905@nenu.edu.cn., Bao YL; National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China. Electronic address: baoyl800@nenu.edu.cn. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2022 Dec 01; Vol. 222 (Pt A), pp. 90-100. Date of Electronic Publication: 2022 Sep 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Apocynum*, Mice ; Animals ; Polysaccharides/pharmacology ; Polysaccharides/chemistry ; Mannans ; Plant Roots ; Molecular Weight |
| مستخلص: | The structural characteristics and immunoregulatory activities of neutral heteropolysaccharide (AVRP-N) separated from the roots of Apocynum venetum L. were extensively investigated. The results showed that the weight average molecular mass (Mw) of AVRP-N was 6.430 × 10 3 Da. Moreover, the backbone is composed of natural acetylated (1 → 4)-β-D-Man and (1 → 5)-α-L-Ara domains. The mannan is composed of →4)-β-D-Manp-(1→, →4)-β-D-Glcp-(1→, and the terminal group α-D-Galp-(1→ attached to →4,6)-β-D-Manp-(1→ at O-6. Araban is composed of →5)-α-L-Araf-(1→; the terminal group α-L-Araf-(1→attached to→2,3,5)-α-L-Araf-(1→ at O-2, O-3 and →3,5)-α-L-Araf-(1→ at O-3. In addition, the senior structure shows that AVRP-N has a triple-helix conformation. Furthermore, AVRP-N exhibited immunomodulatory effects, which could significantly regulate the proliferation of mouse splenic lymphocytes by enhancing the secretion of the cytokines (IFN-γ, IL-2, IL-4, and IL-10). Our results provide new structural and immunoregulatory information for natural polysaccharides derived from Apocynum venetum L. Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Apocynum venetum L.; Immunoregulation; Polysaccharide; Roots; Structural characterization |
| المشرفين على المادة: | 0 (Polysaccharides) 0 (Mannans) |
| تواريخ الأحداث: | Date Created: 20220927 Date Completed: 20221109 Latest Revision: 20221109 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ijbiomac.2022.09.158 |
| PMID: | 36165870 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
|---|---|
| DOI: | 10.1016/j.ijbiomac.2022.09.158 |