دورية أكاديمية
Exposure to acetaminophen impairs gametogenesis and fertility in zebrafish (Danio rerio).
| العنوان: | Exposure to acetaminophen impairs gametogenesis and fertility in zebrafish (Danio rerio). |
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| المؤلفون: | Moreira DP; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil., Ribeiro YM; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil., Ferreira CS; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil., Dos Santos Nassif Lacerda SM; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil., Rizzo E; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil. ictio@icb.ufmg.br. |
| المصدر: | Archives of toxicology [Arch Toxicol] 2023 Jan; Vol. 97 (1), pp. 263-278. Date of Electronic Publication: 2022 Sep 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Zebrafish*/metabolism , Water Pollutants, Chemical*/toxicity , Water Pollutants, Chemical*/metabolism, Animals ; Female ; Male ; Acetaminophen/metabolism ; Semen Analysis ; Follicular Atresia ; Semen ; Gametogenesis ; Estradiol/metabolism ; Gonadal Steroid Hormones/metabolism ; Gonadal Steroid Hormones/pharmacology ; Reproduction ; Fertility |
| مستخلص: | Acetaminophen (ACE; paracetamol) is one of the most widely used nonsteroidal anti-inflammatory drugs worldwide and is often found in aquatic systems, where it can act on nontarget species and impair fish reproduction. This study aimed to investigate the effects of chronic exposure to environmentally relevant ACE concentrations (0.5, 5 and 50 µg/L) on multiple reproductive parameters in zebrafish (Danio rerio). Gametogenesis was analyzed using histology, morphometry, cell proliferation, and apoptosis. This study also evaluated sex steroids, and prostaglandin E (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| معلومات مُعتمدة: | 310283/2020-5 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 001 Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| فهرسة مساهمة: | Keywords: Acetaminophen; Endocrine disruptor; Estrogen receptors; Fish; Hormones; Subfertility |
| المشرفين على المادة: | 362O9ITL9D (Acetaminophen) 4TI98Z838E (Estradiol) 0 (Gonadal Steroid Hormones) 0 (Water Pollutants, Chemical) |
| تواريخ الأحداث: | Date Created: 20220928 Date Completed: 20230109 Latest Revision: 20230118 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00204-022-03390-3 |
| PMID: | 36167911 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-0738 |
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| DOI: | 10.1007/s00204-022-03390-3 |