دورية أكاديمية
Exposure to acetaminophen impairs gametogenesis and fertility in zebrafish (Danio rerio).
العنوان: | Exposure to acetaminophen impairs gametogenesis and fertility in zebrafish (Danio rerio). |
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المؤلفون: | Moreira DP; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil., Ribeiro YM; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil., Ferreira CS; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil., Dos Santos Nassif Lacerda SM; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil., Rizzo E; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, UFMG, Belo Horizonte, Minas Gerais, Brazil. ictio@icb.ufmg.br. |
المصدر: | Archives of toxicology [Arch Toxicol] 2023 Jan; Vol. 97 (1), pp. 263-278. Date of Electronic Publication: 2022 Sep 27. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
مواضيع طبية MeSH: | Zebrafish*/metabolism , Water Pollutants, Chemical*/toxicity , Water Pollutants, Chemical*/metabolism, Animals ; Female ; Male ; Acetaminophen/metabolism ; Semen Analysis ; Follicular Atresia ; Semen ; Gametogenesis ; Estradiol/metabolism ; Gonadal Steroid Hormones/metabolism ; Gonadal Steroid Hormones/pharmacology ; Reproduction ; Fertility |
مستخلص: | Acetaminophen (ACE; paracetamol) is one of the most widely used nonsteroidal anti-inflammatory drugs worldwide and is often found in aquatic systems, where it can act on nontarget species and impair fish reproduction. This study aimed to investigate the effects of chronic exposure to environmentally relevant ACE concentrations (0.5, 5 and 50 µg/L) on multiple reproductive parameters in zebrafish (Danio rerio). Gametogenesis was analyzed using histology, morphometry, cell proliferation, and apoptosis. This study also evaluated sex steroids, and prostaglandin E (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
References: | Aksu EH, Özkaraca M, Kandemir FM et al (2016) Mitigation of paracetamol-induced reproductive damage by chrysin in male rats via reducing oxidative stress. Andrologia 48:1145–1154. https://doi.org/10.1111/and.12553. (PMID: 10.1111/and.12553) Ayobahan SU, Eilebrecht S, Baumann L et al (2020) Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics. Chemosphere 240:1–12. https://doi.org/10.1016/j.chemosphere.2019.124970. (PMID: 10.1016/j.chemosphere.2019.124970) Baker SJC, Corrigan E, Melnyk N et al (2021) Nuclear progesterone receptor regulates ptger4b and PLA2G4A expression in zebrafish (Danio rerio) ovulation. Gen Comp Endocrinol 311:113842. https://doi.org/10.1016/j.ygcen.2021.113842. (PMID: 10.1016/j.ygcen.2021.113842) Banihani SA (2017) Effect of paracetamol on semen quality. Andrologia 1:1–4. https://doi.org/10.1111/and.12874. (PMID: 10.1111/and.12874) Banihani SA (2019) Effect of aspirin on semen quality: a review. Andrologia 52:3–8. https://doi.org/10.1111/and.13487. (PMID: 10.1111/and.13487) Banihani SA, Shatnawi RM (2020) Aspirin decreases human sperm motility and vitality, chelates seminal calcium, but insignificantly reduces seminal nitric oxide production. Andrologia 52:1–8. https://doi.org/10.1111/and.13776. (PMID: 10.1111/and.13776) Baumann L, Holbech H, Schmidt-Posthaus H et al (2020) Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)? Chemosphere 238:124589. https://doi.org/10.1016/j.chemosphere.2019.124589. (PMID: 10.1016/j.chemosphere.2019.124589) Bertotto LB, Richards J, Gan J et al (2018) Effects of bifenthrin exposure on the estrogenic and dopaminergic pathways in zebrafish embryos and juveniles. Environ Toxicol Chem 37:236–246. https://doi.org/10.1002/etc.3951. (PMID: 10.1002/etc.3951) Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254. (PMID: 10.1016/0003-2697(76)90527-3) Campanha MB, Awan AT, Mozeto AA, Fadini PS (2015) A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil. Environ Sci Pollut Res. https://doi.org/10.1007/s11356-014-3929-x. (PMID: 10.1007/s11356-014-3929-x) Crespo D, Lemos MS, Zhang YT et al (2020) PGE2 inhibits spermatogonia differentiation in zebrafish: interaction with Fsh and an androgen. J Endocrinol 244:163–175. https://doi.org/10.1530/JOE-19-0309. (PMID: 10.1530/JOE-19-0309) Crowder CM, Lassiter CS, Gorelick DA (2018) Nuclear androgen receptor regulates testes organization and oocyte maturation in zebrafish. Endocrinology 159:980–993. https://doi.org/10.1210/en.2017-00617. (PMID: 10.1210/en.2017-00617) Dean A, Van Den DS, Wang Y et al (2016) Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences. Sci Rep. https://doi.org/10.1038/srep19789. (PMID: 10.1038/srep19789) Flint S, Markle T, Thompson S, Wallace E (2012) Bisphenol A exposure, effects, and policy: a wildlife perspective. J Environ Manag 104:19–34. https://doi.org/10.1016/j.jenvman.2012.03.021. (PMID: 10.1016/j.jenvman.2012.03.021) Galus M, Jeyaranjaan J, Smith E et al (2013a) Chronic effects of exposure to a pharmaceutical mixture and municipal wastewater in zebrafish. Aquat Toxicol 132–133:212–222. https://doi.org/10.1016/j.aquatox.2012.12.016. (PMID: 10.1016/j.aquatox.2012.12.016) Galus M, Kirischian N, Higgins S et al (2013b) Chronic, low concentration exposure to pharmaceuticals impacts multiple organ systems in zebrafish. Aquat Toxicol 132–133:200–211. https://doi.org/10.1016/j.aquatox.2012.12.021. (PMID: 10.1016/j.aquatox.2012.12.021) Gómez MJ, Martínez Bueno MJ, Lacorte S et al (2007) Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. Chemosphere 66:993–1002. https://doi.org/10.1016/j.chemosphere.2006.07.051. (PMID: 10.1016/j.chemosphere.2006.07.051) González-Rojo S, Lombó M, Fernández-Díez C, Herráez MP (2019) Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes. Environ Pollut 248:368–379. https://doi.org/10.1016/j.envpol.2019.01.127. (PMID: 10.1016/j.envpol.2019.01.127) Gottlieb C, Svanborg K, Eneroth P, Bygdeman M (1988) Effect of prostaglandins on human sperm function in vitro and seminal adenosine triphosphate content. Fertil Steril 49:322–327. https://doi.org/10.1016/s0015-0282(16)59723-4. (PMID: 10.1016/s0015-0282(16)59723-4) Guiloski I, Ribas J, Piancini L et al (2017) Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure. Environ Toxicol Pharmacol 53:111–120. (PMID: 10.1016/j.etap.2017.05.005) Lau SM, McGuire TM, Van Driel ML (2016) Consumer concerns about paracetamol: a retrospective analysis of a medicines call centre. BMJ Open 6:1–8. https://doi.org/10.1136/bmjopen-2015-010860. (PMID: 10.1136/bmjopen-2015-010860) Legrand A, Albert O, Lesne L et al (2013) Paracetamol, aspirin and indomethacin display endocrine disrupting properties in the adult human testis in vitro. Hum Reprod 28:1890–1898. https://doi.org/10.1093/humrep/det112. (PMID: 10.1093/humrep/det112) Lister AL, Van Der Kraak G (2008) An investigation into the role of prostaglandins in zebrafish oocyte maturation and ovulation. Gen Comp Endocrinol 159:46–57. https://doi.org/10.1016/j.ygcen.2008.07.017. (PMID: 10.1016/j.ygcen.2008.07.017) Liu W, Xin Q, Wang X et al (2017) Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals. Cell Death Dis 8:1–11. https://doi.org/10.1038/cddis.2017.82. (PMID: 10.1038/cddis.2017.82) Lubzens E, Young G, Bobe J, Cerdà J (2010) Oogenesis in teleosts: how fish eggs are formed. Gen Comp Endocrinol 165:367–389. https://doi.org/10.1016/j.ygcen.2009.05.022. (PMID: 10.1016/j.ygcen.2009.05.022) Melo RMC, Martins YS, Luz RK et al (2015) PCNA and apoptosis during post-spawning ovarian remodeling in the teleost Oreochromis niloticus. Tissue Cell 47:541–549. https://doi.org/10.1016/j.tice.2015.10.002. (PMID: 10.1016/j.tice.2015.10.002) Morais RDVS, Crespo D, Nóbrega RH et al (2017) Antagonistic regulation of spermatogonial differentiation in zebrafish (Danio rerio) by Igf3 and Amh. Mol Cell Endocrinol 454:112–124. https://doi.org/10.1016/j.mce.2017.06.017. (PMID: 10.1016/j.mce.2017.06.017) Morthorst JE, Lister A, Bjerregaard P, Der Van Kraak G (2013) Ibuprofen reduces zebrafish PGE2 levels but steroid hormone levels and reproductive parameters are not affected. Comp Biochem Physiol C Toxicol Pharmacol 157:251–257. https://doi.org/10.1016/j.cbpc.2012.12.001. (PMID: 10.1016/j.cbpc.2012.12.001) Nelson ER, Habibi HR (2013) Estrogen receptor function and regulation in fish and other vertebrates. Gen Comp Endocrinol 192:15–24. https://doi.org/10.1016/j.ygcen.2013.03.032. (PMID: 10.1016/j.ygcen.2013.03.032) Ogiwara K, Takahashi T (2016) A dual role for melatonin in medaka ovulation: ensuring prostaglandin synthesis and actin cytoskeleton rearrangement in follicular cells. Biol Reprod 94:1–15. https://doi.org/10.1095/biolreprod.115.133827. (PMID: 10.1095/biolreprod.115.133827) Paschoalini AL, Savassi LA, Weber AA et al (2021) Evaluation of the oestrogenic potential of oestrone and bisphenol-A on the reproduction of Astyanax bimaculatus males after subacute exposure. Fish Physiol Biochem 47:797–810. https://doi.org/10.1007/s10695-021-00938-5. (PMID: 10.1007/s10695-021-00938-5) Poleo GA, Denniston RS, Reggio BC et al (2001) Fertilization of eggs of zebrafish, Danio rerio, by intracytoplasmic sperm injection. Biol Reprod 65:961–966. https://doi.org/10.1095/biolreprod65.3.961. (PMID: 10.1095/biolreprod65.3.961) Przybyła GW, Szychowski KA, Gmiński J (2021) Paracetamol—an old drug with new mechanisms of action. Clin Exp Pharmacol Physiol 48:3–19. https://doi.org/10.1111/1440-1681.13392. (PMID: 10.1111/1440-1681.13392) Qie Y, Qin W, Zhao K et al (2021) Environmental estrogens and their biological effects through GPER mediated signal pathways. Environ Pollut 278:116826. https://doi.org/10.1016/j.envpol.2021.116826. (PMID: 10.1016/j.envpol.2021.116826) Ribeiro YM, de Matos SA, Domingos FFT et al (2017) Germ cell proliferation and apoptosis during testicular regression in a seasonal breeding fish kept in captivity. Tissue Cell 49:664–671. https://doi.org/10.1016/j.tice.2017.09.003. (PMID: 10.1016/j.tice.2017.09.003) Riesco MF, Robles V (2013) Cryopreservation causes genetic and epigenetic changes in zebrafish genital ridges. PLoS ONE 8:1–9. https://doi.org/10.1371/journal.pone.0067614. (PMID: 10.1371/journal.pone.0067614) Rios M, Carreño DV, Oses C et al (2016) Low physiological levels of prostaglandins E2 and F2α improve human sperm functions. Reprod Fertil Dev 28:434–439. https://doi.org/10.1071/RD14035. (PMID: 10.1071/RD14035) Schulz RW, de França LR, Lareyre JJ et al (2010) Spermatogenesis in fish. Gen Comp Endocrinol 165:390–411. https://doi.org/10.1016/j.ygcen.2009.02.013. (PMID: 10.1016/j.ygcen.2009.02.013) Takahashi T, Hagiwara A, Ogiwara K (2018) Prostaglandins in teleost ovulation: a review of the roles with a view to comparison with prostaglandins in mammalian ovulation. Mol Cell Endocrinol 461:236–247. https://doi.org/10.1016/j.mce.2017.09.019. (PMID: 10.1016/j.mce.2017.09.019) Tang H, Liu Y, Li J et al (2016) Gene knockout of nuclear progesterone receptor provides insights into the regulation of ovulation by LH signaling in zebrafish. Sci Rep 6:1–11. https://doi.org/10.1038/srep28545. (PMID: 10.1038/srep28545) Taylor SC, Nadeau K, Abbasi M et al (2019) The ultimate qPCR experiment: producing publication quality, reproducible data the first time. Trends Biotechnol 37:761–774. https://doi.org/10.1016/j.tibtech.2018.12.002. (PMID: 10.1016/j.tibtech.2018.12.002) Thomé RG, Domingos FFT, Santos HB et al (2012) Apoptosis, cell proliferation and vitellogenesis during the folliculogenesis and follicular growth in teleost fish. Tissue Cell 44:54–62. https://doi.org/10.1016/j.tice.2011.11.002. (PMID: 10.1016/j.tice.2011.11.002) Vliegenthart ADB, Tucker CS, Del PJ, Dear JW (2014) Zebrafish as model organisms for studying drug-induced liver injury. Br J Clin Pharmacol 78:1217–1227. https://doi.org/10.1111/bcp.12408. (PMID: 10.1111/bcp.12408) Weber AA, Moreira DP, Melo RMC et al (2017) Reproductive effects of oestrogenic endocrine disrupting chemicals in Astyanax rivularis inhabiting headwaters of the Velhas River, Brazil. Sci Total Environ 592:693–703. https://doi.org/10.1016/j.scitotenv.2017.02.181. (PMID: 10.1016/j.scitotenv.2017.02.181) Weber AA, Moreira DP, Melo RMC et al (2019) Environmental exposure to oestrogenic endocrine disruptors mixtures re fl ecting on gonadal sex steroids and gametogenesis of the neotropical fish Astyanax rivularis. Gen Comp Endocrinol 279:99–108. https://doi.org/10.1016/j.ygcen.2018.12.016. (PMID: 10.1016/j.ygcen.2018.12.016) Zheng Q, Xiao H, Shi H et al (2020) Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone. J Endocrinol 244:487–499. https://doi.org/10.1530/JOE-19-0438. (PMID: 10.1530/JOE-19-0438) Żur J, Piński A, Marchlewicz A et al (2018) Organic micropollutants paracetamol and ibuprofen—toxicity, biodegradation, and genetic background of their utilization by bacteria. Environ Sci Pollut Res 25:21498–21524. https://doi.org/10.1007/s11356-018-2517-x. (PMID: 10.1007/s11356-018-2517-x) |
معلومات مُعتمدة: | 310283/2020-5 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 001 Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
فهرسة مساهمة: | Keywords: Acetaminophen; Endocrine disruptor; Estrogen receptors; Fish; Hormones; Subfertility |
المشرفين على المادة: | 362O9ITL9D (Acetaminophen) 4TI98Z838E (Estradiol) 0 (Gonadal Steroid Hormones) 0 (Water Pollutants, Chemical) |
تواريخ الأحداث: | Date Created: 20220928 Date Completed: 20230109 Latest Revision: 20230118 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/s00204-022-03390-3 |
PMID: | 36167911 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-0738 |
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DOI: | 10.1007/s00204-022-03390-3 |