دورية أكاديمية
Morphological, ultrastructural, and biochemical changes induced by sodium fluoride in the tongue of adult male albino rat and the ameliorative effect of resveratrol.
| العنوان: | Morphological, ultrastructural, and biochemical changes induced by sodium fluoride in the tongue of adult male albino rat and the ameliorative effect of resveratrol. |
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| المؤلفون: | El-Bestawy EM; Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Sharqia Governorate, Egypt., Tolba AM; Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Sharqia Governorate, Egypt., Rashad WA; Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Sharqia Governorate, Egypt. |
| المصدر: | Anatomy & cell biology [Anat Cell Biol] 2022 Dec 31; Vol. 55 (4), pp. 483-496. Date of Electronic Publication: 2022 Sep 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Association of Anatomists Country of Publication: Korea (South) NLM ID: 101531987 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2093-3665 (Print) Linking ISSN: 20933665 NLM ISO Abbreviation: Anat Cell Biol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul, South Korea : Korean Association of Anatomists |
| مستخلص: | Little knowledge is available about the effects of fluoride exposure on the tongue. This study evaluated the effects of sodium fluoride (NaF) on the tongue ultrastructure and detected the ameliorative effects of resveratrol. Forty adult albino rats were separated into 4 groups: the control group was given a balanced diet and purified water. The NaF treated group: received 10 mg/kg/d dissolved in 2.5 ml distilled water once daily for 30 days orally. The NaF+resveratrol group: received NaF 10 mg/kg/d orally together with resveratrol in a dose of 30 mg/kg daily for 30 days. The resveratrol group was subjected to resveratrol in a dose of 30 mg/kg/d by oral gavage for 30 days. Sections were stained with hematoxylin & eosin, and Masson's trichrome. Tumor necrosis factor α immunohistochemical study and electron microscopic examinations were done. The oxidative stress markers malondialdehyde, antioxidant reduced glutathione, and the total antioxidant capacity were measured. The NaF group revealed ulceration, necrotic muscle fibers, distorted papillae and a significant increase in malondialdehyde level, and a significant decrease in glutathione and the total antioxidant levels. In the NaF+resveratrol group, pathological changes were less, and the oxidant levels were decreased by the administration of resveratrol with NaF. In conclusion, NaF adversely affects the ultrastructure of the adult rat tongue and resveratrol can ameliorate this effect. |
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| فهرسة مساهمة: | Keywords: Electron microscopy; Rat; Resveratrol; Sodium flouride; Tongue |
| تواريخ الأحداث: | Date Created: 20220928 Latest Revision: 20230101 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9747341 |
| DOI: | 10.5115/acb.22.088 |
| PMID: | 36168808 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2093-3665 |
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| DOI: | 10.5115/acb.22.088 |