دورية أكاديمية

أعرض في EDS

SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner.

التفاصيل البيبلوغرافية
العنوان:	SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner.
المؤلفون:	Saccon TD; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Mousovich-Neto F; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Ludwig RG; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Carregari VC; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Dos Anjos Souza AB; Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Dos Passos ASC; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil., Martini MC; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Barbosa PP; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., de Souza GF; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Muraro SP; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Forato J; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Amorim MR; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Marques RE; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP, Brazil., Veras FP; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil.; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil., Barreto E; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil., Gonçalves TT; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil.; Department of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil., Paiva IM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil., Fazolini NPB; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Onodera CMK; Hematology-Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., Martins Junior RB; Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., de Araújo PHC; Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Batah SS; Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Viana RMM; Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., de Melo DM; Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Fabro AT; Department of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Arruda E; Virology Research Center, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil., Queiroz Cunha F; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil., Cunha TM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil., Pretti MAM; Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil., Smith BJ; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Marques-Souza H; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Knittel TL; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Ruiz GP; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Profeta GS; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Fontes-Cal TCM; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil., Boroni M; Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil., Vinolo MAR; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil., Farias AS; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil., Moraes-Vieira PMM; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil., Bizzacchi JMA; Hematology-Hemotherapy Center, University of Campinas, Campinas, SP, Brazil., Teesalu T; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Chaim FDM; Department of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil., Cazzo E; Department of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil., Chaim EA; Department of Surgery, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil., Proença-Módena JL; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil., Martins-de-Souza D; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil. dmsouza@unicamp.br.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil. dmsouza@unicamp.br.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil. dmsouza@unicamp.br.; D'Or Institute for Research and Education (IDOR), São Paulo, SP, Brazil. dmsouza@unicamp.br.; Instituto Nacional de Biomarcadores em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, São Paulo, SP, Brazil. dmsouza@unicamp.br., Osako MK; Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. mko@fmrp.usp.br., Leiria LO; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil. luizleiria@usp.br.; Center for Research in Inflammatory Diseases, Ribeirão Preto, SP, Brazil. luizleiria@usp.br., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil. morima@unicamp.br.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil. morima@unicamp.br.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil. morima@unicamp.br.; Instituto Nacional de Obesidade e Diabetes, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Campinas, SP, Brazil. morima@unicamp.br.
المصدر:	Nature communications [Nat Commun] 2022 Sep 29; Vol. 13 (1), pp. 5722. Date of Electronic Publication: 2022 Sep 29.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH:	COVID-19* , SARS-CoV-2*, Adipose Tissue ; Angiotensin-Converting Enzyme 2 ; Cytokines ; Humans
مستخلص:	Visceral adiposity is a risk factor for severe COVID-19, and a link between adipose tissue infection and disease progression has been proposed. Here we demonstrate that SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells. However, susceptibility to infection and the cellular response depends on the anatomical origin of the cells and the viral lineage. Visceral fat cells express more ACE2 and are more susceptible to SARS-CoV-2 infection than their subcutaneous counterparts. SARS-CoV-2 infection leads to inhibition of lipolysis in subcutaneous fat cells, while in visceral fat cells, it results in higher expression of pro-inflammatory cytokines. Viral load and cellular response are attenuated when visceral fat cells are infected with the SARS-CoV-2 gamma variant. A similar degree of cell death occurs 4-days after SARS-CoV-2 infection, regardless of the cell origin or viral lineage. Hence, SARS-CoV-2 infects human fat cells, replicating and altering cell function and viability in a depot- and viral lineage-dependent fashion. (© 2022. The Author(s).)
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المشرفين على المادة:	0 (Cytokines) EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
SCR Organism:	SARS-CoV-2 variants
تواريخ الأحداث:	Date Created: 20220929 Date Completed: 20221003 Latest Revision: 20221128
رمز التحديث:	20221213
مُعرف محوري في PubMed:	PMC9521555
DOI:	10.1038/s41467-022-33218-8
PMID:	36175400
قاعدة البيانات:	MEDLINE

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تدمد:	2041-1723
DOI:	10.1038/s41467-022-33218-8