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Hippocampal neurogenesis promotes effortful responding but does not regulate effort-based choice.

التفاصيل البيبلوغرافية
العنوان: Hippocampal neurogenesis promotes effortful responding but does not regulate effort-based choice.
المؤلفون: Seib DR; Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Princz-Lebel O; Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Chahley ER; Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Floresco SB; Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Snyder JS; Department of Psychology, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
المصدر: Hippocampus [Hippocampus] 2022 Nov; Vol. 32 (11-12), pp. 818-827. Date of Electronic Publication: 2022 Sep 30.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9108167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1063 (Electronic) Linking ISSN: 10509631 NLM ISO Abbreviation: Hippocampus Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley
Original Publication: New York, NY : Churchill Livingstone, c1991-
مواضيع طبية MeSH: Neurogenesis* , Reward*, Humans ; Rats ; Animals ; Hippocampus ; Motivation ; Sugars ; Choice Behavior/physiology
مستخلص: A fundamental trait of depression is low motivation. Hippocampal neurogenesis has been associated with motivational deficits but detailed evidence on how it regulates human-relevant behavioral traits is still missing. We used the hGFAP-TK rat model to deplete actively dividing neural stem cells in the rat hippocampus. Use of the effort-discounting operant task allowed us to identify specific and detailed deficits in motivation behavior. In this task, rats are given a choice between small and large food rewards, where 2-20 lever presses are required to obtain the large reward (four sugar pellets) versus one press to receive the smaller reward (two sugar pellets). We found that depleting adult neurogenesis did not affect effort-based choice or general motivation to complete the task. However, lack of adult neurogenesis reduced the pressing rate and thus increased time to complete the required presses to obtain a reward. In summary, the present study finds that adult hippocampal neurogenesis specifically reduces response vigor to obtain rewards and thus deepens our understanding in how neurogenesis shapes depression.
(© 2022 Wiley Periodicals LLC.)
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معلومات مُعتمدة: Canada CIHR
فهرسة مساهمة: Keywords: adult neurogenesis; depression; hippocampus; motivation; reward
المشرفين على المادة: 0 (Sugars)
تواريخ الأحداث: Date Created: 20220930 Date Completed: 20221121 Latest Revision: 20230105
رمز التحديث: 20240628
DOI: 10.1002/hipo.23472
PMID: 36177887
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-1063
DOI:10.1002/hipo.23472