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Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte.

التفاصيل البيبلوغرافية
العنوان: Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte.
المؤلفون: Xue Y; Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Reproductive Science Institute, Taiyuan, China.; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Meng TG; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Ouyang YC; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Liu SL; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Guo JN; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Wang ZB; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Schatten H; Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA., Song CY; Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Reproductive Science Institute, Taiyuan, China., Guo XP; Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Reproductive Science Institute, Taiyuan, China., Sun QY; Fertility Preservation Lab, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, China.
المصدر: Journal of cellular physiology [J Cell Physiol] 2022 Dec; Vol. 237 (12), pp. 4477-4486. Date of Electronic Publication: 2022 Oct 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley-Liss
Original Publication: Philadelphia, Wistar Institute of Anatomy and Biology.
مواضيع طبية MeSH: Meiosis* , Mitochondria*/physiology , Oocytes*/physiology , rho GTP-Binding Proteins*/physiology, Animals ; Female ; Mice ; Pregnancy ; Homeostasis ; Oogenesis
مستخلص: Miro1, a mitochondrial Rho GTPase1, is a kind of mitochondrial outer membrane protein involved in the regulation of mitochondrial anterograde transport and its subcellular distribution. Mitochondria influence reproductive processes of mammals in some aspects. Mitochondria are important for oocyte maturation, fertilization and embryonic development. The purpose of this study was to evaluate whether Miro1 regulates mouse oocyte maturation by altering mitochondrial homeostasis. We showed that Miro1 was expressed in mouse oocyte at different maturation stages. Miro1 mainly distributed in the cytoplasm and around the spindle during oocyte maturation. Small interference RNA-mediated Miro1 depletion caused significantly abnormal distribution of mitochondria and endoplasmic reticulum as well as mitochondrial dysfunction, resulting in severely impaired germinal vesicle breakdown (GVBD) of mouse oocytes. For those oocytes which went through GVBD in the Miro1-depleted group, part of them were inhibited in meiotic prophase I stage with abnormal chromosome arrangement and scattered spindle length. Our results suggest that Miro1 is essential for maintaining the maturation potential of mouse oocyte.
(© 2022 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: Miro1; Mitochondria; meiosis; oocyte
المشرفين على المادة: 0 (Miro-1 protein, mouse)
EC 3.6.5.2 (rho GTP-Binding Proteins)
تواريخ الأحداث: Date Created: 20221002 Date Completed: 20221220 Latest Revision: 20221222
رمز التحديث: 20221222
DOI: 10.1002/jcp.30890
PMID: 36183380
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4652
DOI:10.1002/jcp.30890