دورية أكاديمية
Dose-Response Absorption Kinetics of Oral L-Beta-Aminoisobutyric Acid (L-BAIBA) Supplementation in Healthy Men and Women.
العنوان: | Dose-Response Absorption Kinetics of Oral L-Beta-Aminoisobutyric Acid (L-BAIBA) Supplementation in Healthy Men and Women. |
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المؤلفون: | Krieger JM; Exercise and Performance Nutrition Laboratory, College of Science, Technology, and Health, Lindenwood University, St. Charles, MO, USA., Hagele AM; Exercise and Performance Nutrition Laboratory, College of Science, Technology, and Health, Lindenwood University, St. Charles, MO, USA., Orr LS; Exercise and Performance Nutrition Laboratory, College of Science, Technology, and Health, Lindenwood University, St. Charles, MO, USA., Walden KE; Exercise and Performance Nutrition Laboratory, College of Science, Technology, and Health, Lindenwood University, St. Charles, MO, USA., Gross KN; Exercise and Performance Nutrition Laboratory, College of Science, Technology, and Health, Lindenwood University, St. Charles, MO, USA., Mumford PW; Exercise and Performance Nutrition Laboratory, College of Science, Technology, and Health, Lindenwood University, St. Charles, MO, USA., Kerksick CM; Exercise and Performance Nutrition Laboratory, College of Science, Technology, and Health, Lindenwood University, St. Charles, MO, USA. |
المصدر: | Journal of dietary supplements [J Diet Suppl] 2023; Vol. 20 (6), pp. 832-849. Date of Electronic Publication: 2022 Oct 02. |
نوع المنشور: | Randomized Controlled Trial; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101249830 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-022X (Electronic) Linking ISSN: 19390211 NLM ISO Abbreviation: J Diet Suppl Subsets: MEDLINE |
أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, NY : Informa Healthcare |
مواضيع طبية MeSH: | Aminoisobutyric Acids* , Dietary Supplements*, Female ; Humans ; Male ; Polyesters ; Valine ; Young Adult ; Adult |
مستخلص: | L-Beta-amino isobutyric acid (L-BAIBA) is a myokine produced in skeletal muscle during exercise and has been shown to impact carbohydrate and fat metabolism in both animals and humans. This study was designed to determine the rate and extent to which L-BAIBA appeared in human plasma after oral ingestion. In a randomized, double-blind, placebo-controlled, crossover fashion, six males and 6 females ( N = 12; 24 ± 5 yrs; 173.6 ± 12.0 cm; 72.3 ± 11.3 kg; 21.0 ± 7.0 body fat %) completed a single-dose supplementation protocol of placebo (PLA), L-BAIBA at 250 mg (B250), 500 mg (B500), 1,500mg (B1500), and 1,500mg of valine (V1500). Participants fasted overnight (8-10 h) and consumed their dose with 8-12 fluid ounces of cold water. Venous blood samples were collected 0, 30, 60, 90, 120, 180, 240 and 300 min after ingestion and analyzed for L-BAIBA. Complete blood counts and comprehensive metabolic panels were analyzed 0 and 300 min after ingestion. Peak concentration (C |
فهرسة مساهمة: | Keywords: L-BAIBA; absorption; amino acid; myokine; supplements; valine |
سلسلة جزيئية: | ClinicalTrials.gov NCT05328271 |
المشرفين على المادة: | T68ALE2O9F (3-aminoisobutyric acid) 0 (Aminoisobutyric Acids) 0 (Polyesters) HG18B9YRS7 (Valine) |
تواريخ الأحداث: | Date Created: 20221002 Date Completed: 20231026 Latest Revision: 20231026 |
رمز التحديث: | 20231026 |
DOI: | 10.1080/19390211.2022.2128141 |
PMID: | 36184601 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1939-022X |
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DOI: | 10.1080/19390211.2022.2128141 |