دورية أكاديمية
Orbitofrontal cortex populations are differentially recruited to support actions.
| العنوان: | Orbitofrontal cortex populations are differentially recruited to support actions. |
|---|---|
| المؤلفون: | Cazares C; The Neurosciences Graduate Program, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA., Schreiner DC; Department of Psychology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA., Valencia ML; Department of Psychology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA., Gremel CM; The Neurosciences Graduate Program, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA; Department of Psychology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. Electronic address: cgremel@ucsd.edu. |
| المصدر: | Current biology : CB [Curr Biol] 2022 Nov 07; Vol. 32 (21), pp. 4675-4687.e5. Date of Electronic Publication: 2022 Oct 03. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: London, UK : Current Biology Ltd., c1991- |
| مواضيع طبية MeSH: | Prefrontal Cortex* , Reward*, Mice ; Animals |
| مستخلص: | The ability to use information from one's prior actions is necessary for decision-making. While orbitofrontal cortex (OFC) has been hypothesized as key for inferences made using cue and value-related information, whether OFC populations contribute to the use of information from volitional actions to guide behavior is not clear. Here, we used a self-paced lever-press hold-down task in which mice infer prior lever-press durations to guide subsequent action performance. We show that the activity of genetically identified lateral OFC (lOFC) subpopulations differentially instantiate current and prior action information during ongoing action execution. Transient state-dependent lOFC circuit disruptions of specified subpopulations reduced the encoding of ongoing press durations but did not disrupt the use of prior action information to guide future action performance. In contrast, a chronic functional loss of lOFC circuit activity resulted in increased reliance on recently executed lever-press durations and impaired contingency reversal, suggesting the recruitment of compensatory mechanisms that resulted in repetitive action control. Our results identify a novel role for lOFC in the integration of action information to guide adaptive behavior. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Curr Biol. 2022 Nov 7;32(21):R1231-R1233. (PMID: 36347231) |
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| معلومات مُعتمدة: | F31 AA027439 United States AA NIAAA NIH HHS; F99 NS120434 United States NS NINDS NIH HHS; R01 AA026077 United States AA NIAAA NIH HHS |
| فهرسة مساهمة: | Keywords: action; experience; fiber photometry; goal-directed; orbitofrontal cortex; parvalbumin; reward |
| تواريخ الأحداث: | Date Created: 20221004 Date Completed: 20221110 Latest Revision: 20231108 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9643660 |
| DOI: | 10.1016/j.cub.2022.09.022 |
| PMID: | 36195096 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1879-0445 |
|---|---|
| DOI: | 10.1016/j.cub.2022.09.022 |