دورية أكاديمية
Orbitofrontal cortex populations are differentially recruited to support actions.
العنوان: | Orbitofrontal cortex populations are differentially recruited to support actions. |
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المؤلفون: | Cazares C; The Neurosciences Graduate Program, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA., Schreiner DC; Department of Psychology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA., Valencia ML; Department of Psychology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA., Gremel CM; The Neurosciences Graduate Program, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA; Department of Psychology, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. Electronic address: cgremel@ucsd.edu. |
المصدر: | Current biology : CB [Curr Biol] 2022 Nov 07; Vol. 32 (21), pp. 4675-4687.e5. Date of Electronic Publication: 2022 Oct 03. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge, MA : Cell Press Original Publication: London, UK : Current Biology Ltd., c1991- |
مواضيع طبية MeSH: | Prefrontal Cortex* , Reward*, Mice ; Animals |
مستخلص: | The ability to use information from one's prior actions is necessary for decision-making. While orbitofrontal cortex (OFC) has been hypothesized as key for inferences made using cue and value-related information, whether OFC populations contribute to the use of information from volitional actions to guide behavior is not clear. Here, we used a self-paced lever-press hold-down task in which mice infer prior lever-press durations to guide subsequent action performance. We show that the activity of genetically identified lateral OFC (lOFC) subpopulations differentially instantiate current and prior action information during ongoing action execution. Transient state-dependent lOFC circuit disruptions of specified subpopulations reduced the encoding of ongoing press durations but did not disrupt the use of prior action information to guide future action performance. In contrast, a chronic functional loss of lOFC circuit activity resulted in increased reliance on recently executed lever-press durations and impaired contingency reversal, suggesting the recruitment of compensatory mechanisms that resulted in repetitive action control. Our results identify a novel role for lOFC in the integration of action information to guide adaptive behavior. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
التعليقات: | Comment in: Curr Biol. 2022 Nov 7;32(21):R1231-R1233. (PMID: 36347231) |
References: | Neuroscience. 2021 Apr 15;460:53-68. (PMID: 33609638) Nature. 2016 Apr 28;532(7600):459-64. (PMID: 27074502) J Neurosci. 2021 May 12;41(19):4160-4168. (PMID: 33893217) Cell. 2022 Mar 17;185(6):1065-1081.e23. (PMID: 35245431) Elife. 2021 Oct 25;10:. (PMID: 34693908) Elife. 2019 Apr 23;8:. (PMID: 31012845) Ann N Y Acad Sci. 2011 Dec;1239:59-70. (PMID: 22145876) Brain Cogn. 2004 Jun;55(1):11-29. (PMID: 15134840) Neuron. 2015 Dec 16;88(6):1268-1280. (PMID: 26627312) Science. 2014 Aug 1;345(6196):1255263. (PMID: 25082707) Neuron. 2016 Jun 15;90(6):1312-1324. (PMID: 27238866) Nat Rev Neurosci. 2020 May;21(5):247-263. (PMID: 32231315) Neuron. 2014 Jan 22;81(2):267-279. (PMID: 24462094) Elife. 2019 Nov 18;8:. (PMID: 31736463) Ann N Y Acad Sci. 2007 Dec;1121:54-71. (PMID: 17698999) Curr Opin Neurobiol. 2012 Dec;22(6):1075-81. (PMID: 22959354) J Neurosci. 2017 Feb 22;37(8):2010-2021. (PMID: 28115481) Front Integr Neurosci. 2009 Oct 09;3:23. (PMID: 19847323) J Neurosci. 1999 Aug 1;19(15):6610-4. (PMID: 10414988) Infect Immun. 2005 Apr;73(4):1907-16. (PMID: 15784530) Behav Neurosci. 2021 Apr;135(2):267-276. (PMID: 34060879) Behav Neurosci. 2017 Jun;131(3):201-212. (PMID: 28541078) Annu Rev Neurosci. 2019 Jul 8;42:459-483. (PMID: 31018098) Curr Biol. 2020 Aug 3;30(15):R860-R865. (PMID: 32750340) Nature. 2006 Jun 15;441(7095):876-9. (PMID: 16778890) Philos Trans R Soc Lond B Biol Sci. 2021 Mar;376(1819):20190664. (PMID: 33423634) Neuroreport. 2002 May 7;13(6):885-90. (PMID: 11997707) Neuron. 2006 Aug 17;51(4):509-20. (PMID: 16908415) Neuron. 2007 Apr 5;54(1):51-8. (PMID: 17408577) J Neurosci. 2011 Oct 19;31(42):15048-52. (PMID: 22016538) Nat Neurosci. 2019 Jul;22(7):1110-1121. (PMID: 31160741) Neuron. 2011 Oct 20;72(2):231-43. (PMID: 22017986) Transl Psychiatry. 2014 Sep 09;4:e436. (PMID: 25203167) Curr Opin Behav Sci. 2021 Oct;41:45-49. (PMID: 34056054) Nat Neurosci. 2019 Oct;22(10):1544-1553. (PMID: 31551597) J Neurosci. 2012 Apr 18;32(16):5534-48. (PMID: 22514315) Neuron. 2019 Oct 9;104(1):47-62. (PMID: 31600515) Front Mol Neurosci. 2020 Feb 06;13:14. (PMID: 32116547) Front Neuroinform. 2015 Apr 08;9:7. (PMID: 25904861) Cell. 2013 May 9;153(4):896-909. (PMID: 23663785) Neuron. 2016 Sep 21;91(6):1402-1412. (PMID: 27657452) Nature. 2014 Jan 16;505(7483):318-26. (PMID: 24429630) Trends Cogn Sci. 2012 Jan;16(1):43-51. (PMID: 22138231) Nat Neurosci. 2019 May;22(5):762-769. (PMID: 30962632) J Neurosci. 2004 Aug 25;24(34):7540-8. (PMID: 15329401) Nat Rev Neurosci. 2016 Aug;17(8):513-23. (PMID: 27256552) Neuropsychopharmacology. 2010 Jan;35(1):48-69. (PMID: 19776734) J Neurosci. 2008 Aug 13;28(33):8338-43. (PMID: 18701696) Science. 2012 Nov 16;338(6109):953-6. (PMID: 23162000) Elife. 2018 Jun 13;7:. (PMID: 29897332) Eur J Neurosci. 2013 Aug;38(3):2382-8. (PMID: 23651226) J Neurosci. 2007 May 2;27(18):4819-25. (PMID: 17475789) Behav Brain Res. 2006 Jan 30;166(2):189-96. (PMID: 16153716) J Neurosci. 2008 May 7;28(19):5127-38. (PMID: 18463266) Elife. 2018 Jul 25;7:. (PMID: 30044220) Neuron. 2022 Apr 20;110(8):1318-1326.e4. (PMID: 35108498) Nat Rev Neurosci. 2022 Jul;23(7):428-438. (PMID: 35468999) Neuron. 2014 Mar 5;81(5):1140-1151. (PMID: 24529981) Neuron. 2021 Aug 4;109(15):2485-2498.e5. (PMID: 34171290) Nat Commun. 2018 Jan 15;9(1):211. (PMID: 29335427) Learn Mem. 2003 Mar-Apr;10(2):129-40. (PMID: 12663751) Nat Neurosci. 2014 Nov;17(11):1574-82. (PMID: 25262496) Neuropharmacology. 1998 Apr-May;37(4-5):407-19. (PMID: 9704982) Cell. 2018 Jun 28;174(1):44-58.e17. (PMID: 29779950) J Neurophysiol. 2015 Dec;114(6):3374-85. (PMID: 26467523) Nat Neurosci. 2016 Dec;19(12):1733-1742. (PMID: 27749828) Behav Anal (Wash D C). 2019 May;19(2):202-212. (PMID: 31588411) Nat Neurosci. 2005 Dec;8(12):1704-11. (PMID: 16286932) Nat Commun. 2017 Mar 24;8:14823. (PMID: 28337990) Behav Neurosci. 2021 Apr;135(2):255-266. (PMID: 34060878) Nat Rev Neurosci. 2020 Feb;21(2):80-92. (PMID: 31911627) J Neurosci. 1999 Jul 1;19(13):5473-81. (PMID: 10377356) Nat Commun. 2013;4:2264. (PMID: 23921250) Nat Rev Neurosci. 2014 Jun;15(6):410-24. (PMID: 24840803) Neuron. 2019 Apr 3;102(1):27-47. (PMID: 30946823) Elife. 2021 Jun 18;10:. (PMID: 34142660) J Comp Neurol. 2018 Jun 15;526(9):1498-1526. (PMID: 29524205) Nature. 2006 May 11;441(7090):223-6. (PMID: 16633341) Curr Opin Neurobiol. 2011 Aug;21(4):579-86. (PMID: 21641793) J Exp Anal Behav. 1973 Mar;19(2):239-50. (PMID: 4716170) Sci Rep. 2018 Jul 20;8(1):10979. (PMID: 30030509) Elife. 2018 Mar 07;7:. (PMID: 29513220) PLoS One. 2014 Nov 11;9(11):e112750. (PMID: 25386837) J Neurosci. 2013 Feb 20;33(8):3380-9. (PMID: 23426666) Am J Psychiatry. 2021 May 1;178(5):459-468. (PMID: 33726523) Eur J Neurosci. 2009 Nov;30(10):1941-6. (PMID: 19912335) eNeuro. 2021 Apr 20;8(2):. (PMID: 33785522) Nat Commun. 2022 Apr 19;13(1):2134. (PMID: 35440120) Nat Rev Neurosci. 2008 Dec;9(12):934-46. (PMID: 19020512) Cereb Cortex. 2018 Jul 1;28(7):2313-2325. (PMID: 28541407) Neuron. 2022 Jun 1;110(11):1869-1879.e5. (PMID: 35390278) J Neurosci. 2008 Dec 17;28(51):13775-85. (PMID: 19091968) Ann N Y Acad Sci. 2011 Dec;1239:51-8. (PMID: 22145875) Cereb Cortex. 2000 Mar;10(3):220-42. (PMID: 10731218) J Neurosci. 2013 Jan 30;33(5):1864-71. (PMID: 23365226) Nature. 2008 Jul 17;454(7202):340-4. (PMID: 18563088) Nature. 2009 Jun 4;459(7247):698-702. (PMID: 19396159) Nat Neurosci. 2016 Jul;19(7):973-80. (PMID: 27273768) Nat Commun. 2014 Jun 04;5:3926. (PMID: 24894805) |
معلومات مُعتمدة: | F31 AA027439 United States AA NIAAA NIH HHS; F99 NS120434 United States NS NINDS NIH HHS; R01 AA026077 United States AA NIAAA NIH HHS |
فهرسة مساهمة: | Keywords: action; experience; fiber photometry; goal-directed; orbitofrontal cortex; parvalbumin; reward |
تواريخ الأحداث: | Date Created: 20221004 Date Completed: 20221110 Latest Revision: 20231108 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9643660 |
DOI: | 10.1016/j.cub.2022.09.022 |
PMID: | 36195096 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1879-0445 |
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DOI: | 10.1016/j.cub.2022.09.022 |