دورية أكاديمية
Cathelicidin as a marker for subclinical cardiac changes and microvascular complications in children and adolescents with type 1 diabetes.
العنوان: | Cathelicidin as a marker for subclinical cardiac changes and microvascular complications in children and adolescents with type 1 diabetes. |
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المؤلفون: | Matter RM; Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Nasef MWA; Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt., ShibaAlhamd RM; Egypt Ministry of Health and Population, Cairo, Egypt., Thabet RA; Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt. |
المصدر: | Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2022 Oct 06; Vol. 35 (12), pp. 1509-1517. Date of Electronic Publication: 2022 Oct 06 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 9508900 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2191-0251 (Electronic) Linking ISSN: 0334018X NLM ISO Abbreviation: J Pediatr Endocrinol Metab Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Mar. 2011- : Berlin : Walter de Gruyter Original Publication: London : Freund Pub. House, [1995- |
مواضيع طبية MeSH: | Diabetes Mellitus, Type 1*/complications, Humans ; Adolescent ; Child ; Carotid Intima-Media Thickness ; Biomarkers ; Cholesterol ; Cathelicidins |
مستخلص: | Objectives: To detect cathelicidin levels in pediatric patients with type 1 diabetes (T1D) as a potential marker for diabetic vascular complications and to assess its relation to diastolic dysfunction as an index for subclinical macrovasculopathy. Methods: Totally, 84 patients with T1D were categorized into three groups; newly diagnosed diabetes group (28 patients with a mean age of 12.38 ± 1.99) years, T1D without microvascular complications group (28 patients with a mean age of 13.04 ± 2.27), and T1D with microvascular complications group (28 patients with a mean age of 13.96 ± 2.30). Patients were evaluated using serum cathelicidin levels and echocardiography. Results: Total cholesterol, microalbuminuria, and cathelicidin levels were significantly higher in patients with microvascular complications when compared to the other two groups (p<0.001). Additionally, carotid intima-media thickness (CIMT) echocardiography values and diastolic functions were significantly higher in patients with complications (p<0.001). Cathelicidin was positively correlated to the duration of diabetes (r=0.542, p<0.001), total cholesterol (r=0.346, p=0.001), recurrence of hypoglycemia (r=0.351, p=0.001), recurrence of diabetes ketoacidosis (r=0.365, p=0.001), CIMT (r=0.544, p<0.001), and E/A values (r=0.405, p<0.001). Conclusions: Serum cathelicidin levels can be used as an early marker for the occurrence and progression of vascular complications in patients with T1D. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.) |
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فهرسة مساهمة: | Keywords: CIMT; T1D vascular complications; cathelicidin |
المشرفين على المادة: | 0 (Biomarkers) 97C5T2UQ7J (Cholesterol) 0 (Cathelicidins) |
تواريخ الأحداث: | Date Created: 20221005 Date Completed: 20221202 Latest Revision: 20221207 |
رمز التحديث: | 20221213 |
DOI: | 10.1515/jpem-2022-0421 |
PMID: | 36196598 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2191-0251 |
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DOI: | 10.1515/jpem-2022-0421 |