دورية أكاديمية
أعرض في EDS

Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output.

التفاصيل البيبلوغرافية
العنوان: Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output.
المؤلفون: Rommel MGE; Research Group Gene Modification in Stem Cells, Division of Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany., Walz L; Research Group Pathogenesis of Respiratory Viruses, Division Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany., Fotopoulou F; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany., Kohlscheen S; Research Group Gene Modification in Stem Cells, Division of Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany., Schenk F; Research Group Gene Modification in Stem Cells, Division of Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany., Miskey C; Research Group Transposition and Genome Engineering, Division of Medical Biotechnology, Paul-Ehrlich-Institute, 63225 Langen, Germany., Botezatu L; Research Group Transposition and Genome Engineering, Division of Medical Biotechnology, Paul-Ehrlich-Institute, 63225 Langen, Germany., Krebs Y; Research Group Pathogenesis of Respiratory Viruses, Division Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany., Voelker IM; Molecular Biotechnology and Gene Therapy, Paul-Ehrlich-Institute, 63225 Langen, Germany., Wittwer K; Research Group Pathogenesis of Respiratory Viruses, Division Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany., Holland-Letz T; Division of Biostatistics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Ivics Z; Research Group Transposition and Genome Engineering, Division of Medical Biotechnology, Paul-Ehrlich-Institute, 63225 Langen, Germany., von Messling V; Research Group Pathogenesis of Respiratory Viruses, Division Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany., Essers MAG; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany; Division of Inflammatory Stress in Stem Cells, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Milsom MD; Division of Experimental Hematology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), 69120 Heidelberg, Germany., Pfaller CK; Research Group Pathogenesis of Respiratory Viruses, Division Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany., Modlich U; Research Group Gene Modification in Stem Cells, Division of Veterinary Medicine, Paul-Ehrlich-Institute, 63225 Langen, Germany; Faculty of Medicine, Goethe University Frankfurt am Main, 60590 Frankfurt am Main, Germany. Electronic address: ute.modlich@pei.de.
المصدر: Cell reports [Cell Rep] 2022 Oct 04; Vol. 41 (1), pp. 111447.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Influenza A virus* , Influenza, Human*/metabolism, Animals ; Antiviral Agents/metabolism ; Cytokines/metabolism ; Endothelial Protein C Receptor/metabolism ; Hematopoiesis ; Humans ; Megakaryocytes/metabolism ; Mice ; Receptors, Interleukin-1/metabolism ; Thrombopoietin/metabolism
مستخلص: Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and progenitor cells (HSPCs) sense a non-systemic influenza A virus (IAV) infection via inflammatory cytokines. Irrespective of antiviral treatment or vaccination, at a certain threshold of IAV titer in the lung, CD41-positive hematopoietic stem cells (HSCs) enter the cell cycle while endothelial protein C receptor-positive CD41-negative HSCs remain quiescent. Active CD41-positive HSCs represent the source of megakaryocytes, while their multi-lineage reconstitution potential is reduced. This emergency megakaryopoiesis is thrombopoietin independent and attenuated in IAV-infected interleukin-1 receptor-deficient mice. Newly produced platelets during IAV infection are immature and hyper-reactive. After viral clearance, HSC quiescence is re-established. Our study reveals that non-systemic viral respiratory infection has an acute impact on HSCs via inflammatory cytokines to counteract IAV-induced thrombocytopenia.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: CP: Immunology; CP: Microbiology; cytokines; emergency megakaryopoiesis; hematopoietic stem cell activation; inflammation; influenza; platelet activation; respiratory virus infection; vaccination
المشرفين على المادة: 0 (Antiviral Agents)
0 (Cytokines)
0 (Endothelial Protein C Receptor)
0 (Receptors, Interleukin-1)
9014-42-0 (Thrombopoietin)
تواريخ الأحداث: Date Created: 20221005 Date Completed: 20221007 Latest Revision: 20221029
رمز التحديث: 20221213
DOI: 10.1016/j.celrep.2022.111447
PMID: 36198277
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2022.111447