دورية أكاديمية
Prospective characterization of incident hepatic steatosis in pediatric and adolescent patients after total pancreatectomy with islet autotransplantation.
| العنوان: | Prospective characterization of incident hepatic steatosis in pediatric and adolescent patients after total pancreatectomy with islet autotransplantation. |
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| المؤلفون: | Vieira Alves VP; Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Qiu L; Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Abu-El-Haija M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Tellez S; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Vitale DS; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Lin TK; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Tkach JA; Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Nathan JD; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Dillman JR; Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Trout AT; Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: andrew.trout@cchmc.org. |
| المصدر: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2022 Dec; Vol. 22 (8), pp. 1175-1180. Date of Electronic Publication: 2022 Sep 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Country of Publication: Switzerland NLM ID: 100966936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1424-3911 (Electronic) Linking ISSN: 14243903 NLM ISO Abbreviation: Pancreatology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : New Delhi : Elsevier India Original Publication: Basel ; New York : Karger, c2001- |
| مواضيع طبية MeSH: | Fatty Liver*/diagnostic imaging , Fatty Liver*/epidemiology , Fatty Liver*/etiology , Islets of Langerhans Transplantation*/adverse effects, Adult ; Humans ; Child ; Adolescent ; Female ; Pancreatectomy/adverse effects ; Transplantation, Autologous ; Prospective Studies ; Magnetic Resonance Imaging |
| مستخلص: | Background: Hepatic steatosis has been described as a common finding in adults following total pancreatectomy with islet autotransplantation (TPIAT) but it is unknown if this occurs in children and adolescents. Objectives: To define the frequency of post-TPIAT hepatic steatosis in a sample of children and adolescents and to identify clinical predictors of incident steatosis post-TPIAT. Methods: In this prospective study, consecutive participants at least 1-month post-TPIAT underwent a liver MRI with proton density fat fraction (PDFF) and blood draw at our pediatric academic medical center between April 2021 and January 2022. Comparison clinical pre-TPIAT liver MRI or ultrasound and insulin use and graft function data were extracted from the medical record. T-tests were used for the comparison of means across continuous variables between participants with and without post-TPIAT steatosis. Results: A total of 20 participants (mean: 13 ± 4 years; 12 female) were evaluated. Mean liver PDFF at research MRI was 7.4 ± 6.2% (range: 2-25%). Seven participants (35%) had categorical hepatic steatosis (PDFF>5%) post-TPIAT, five of whom had pre-TPIAT steatosis, reflecting a 13% (2/15; 95% CI: 2-40%) incidence of post-TPIAT steatosis. Participant characteristics were not significantly different between subgroups with and without post-TPIAT steatosis. Mean PDFF at research MRI was not different between graft function subgroups (7.5% optimal/good vs. 7.3% marginal/failure; p = .96). Conclusion: Our study shows a moderate prevalence but low incidence of hepatic steatosis in a small sample of children and adolescents post-TPIAT. This study raises questions about a causal relationship between TPIAT and hepatic steatosis. Competing Interests: Conflict of interest None of the authors report conflicts of interest relevant to this manuscript. (Copyright © 2022 IAP and EPC. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Adolescents; Children; Proton density fat fraction; TPIAT; Total pancreatectomy with islet autotransplantation |
| تواريخ الأحداث: | Date Created: 20221005 Date Completed: 20221206 Latest Revision: 20230106 |
| رمز التحديث: | 20230106 |
| DOI: | 10.1016/j.pan.2022.09.242 |
| PMID: | 36198489 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1424-3911 |
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| DOI: | 10.1016/j.pan.2022.09.242 |