دورية أكاديمية
أعرض في EDS

The role of miRNA-424 and miR-631 in various cancers: Focusing on drug resistance and sensitivity.

التفاصيل البيبلوغرافية
العنوان: The role of miRNA-424 and miR-631 in various cancers: Focusing on drug resistance and sensitivity.
المؤلفون: Najafi F; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran., Kelaye SK; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Kazemi B; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Foruzandeh Z; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Allahverdizadeh F; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Vakili S; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Rad KK; Department of Genetic, Science Faculty, Shahrekord University of Medical Sciences, Shahrekord, Iran., Derakhshani M; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Solali S; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: ssolali@gmail.com., Alivand MR; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: alivandm@tbzmed.ac.ir.
المصدر: Pathology, research and practice [Pathol Res Pract] 2022 Nov; Vol. 239, pp. 154130. Date of Electronic Publication: 2022 Sep 16.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE
أسماء مطبوعة: Publication: Stuttgart : Gustav Fischer Verlag
Original Publication: Stuttgart, New York, Fischer.
مواضيع طبية MeSH: Neoplasms*/drug therapy , Neoplasms*/genetics , MicroRNAs*/genetics , MicroRNAs*/metabolism, Humans ; Apoptosis ; Drug Resistance ; Gene Expression Regulation, Neoplastic/genetics
مستخلص: Background: However, advanced technologies have been developed in the treatment of various cancers, but the mortality rate from cancer is still very high. Drug resistance is a major problem for patients with cancer, which causes the treatment process to fail. In addition to inhibiting drug resistance, targeted therapy is also very important in treatment.
Main Body: Nowadays, miRNAs have gained increasing interest as they play a major role in both drug resistance and targeted therapy. MicroRNA (miRNA) is an important part of non-coding RNA that regulates gene expression at a post-transcriptional level. The prevailing studies about miRNA expression have been expanded into a variety of neoplasms. MiR-424 and miR-631 targets genes involved in various cellular processes and can participate in proliferation, differentiation, apoptosis, invasion, angiogenesis, and drug resistance and sensitivity.
Conclusion: In this study, we focus on the role of miR-424 and miR-631 in many cancer types by displaying the potential target genes associated with each cancer, as well as briefly describing the clinical uses of miR-424 and miR-631 as a diagnostic and predictive tool in malignancies.
Competing Interests: Competing Interests The authors declare no conflict of interest.
(Copyright © 2022 Elsevier GmbH. All rights reserved.)
فهرسة مساهمة: Keywords: Angiogenesis; Apoptosis; Cancer; Differentiation; Drug resistance; Invasion; MiR-424; MiR-631; MicroRNAs; Posttranscriptional; Proliferation
المشرفين على المادة: 0 (MicroRNAs)
0 (MIRN631 microRNA, human)
تواريخ الأحداث: Date Created: 20221006 Date Completed: 20221118 Latest Revision: 20221118
رمز التحديث: 20221213
DOI: 10.1016/j.prp.2022.154130
PMID: 36201929
قاعدة البيانات: MEDLINE
الوصف
تدمد:1618-0631
DOI:10.1016/j.prp.2022.154130