دورية أكاديمية
Clinical study on the efficacy of hepatitis B vaccination in hepatitis C virus related chronic liver diseases in Egypt.
| العنوان: | Clinical study on the efficacy of hepatitis B vaccination in hepatitis C virus related chronic liver diseases in Egypt. |
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| المؤلفون: | Hassnine AA; Department of Gastroenterology Hepatology and Tropical Medicine, Faculty of medicine, Minia University, Minia, Egypt. Electronic address: Alshiamaa.Ahmed@mu.edu.eg., Saber MA; Department of pharmaceutics and Clinical Pharmacy, Faculty of pharmacy, Minia University, Minia, Egypt., Fouad YM; Department of Gastroenterology Hepatology and Tropical Medicine, Faculty of medicine, Minia University, Minia, Egypt., Sarhan H; Department of pharmaceutics and Clinical Pharmacy, Faculty of pharmacy, Minia University, Minia, Egypt., Elsayed MM; Department of pharmaceutics and Clinical Pharmacy, Faculty of pharmacy, Sohag University, Sohag, Egypt., Zaki ZM; Department of Clinical pathology, Faculty of medicine, Minia University, Minia, Egypt., Abdelraheem EM; Department of Gastroenterology Hepatology and Tropical Medicine, Faculty of medicine, Minia University, Minia, Egypt., Abdelhalim SM; Department of Gastroenterology Hepatology and Tropical Medicine, Faculty of medicine, Minia University, Minia, Egypt., Elsayed AM; Department of Gastroenterology Hepatology and Tropical Medicine, Faculty of medicine, Minia University, Minia, Egypt. |
| المصدر: | Virus research [Virus Res] 2023 Jan 02; Vol. 323, pp. 198953. Date of Electronic Publication: 2022 Oct 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8410979 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7492 (Electronic) Linking ISSN: 01681702 NLM ISO Abbreviation: Virus Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science, c1984- |
| مستخلص: | Background: Chronic hepatitis B (HBV) and C virus (HCV) infections represent significant public health issues internationally. HBV vaccination has high sero-conversion rates in patients with mild to moderate chronic liver disease but has reduced efficacy in advanced stages. Aim: to evaluate the efficacy of hepatitis B vaccination in HCV-related chronic liver disease and identify possible factors that may contribute to hypo-responsiveness in those patients. Methods: Our study was a retrospective observational clinical study carried out at the tropical medicine department. It was conducted on 500 individuals (400 chronic HCV patients and 100 healthy controls). Individuals were divided into 5 groups: A (control group), B (cirrhotic patient not receiving treatment), C (chronic hepatitis patients receiving treatment), D (cirrhotic patients receiving treatment), and E (HCC patients receiving treatment). All individuals were subjected for comprehensive history taking, clinical examination, laboratory investigations, and assessment of anti-HBs titer. Results: There is an inverse relationship between the level of anti-HBs Abs and the duration of vaccine. Diabetes and presence of cirrhosis have statistically significant relationship with serum anti-HBs Abs titer (P = 0.007). Oral DAAs therapy is associated with reduced response to HBV vaccine (only 31.75% of the patients were protected). Conclusion: HCV infection and its complications significantly impair HBV vaccine response. Levels of anti-HBs Abs decline progressively with increasing duration from the last dose in immunization schedule of HBV vaccine. Diabetes and presence of cirrhosis being the main risk factors for vaccine hypo-responsiveness, also oral DAAs therapy is associated with reduced response to HBV vaccine. Competing Interests: Declaration of Competing Interests All authors declare no Conflict of interest (Copyright © 2022. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Chronic hepatitis B; DAAs; HCV; Liver cirrhosis; Vaccine response |
| تواريخ الأحداث: | Date Created: 20221009 Latest Revision: 20231019 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10194353 |
| DOI: | 10.1016/j.virusres.2022.198953 |
| PMID: | 36209916 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7492 |
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| DOI: | 10.1016/j.virusres.2022.198953 |