دورية أكاديمية
أعرض في EDS

Impact of increasing antimüllerian hormone level on in vitro fertilization fresh transfer and live birth rate.

التفاصيل البيبلوغرافية
العنوان: Impact of increasing antimüllerian hormone level on in vitro fertilization fresh transfer and live birth rate.
المؤلفون: Acharya KS; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina., Harris BS; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina., Weber JM; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Truong T; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Pieper C; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina., Eaton JL; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.; Women & Infants Fertility Center, Providence, Rhode Island.
المصدر: F&S reports [F S Rep] 2022 Jun 30; Vol. 3 (3), pp. 223-230. Date of Electronic Publication: 2022 Jun 30 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101766618 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3341 (Electronic) Linking ISSN: 26663341 NLM ISO Abbreviation: F S Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier Inc., [2020]-
مستخلص: Objective: The objective of our study was to assess the association between AMH and live birth among women with elevated AMH undergoing first fresh IVF. Serum antimüllerian hormone (AMH) correlates with oocyte yield during in vitro fertilization (IVF). However, there are limited data regarding IVF outcomes in women with elevated AMH levels.
Design: Retrospective cohort study using the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System database from 2012-2014.
Setting: Fertility clinics reporting to Society for Assisted Reproductive Technology.
Patients: First, fresh, autologous IVF cycles with elevated AMH levels (≥5.0 ng/mL). Subanalyses were performed to examine patients with or without polycystic ovary syndrome (PCOS).
Interventions: None.
Main Outcome Measures: Odds of live birth.
Results: Our cohort included 10,615 patients with elevated an AMH level, including 2,707 patients with PCOS only. The adjusted odds of live birth per initiated cycle were significantly lower per each unit increase in the AMH level (odds ratio, 0.97; 95% confidence interval, 0.96-0.98). Increasing AMH level was associated with increased cancellation of fresh transfer (odds ratio, 1.12; 95% confidence interval, 1.10-1.15) up to an AMH level of 12 ng/mL. The decrease in the live birth rate appears to be caused by the increasing incidence of cancellation of fresh transfer because the live birth rate per completed transfer was maintained. Similar trends were observed in the PCOS and non-PCOS subanalyses.
Conclusions: Among patients with AMH levels of ≥5 ng/mL undergoing fresh, autologous IVF, each unit increase in AMH level is associated with a 3% decrease in odds of live birth because of the increased incidence of fresh embryo transfer cancellation.
(© 2022 The Authors.)
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فهرسة مساهمة: Keywords: AMH; IVF outcomes; PCOS; live birth
تواريخ الأحداث: Date Created: 20221010 Latest Revision: 20240209
رمز التحديث: 20240209
مُعرف محوري في PubMed: PMC9532892
DOI: 10.1016/j.xfre.2022.06.005
PMID: 36212572
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-3341
DOI:10.1016/j.xfre.2022.06.005