دورية أكاديمية
أعرض في EDS

Extranuclear effects of thyroid hormones and analogs during development: An old mechanism with emerging roles.

التفاصيل البيبلوغرافية
العنوان: Extranuclear effects of thyroid hormones and analogs during development: An old mechanism with emerging roles.
المؤلفون: Incerpi S; Department of Sciences, University Roma Tre, Roma, Italy., Gionfra F; Department of Sciences, University Roma Tre, Roma, Italy., De Luca R; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., Candelotti E; Department of Sciences, University Roma Tre, Roma, Italy., De Vito P; Department of Biology, University Tor Vergata, Rome, Italy., Percario ZA; Department of Sciences, University Roma Tre, Roma, Italy., Leone S; Department of Sciences, University Roma Tre, Roma, Italy., Gnocchi D; Interdisciplinary Department of Medicine, University of Bari, School of Medicine, Bari, Italy., Rossi M; Department of Chemistry, Vassar College, Poughkeepsie, NY, United States., Caruso F; Department of Chemistry, Vassar College, Poughkeepsie, NY, United States., Scapin S; Department of Cellular and Developmental Biology, Sapienza University, Rome, Italy., Davis PJ; Department of Medicine, Albany Medical College, Albany, NY, United States.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, United States., Lin HY; Department of Medicine, Albany Medical College, Albany, NY, United States.; Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, United States.; Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Traditional Herbal Medicine Research Center of Taipei, Medical University Hospital, Taipei Medical University, Taipei, Taiwan.; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan., Affabris E; Department of Sciences, University Roma Tre, Roma, Italy., Pedersen JZ; Department of Biology, University Tor Vergata, Rome, Italy.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Sep 23; Vol. 13, pp. 961744. Date of Electronic Publication: 2022 Sep 23 (Print Publication: 2022).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Neoplasms*/metabolism , Triiodothyronine*/physiology, Adenosine Triphosphatases/metabolism ; Amino Acid Transport System A ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Glucose ; Humans ; Integrins/metabolism ; Mitogens ; Protein Kinase C/metabolism ; Thyroid Hormones/metabolism ; Thyroxine/metabolism
مستخلص: Thyroid hormones, T 3 (triiodothyronine) and T 4 (thyroxine), induce a variety of long-term effects on important physiological functions, ranging from development and growth to metabolism regulation, by interacting with specific nuclear or cytosolic receptors. Extranuclear or nongenomic effects of thyroid hormones are mediated by plasma membrane or cytoplasmic receptors, mainly by αvβ3 integrin, and are independent of protein synthesis. A wide variety of nongenomic effects have now been recognized to be elicited through the binding of thyroid hormones to this receptor, which is mainly involved in angiogenesis, as well as in cell cancer proliferation. Several signal transduction pathways are modulated by thyroid hormone binding to αvβ3 integrin: protein kinase C, protein kinase A, Src, or mitogen-activated kinases. Thyroid hormone-activated nongenomic effects are also involved in the regulation of Na + -dependent transport systems, such as glucose uptake, Na + /K + -ATPase, Na + /H + exchanger, and amino acid transport System A. Of note, the modulation of these transport systems is cell-type and developmental stage-dependent. In particular, dysregulation of Na + /K + -ATPase activity is involved in several pathological situations, from viral infection to cancer. Therefore, this transport system represents a promising pharmacological tool in these pathologies.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
(Copyright © 2022 Incerpi, Gionfra, De Luca, Candelotti, De Vito, Percario, Leone, Gnocchi, Rossi, Caruso, Scapin, Davis, Lin, Affabris and Pedersen.)
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فهرسة مساهمة: Keywords: 3,5-diiodothyronine; Na/K-ATPase; cancer; gibberellins; integrin αvβ3; signal transduction; thyroid hormone; virus infection
المشرفين على المادة: 0 (Amino Acid Transport System A)
0 (Integrins)
0 (Mitogens)
0 (Thyroid Hormones)
06LU7C9H1V (Triiodothyronine)
EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
EC 2.7.11.13 (Protein Kinase C)
EC 3.6.1.- (Adenosine Triphosphatases)
IY9XDZ35W2 (Glucose)
Q51BO43MG4 (Thyroxine)
تواريخ الأحداث: Date Created: 20221010 Date Completed: 20221011 Latest Revision: 20221013
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9540375
DOI: 10.3389/fendo.2022.961744
PMID: 36213288
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2022.961744