دورية أكاديمية
أعرض في EDS

ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.

التفاصيل البيبلوغرافية
العنوان: ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.
المؤلفون: Mathieu NM; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI., Nakagawa P; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.; Cardiovascular Center (P.N., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI., Grobe CC; Department of Pediatrics (C.C.G., J.L.S.), Medical College of Wisconsin, Milwaukee, WI., Reho JJ; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.; Comprehensive Rodent Metabolic Phenotyping Core (J.J.R., J.L.G.), Medical College of Wisconsin, Milwaukee, WI., Brozoski DT; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI., Lu KT; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI., Wackman KK; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI., Ritter ML; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI., Segar JL; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.; Cardiovascular Center (P.N., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.; Department of Pediatrics (C.C.G., J.L.S.), Medical College of Wisconsin, Milwaukee, WI., Grobe JL; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.; Cardiovascular Center (P.N., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.; Comprehensive Rodent Metabolic Phenotyping Core (J.J.R., J.L.G.), Medical College of Wisconsin, Milwaukee, WI.; Department of Biomedical Engineering (J.L.G.), Medical College of Wisconsin, Milwaukee, WI., Sigmund CD; Department of Physiology, Cardiovascular Center (N.M.M., P.N., J.J.R., D.T.B., K.-T.L., K.K.W., M.L.R., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.; Cardiovascular Center (P.N., J.L.S., J.L.G., C.D.S.), Medical College of Wisconsin, Milwaukee, WI.
المصدر: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2022 Nov; Vol. 79 (11), pp. 2480-2492. Date of Electronic Publication: 2022 Aug 23.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE
أسماء مطبوعة: Publication: : Hagerstown, MD : Lippincott, Williams & Wilkins
Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]-
مواضيع طبية MeSH: Desoxycorticosterone Acetate* , Hypertension*/genetics, Animals ; Mice ; Blood Pressure/physiology ; beta-Arrestin 2/genetics ; Mice, Inbred C57BL ; Sodium Chloride, Dietary/pharmacology ; Sodium Chloride/pharmacology ; Sodium ; beta-Arrestins ; Mice, Knockout ; Homeostasis ; Water ; Desoxycorticosterone
مستخلص: Background: GPCRs (G protein-coupled receptors) are implicated in blood pressure (BP) and fluid intake regulation. There is a developing concept that these effects are mediated by both canonical G protein signaling and noncanonical β-arrestin mediated signaling, but the contributions of each remain largely unexplored. Here, we hypothesized that β-arrestin contributes to fluid homeostasis and blood pressure (BP) regulation in deoxycorticosterone acetate (DOCA) salt hypertension, a prototypical model of salt-sensitive hypertension.
Methods: Global β-arrestin1 ( Arrb1 ) and β-arrestin2 ( Arrb2 ) knockout mice were employed to evaluate drinking behavior, and BP was evaluated in Arrb2 -knockout mice. Age- and sex-matched C57BL/6 mice served as controls. We measured intake of water and different sodium chloride solutions and BP employing a 2-bottle choice paradigm with and without DOCA.
Results: Without DOCA (baseline), Arrb2 -knockout mice exhibited a significant elevation in saline intake with no change in water intake. With DOCA treatment, Arrb2 -knockout mice exhibited a significant increase in both saline and water intake. Although Arrb2 -knockout mice exhibited hypernatremia at baseline conditions, we did not find significant changes in total body sodium stores or sodium palatability. In a separate cohort, BP was measured via telemetry in Arrb2 -knockout and C57BL/6 mice with and without DOCA. Arrb2 -knockout did not exhibit significant differences in BP before DOCA treatment when provided water alone, or when provided a choice of water and saline. However, Arrb2 -knockout exhibited an increased pressor response to DOCA-salt.
Conclusions: These findings suggest that in salt-sensitive hypertension, ARRB2, but not ARRB1 (β-arrestin 1), might counterbalance the canonical signaling of GPCRs.
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معلومات مُعتمدة: K01 HL153101 United States HL NHLBI NIH HHS; P01 HL084207 United States HL NHLBI NIH HHS; R01 HL134850 United States HL NHLBI NIH HHS; R35 HL144807 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: angiotensin; arrestin; blood pressure; homeostasis; hypertension
المشرفين على المادة: 6E0A168OB8 (Desoxycorticosterone Acetate)
0 (beta-Arrestin 2)
0 (Sodium Chloride, Dietary)
451W47IQ8X (Sodium Chloride)
9NEZ333N27 (Sodium)
0 (beta-Arrestins)
059QF0KO0R (Water)
40GP35YQ49 (Desoxycorticosterone)
0 (Arrb2 protein, mouse)
تواريخ الأحداث: Date Created: 20221010 Date Completed: 20221118 Latest Revision: 20231102
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9669141
DOI: 10.1161/HYPERTENSIONAHA.122.19863
PMID: 36215165
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4563
DOI:10.1161/HYPERTENSIONAHA.122.19863