دورية أكاديمية
Reinventing the Penumbra - the Emerging Clockwork of a Multi-modal Mechanistic Paradigm.
| العنوان: | Reinventing the Penumbra - the Emerging Clockwork of a Multi-modal Mechanistic Paradigm. |
|---|---|
| المؤلفون: | Walther J; Charité - Universitätsmedizin Berlin, Department of Neurology with Experimental Neurology, Charitéplatz 1, 10117, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany., Kirsch EM; Charité - Universitätsmedizin Berlin, Department of Neurology with Experimental Neurology, Charitéplatz 1, 10117, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany., Hellwig L; Charité - Universitätsmedizin Berlin, Department of Neurology with Experimental Neurology, Charitéplatz 1, 10117, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany., Schmerbeck SS; Charité - Universitätsmedizin Berlin, Department of Neurology with Experimental Neurology, Charitéplatz 1, 10117, Berlin, Germany.; Charité - Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany., Holloway PM; Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK., Buchan AM; Charité - Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany. alastair.buchan@medsci.ox.ac.uk.; Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK. alastair.buchan@medsci.ox.ac.uk., Mergenthaler P; Charité - Universitätsmedizin Berlin, Department of Neurology with Experimental Neurology, Charitéplatz 1, 10117, Berlin, Germany. philipp.mergenthaler@charite.de.; Charité - Universitätsmedizin Berlin, Center for Stroke Research Berlin, Charitéplatz 1, 10117, Berlin, Germany. philipp.mergenthaler@charite.de.; Charité - Universitätsmedizin Berlin, NeuroCure Clinical Research Center, Charitéplatz 1, 10117, Berlin, Germany. philipp.mergenthaler@charite.de.; Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK. philipp.mergenthaler@charite.de. |
| المصدر: | Translational stroke research [Transl Stroke Res] 2023 Oct; Vol. 14 (5), pp. 643-666. Date of Electronic Publication: 2022 Oct 11. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Springer |
| مواضيع طبية MeSH: | Stroke*/metabolism , Brain Ischemia*/metabolism, Humans ; Brain/metabolism ; Glucose ; Oxygen/metabolism |
| مستخلص: | The concept of the ischemic penumbra was originally defined as the area around a necrotic stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra is generally considered as time-sensitive hypoperfused brain tissue with decreased oxygen and glucose availability, salvageable tissue as treated by intervention, and the potential target for neuroprotection in focal stroke. The original concept entailed electrical failure and potassium release but one short of neuronal cell death and was based on experimental stroke models, later confirmed in clinical imaging studies. However, even though the basic mechanisms have translated well, conferring brain protection, and improving neurological outcome after stroke based on the pathophysiological mechanisms in the penumbra has yet to be achieved. Recent findings shape the modern understanding of the penumbra revealing a plethora of molecular and cellular pathophysiological mechanisms. We now propose a new model of the penumbra, one which we hope will lay the foundation for future translational success. We focus on the availability of glucose, the brain's central source of energy, and bioenergetic failure as core pathophysiological concepts. We discuss the relation of mitochondrial function in different cell types to bioenergetics and apoptotic cell death mechanisms, autophagy, and neuroinflammation, to glucose metabolism in what is a dynamic ischemic penumbra. (© 2022. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Apoptosis; Autophagy; Cell death; Glucose metabolism; Mitochondria; Neuroinflammation; Penumbra; Stroke |
| المشرفين على المادة: | IY9XDZ35W2 (Glucose) S88TT14065 (Oxygen) |
| تواريخ الأحداث: | Date Created: 20221011 Date Completed: 20230824 Latest Revision: 20230919 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10444697 |
| DOI: | 10.1007/s12975-022-01090-9 |
| PMID: | 36219377 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1868-601X |
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| DOI: | 10.1007/s12975-022-01090-9 |