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Lactobacillus paracasei IMC 502 ameliorates type 2 diabetes by mediating gut microbiota-SCFA-hormone/inflammation pathway in mice.

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العنوان: Lactobacillus paracasei IMC 502 ameliorates type 2 diabetes by mediating gut microbiota-SCFA-hormone/inflammation pathway in mice.
المؤلفون: Gu Y; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China.; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore., Chen H; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China., Li X; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China., Li D; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China., Sun Y; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China., Yang L; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China., Ma Y; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China., Chan ECY; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
المصدر: Journal of the science of food and agriculture [J Sci Food Agric] 2023 Apr; Vol. 103 (6), pp. 2949-2959. Date of Electronic Publication: 2022 Nov 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons
Original Publication: London, Society of Chemical Industry.
مواضيع طبية MeSH: Lacticaseibacillus paracasei* , Gastrointestinal Microbiome* , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Experimental* , Probiotics*/metabolism , Gastrointestinal Hormones*, Humans ; Mice ; Animals ; Aged ; Phosphatidylinositol 3-Kinases ; Inflammation
مستخلص: Background: Type 2 diabetes mellitus (T2DM) is a complex and prevalent metabolic disease that seriously threatens human health. Numerous studies have shown that probiotics as dietary supplements have the potential to prevent and treat T2DM. However, the ability of various strains to improve diabetes symptoms and corresponding mechanisms are different. Thus, mechanistic investigation is required to validate the pharmacology of each probiotic strain for T2DM treatment. Lactobacillus paracasei IMC 502 was originally isolated from Italian elderly human feces and its probiotic attributes have been demonstrated. Here, the antidiabetic pharmacodynamics of L. paracasei IMC 502 on T2DM mice was explored.
Results: Lactobacillus paracasei IMC 502 significantly decreased blood glucose, HbA1c and lipid levels, improved insulin resistance and glucose intolerance, regulated the mRNA/protein expression of key hepatic enzymes associated with gluconeogenesis, de novo lipogenesis and PI3K/Akt pathway, and repaired pancreatic and hepatic tissue damage. This probiotic conferred beneficial outcomes in the gut microbiome of diabetic mice, which induced transformation of short-chain fatty acids (SCFAs) and further enhanced the secretion of downstream hormones, and ultimately ameliorated the inflammatory response.
Conclusion: Lactobacillus paracasei IMC 502 prevents and alleviates T2DM by mediating the gut microbiota-SCFA-hormone/inflammation pathway. © 2022 Society of Chemical Industry.
(© 2022 Society of Chemical Industry.)
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معلومات مُعتمدة: SQ2020YFF0419518 National Science and Technology Major Project
فهرسة مساهمة: Keywords: L. paracasei IMC 502; gut microbiota; inflammation; insulin resistance; short-chain fatty acid; type 2 diabetes mellitus
المشرفين على المادة: EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
0 (Gastrointestinal Hormones)
تواريخ الأحداث: Date Created: 20221012 Date Completed: 20230314 Latest Revision: 20230314
رمز التحديث: 20240829
DOI: 10.1002/jsfa.12267
PMID: 36221226
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0010
DOI:10.1002/jsfa.12267