دورية أكاديمية
[Clinical Analysis of ABO-Incompatible Living-Donor Liver Transplantation in Children].
| العنوان: | [Clinical Analysis of ABO-Incompatible Living-Donor Liver Transplantation in Children]. |
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| المؤلفون: | Han HL; Department of Pediatric Hepatobiliary Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China., Dai XK; Department of Pediatric Hepatobiliary Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China., Li YC; Department of Pediatric Hepatobiliary Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China., Zhang MM; Department of Pediatric Hepatobiliary Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. |
| المصدر: | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition [Sichuan Da Xue Xue Bao Yi Xue Ban] 2022 Sep; Vol. 53 (5), pp. 777-781. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Sichuan da xue xue bao (yi xue ban) bian ji bu Country of Publication: China NLM ID: 101162609 Publication Model: Print Cited Medium: Print ISSN: 1672-173X (Print) Linking ISSN: 1672173X NLM ISO Abbreviation: Sichuan Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chengdu Shi : Sichuan da xue xue bao (yi xue ban) bian ji bu, 2003- |
| مواضيع طبية MeSH: | Liver Transplantation* , Living Donors*, ABO Blood-Group System ; Anticoagulants ; Blood Group Incompatibility ; Graft Rejection ; Graft Survival ; Humans ; Immunosuppressive Agents/therapeutic use ; Infant ; Postoperative Complications ; Retrospective Studies |
| مستخلص: | Objective: To evaluate the safety and clinical efficacy of ABO-incompatible living-donor liver transplantation (LDLT) in children. Methods: The clinical data of 62 children who underwent for the first time living donor liver transplantation in our hospital from April 2019 to July 2020 were retrospectively analyzed. According to the blood type matching of donor and recipient, the patients were divided into 3 groups, ABO-identical (ABO-Id, n =33), ABO-compatible (ABO-C, n =10) and ABO-incompatible (ABO-In, n =19), the median age of recipients in the three groups being 5 months. In the ABO-In group, 4 recipients whose condition was combined with liver failure and 2 recipients who had blood group antibody titers≥1∶32 received preoperative plasma exchange. All ABO-incompatible recipients had preoperative blood group antibody titers<1∶32. All recipients in the three groups underwent piggyback liver transplantation and received immunosuppressive and anticoagulation therapy. Postoperative follow-up was 5 to 20 months, the median being 12 months, measured until December 31, 2020 or until the date of death. Baseline clinical data, postoperative survival, and postoperative complications of recipients in the three groups were analyzed. Results: There were no significant differences in age, gender, underlying disease, operation history, Child Pugh score, donor age, graft to recipient weight ratio (GR/WR), cold ischemia time, warm ischemia time, duration of surgery, intraoperative blood loss and the use of immunosuppressants among the recipients in the three groups (all P >0.05). There was one death in the perioperative period and two deaths in the postoperative period in the ABO-Id group. There was one death in the postoperative period in the ABO-C group. There was one death in the perioperative period and one death in the postoperative period in the ABO-In group. There was no significant difference in the overall cumulative survival rate among the three groups ( P >0.05). There were no significant differences in the incidence of postoperative infection, acute rejection, biliary anastomotic stenosis and vascular complications among the three groups ( P >0.05). Conclusion: ABO-In LDLT is an effective and safe treatment option that can effectively expand the pool of live donors for liver transplantation and save the life of children with end-stage liver disease. (Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).) |
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| فهرسة مساهمة: | Keywords: ABO blood-group system; Blood group incompatibility; Children; Liver transplantation; Living donor; Prognosis |
| المشرفين على المادة: | 0 (ABO Blood-Group System) 0 (Anticoagulants) 0 (Immunosuppressive Agents) |
| تواريخ الأحداث: | Date Created: 20221012 Date Completed: 20221014 Latest Revision: 20230829 |
| رمز التحديث: | 20230830 |
| مُعرف محوري في PubMed: | PMC10408799 |
| DOI: | 10.12182/20220960201 |
| PMID: | 36224678 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1672-173X |
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| DOI: | 10.12182/20220960201 |