دورية أكاديمية
Clinician adherence to pharmacogenomics prescribing recommendations in clinical decision support alerts.
| العنوان: | Clinician adherence to pharmacogenomics prescribing recommendations in clinical decision support alerts. |
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| المؤلفون: | Nguyen JQ; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Crews KR; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Moore BT; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Kornegay NM; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Baker DK; Department of Information Services, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Hasan M; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Campbell PK; Department of Information Services, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Dean SM; Department of Information Services, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Pediatrics, St. Jude Children's Research Hospital, Memphis, Tennesse, USA., Relling MV; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Hoffman JM; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of the Office of Quality and Patient Safety, St. Jude Children's Research Hospital, Memphis, Tennesse, USA., Haidar CE; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. |
| المصدر: | Journal of the American Medical Informatics Association : JAMIA [J Am Med Inform Assoc] 2022 Dec 13; Vol. 30 (1), pp. 132-138. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9430800 Publication Model: Print Cited Medium: Internet ISSN: 1527-974X (Electronic) Linking ISSN: 10675027 NLM ISO Abbreviation: J Am Med Inform Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Oxford : Oxford University Press Original Publication: Philadelphia, PA : Hanley & Belfus, c1993- |
| مواضيع طبية MeSH: | Decision Support Systems, Clinical*, Humans ; Child ; Pharmacogenetics/methods ; Cytochrome P-450 CYP2D6/genetics ; Retrospective Studies ; Electronic Health Records |
| مستخلص: | Thoughtful integration of interruptive clinical decision support (CDS) alerts within the electronic health record is essential to guide clinicians on the application of pharmacogenomic results at point of care. St. Jude Children's Research Hospital implemented a preemptive pharmacogenomic testing program in 2011 in a multidisciplinary effort involving extensive education to clinicians about pharmacogenomic implications. We conducted a retrospective analysis of clinicians' adherence to 4783 pharmacogenomically guided CDS alerts that triggered for 12 genes and 60 drugs. Clinicians adhered to the therapeutic recommendations provided in 4392 alerts (92%). In our population of pediatric patients with catastrophic illnesses, the most frequently presented gene/drug CDS alerts were TPMT/NUDT15 and thiopurines (n = 3850), CYP2D6 and ondansetron (n = 667), CYP2D6 and oxycodone (n = 99), G6PD and G6PD high-risk medications (n = 51), and CYP2C19 and proton pump inhibitors (omeprazole and pantoprazole; n = 50). The high adherence rate was facilitated by our team approach to prescribing and our collaborative CDS design and delivery. (© The Author(s) 2022. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
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| معلومات مُعتمدة: | U24HG010135 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: clinical decision support; medication alert systems; pharmacogenetics; pharmacogenomics; precision medicine |
| المشرفين على المادة: | EC 1.14.14.1 (Cytochrome P-450 CYP2D6) |
| تواريخ الأحداث: | Date Created: 20221013 Date Completed: 20221215 Latest Revision: 20231014 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9748527 |
| DOI: | 10.1093/jamia/ocac187 |
| PMID: | 36228116 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1527-974X |
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| DOI: | 10.1093/jamia/ocac187 |