دورية أكاديمية
Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults.
| العنوان: | Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults. |
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| المؤلفون: | Sible IJ; Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA., Yew B; Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA., Jang JY; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Alitin JPM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Li Y; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Gaubert A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Nguyen A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Dutt S; Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA.; Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA., Blanken AE; San Francisco Veterans Affairs Health Care System, San Francisco, CA, 94121, USA.; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, 94158, USA., Ho JK; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA., Marshall AJ; Department of Psychology, University of Southern California, Los Angeles, CA, 90089, USA., Kapoor A; Department of Psychological Science, University of California, Irvine, Irvine, CA, 92697, USA., Shenasa F; Department of Psychological Science, University of California, Irvine, Irvine, CA, 92697, USA., Rodgers KE; Department of Pharmacology, Center for Innovation in Brain Science, The University of Arizona, Tucson, AZ, 85721, USA., Sturm VE; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Global Brain Health Institute, University of California, San Francisco, San Francisco, CA, 94158, USA., Head E; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA, 92697, USA., Martini A; Department of Pathology & Laboratory Medicine, University of California, Irvine, Irvine, CA, 92697, USA., Nation DA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 4201 Social and Behavioral Sciences Gateway, Irvine, CA, 92697-7085, USA. dnation@uci.edu.; Department of Psychological Science, University of California, Irvine, Irvine, CA, 92697, USA. dnation@uci.edu. |
| المصدر: | Scientific reports [Sci Rep] 2022 Oct 13; Vol. 12 (1), pp. 17197. Date of Electronic Publication: 2022 Oct 13. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Alzheimer Disease*, Aged ; Aged, 80 and over ; Amyloid beta-Peptides/cerebrospinal fluid ; Biomarkers ; Blood Pressure ; Cross-Sectional Studies ; Humans ; Middle Aged ; Peptide Fragments/cerebrospinal fluid ; Tomography, X-Ray Computed ; tau Proteins/cerebrospinal fluid |
| مستخلص: | Blood pressure variability is an emerging risk factor for Alzheimer's disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer's disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer's disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55-88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ (© 2022. The Author(s).) |
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| معلومات مُعتمدة: | R01 AG064228 United States AG NIA NIH HHS; R01 AG073244 United States AG NIA NIH HHS; R01 AG060049 United States AG NIA NIH HHS; P30 AG066519 United States AG NIA NIH HHS; R01 AG057204 United States AG NIA NIH HHS; P01 AG052350 United States AG NIA NIH HHS |
| المشرفين على المادة: | 0 (Amyloid beta-Peptides) 0 (Biomarkers) 0 (Peptide Fragments) 0 (tau Proteins) |
| تواريخ الأحداث: | Date Created: 20221013 Date Completed: 20221017 Latest Revision: 20230314 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9561652 |
| DOI: | 10.1038/s41598-022-20627-4 |
| PMID: | 36229634 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-022-20627-4 |