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Studies on the Phytochemical Profile of Ocimum basilicum var. minimum (L.) Alef. Essential Oil, Its Larvicidal Activity and In Silico Interaction with Acetylcholinesterase against Aedes aegypti (Diptera: Culicidae).

التفاصيل البيبلوغرافية
العنوان: Studies on the Phytochemical Profile of Ocimum basilicum var. minimum (L.) Alef. Essential Oil, Its Larvicidal Activity and In Silico Interaction with Acetylcholinesterase against Aedes aegypti (Diptera: Culicidae).
المؤلفون: Botelho AS; Faculty of Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, Augusto Corrêa Street, S/N, Guamá, Belém 66075-900, Pará, Brazil., Ferreira OO; Adolpho Ducke Laboratory-Botany Coordination, Emílio Goeldi Museum of Pará, Perimetral Avenue, 1901, Terra Firme, Belém 66077-830, Pará, Brazil., de Oliveira MS; Adolpho Ducke Laboratory-Botany Coordination, Emílio Goeldi Museum of Pará, Perimetral Avenue, 1901, Terra Firme, Belém 66077-830, Pará, Brazil., Cruz JN; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil., Chaves SHDR; Faculty of Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, Augusto Corrêa Street, S/N, Guamá, Belém 66075-900, Pará, Brazil., do Prado AF; Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa Street, S/N, Guamá, Belém 66075-900, Pará, Brazil., Nascimento LDD; Adolpho Ducke Laboratory-Botany Coordination, Emílio Goeldi Museum of Pará, Perimetral Avenue, 1901, Terra Firme, Belém 66077-830, Pará, Brazil., da Silva GA; Faculty of Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, Augusto Corrêa Street, S/N, Guamá, Belém 66075-900, Pará, Brazil., Amarante CBD; Chemical Analysis Laboratory-Coordination of Earth Sciences and Ecology, Emílio Goeldi Museum of Pará, Perimetral Avenue, 1901, Terra Firme, Belém 66077-830, Pará, Brazil., Andrade EHA; Faculty of Chemistry, Institute of Exact and Natural Sciences, Federal University of Pará, Augusto Corrêa Street, S/N, Guamá, Belém 66075-900, Pará, Brazil.; Adolpho Ducke Laboratory-Botany Coordination, Emílio Goeldi Museum of Pará, Perimetral Avenue, 1901, Terra Firme, Belém 66077-830, Pará, Brazil.; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Pará, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 22; Vol. 23 (19). Date of Electronic Publication: 2022 Sep 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Aedes* , Insecticides*/chemistry , Insecticides*/pharmacology , Ocimum basilicum* , Oils, Volatile*/chemistry , Oils, Volatile*/pharmacology , Zika Virus* , Zika Virus Infection*, Acetylcholinesterase ; Animals ; Eucalyptol ; Gas Chromatography-Mass Spectrometry ; Larva ; Limonene ; Molecular Docking Simulation ; Monoterpenes ; Phytochemicals/pharmacology
مستخلص: Aedes aegypti L. (Diptera: Culicidae) is an important transmitter of diseases in tropical countries and controlling the larvae of this mosquito helps to reduce cases of diseases such as dengue, zika and chikungunya. Thus, the present study aimed to evaluate the larvicidal potential of the essential oil (EO) of Ocimum basilicum var. minimum (L.) Alef. The EO was extracted by stem distillation and the chemical composition was characterized by gas chromatography coupled with mass spectrometry (GC/MS and GC-FID). The larvicidal activity of EO was evaluated against third instar Ae. aegypti following World Health Organization (WHO) standard protocol and the interaction of the major compounds with the acetylcholinesterase (AChE) was evaluated by molecular docking. The predominant class was oxygenated monoterpenes with a concentration of 81.69% and the major compounds were limonene (9.5%), 1,8-cineole (14.23%), linalool (24.51%) and methyl chavicol (37.41%). The O. basilicum var. minimum EO showed unprecedented activity against third instar Ae. aegypti larvae at a dose-dependent relationship with LC 50 of 69.91 (µg/mL) and LC 90 of 200.62 (µg/mL), and the major compounds were able to interact with AChE in the Molecular Docking assay, indicating an ecological alternative for mosquito larvae control.
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فهرسة مساهمة: Keywords: Ocimum; acetylcholinesterase; ecological; larvae; mosquito; natural products
المشرفين على المادة: 0 (Insecticides)
0 (Monoterpenes)
0 (Oils, Volatile)
0 (Phytochemicals)
9MC3I34447 (Limonene)
EC 3.1.1.7 (Acetylcholinesterase)
RV6J6604TK (Eucalyptol)
تواريخ الأحداث: Date Created: 20221014 Date Completed: 20221017 Latest Revision: 20221019
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9569541
DOI: 10.3390/ijms231911172
PMID: 36232474
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms231911172