دورية أكاديمية
أعرض في EDS

TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.

التفاصيل البيبلوغرافية
العنوان: TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis.
المؤلفون: Petkevicius K; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. kasparas.petkevicius@astrazeneca.com.; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. kasparas.petkevicius@astrazeneca.com., Palmgren H; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden., Glover MS; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Ahnmark A; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Andréasson AC; Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Madeyski-Bengtson K; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Kawana H; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.; Advanced Research & Development Programs for Medical Innovation (AMED-LEAP), Tokyo, Japan., Allman EL; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Kaper D; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden., Uhrbom M; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Andersson L; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Aasehaug L; Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Forsström J; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Wallin S; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ahlstedt I; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Leke R; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Karlsson D; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., González-King H; Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Löfgren L; Translational Science and Experimental Medicine, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Nilsson R; Translational Science and Experimental Medicine, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Pellegrini G; Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Kono N; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Aoki J; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.; Advanced Research & Development Programs for Medical Innovation (AMED-LEAP), Tokyo, Japan., Hess S; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Sienski G; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Pilon M; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden., Bohlooly-Y M; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Maresca M; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Peng XR; Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
المصدر: Nature communications [Nat Commun] 2022 Oct 14; Vol. 13 (1), pp. 6020. Date of Electronic Publication: 2022 Oct 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Non-alcoholic Fatty Liver Disease*/genetics , Non-alcoholic Fatty Liver Disease*/metabolism , Phosphatidylethanolamines*/metabolism, Animals ; Fatty Acids/metabolism ; Fatty Acids, Monounsaturated/metabolism ; Liver/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
مستخلص: The fatty acid composition of phosphatidylethanolamine (PE) determines cellular metabolism, oxidative stress, and inflammation. However, our understanding of how cells regulate PE composition is limited. Here, we identify a genetic locus on mouse chromosome 11, containing two poorly characterized genes Tlcd1 and Tlcd2, that strongly influences PE composition. We generated Tlcd1/2 double-knockout (DKO) mice and found that they have reduced levels of hepatic monounsaturated fatty acid (MUFA)-containing PE species. Mechanistically, TLCD1/2 proteins act cell intrinsically to promote the incorporation of MUFAs into PEs. Furthermore, TLCD1/2 interact with the mitochondria in an evolutionarily conserved manner and regulate mitochondrial PE composition. Lastly, we demonstrate the biological relevance of our findings in dietary models of metabolic disease, where Tlcd1/2 DKO mice display attenuated development of non-alcoholic steatohepatitis compared to controls. Overall, we identify TLCD1/2 proteins as key regulators of cellular PE composition, with our findings having broad implications in understanding and treating disease.
(© 2022. The Author(s).)
References: Genes Dev. 2021 May 1;35(9-10):635-657. (PMID: 33888557)
Nat Commun. 2021 Jan 21;12(1):497. (PMID: 33479216)
Sci Rep. 2022 Jan 20;12(1):1048. (PMID: 35058529)
Nature. 2011 Jan 27;469(7331):498-503. (PMID: 21270888)
Hepatology. 2005 Jun;41(6):1313-21. (PMID: 15915461)
Dig Dis Sci. 2016 May;61(5):1325-36. (PMID: 26626909)
Int J Exp Pathol. 1995 Apr;76(2):125-9. (PMID: 7786762)
Endocrinology. 1992 Jun;130(6):3356-64. (PMID: 1597147)
Elife. 2018 Dec 04;7:. (PMID: 30509349)
Nat Chem Biol. 2017 Jan;13(1):81-90. (PMID: 27842066)
Cell Metab. 2014 Jul 1;20(1):158-71. (PMID: 24856930)
Biochim Biophys Acta. 2012 Aug;1821(8):1078-88. (PMID: 22562055)
Nat Biotechnol. 2014 Oct;32(10):1019-25. (PMID: 25129690)
EMBO J. 2022 Dec 17;41(2):e106837. (PMID: 34873731)
Cell. 2019 May 2;177(4):881-895.e17. (PMID: 31051106)
Hepatology. 2013 Jan;57(1):81-92. (PMID: 22508243)
Nature. 2011 May 26;473(7348):528-31. (PMID: 21532591)
J Biol Chem. 1990 May 5;265(13):7248-56. (PMID: 2332429)
Nat Chem Biol. 2017 Jan;13(1):91-98. (PMID: 27842070)
Sci Rep. 2016 Jun 10;6:27688. (PMID: 27282822)
Cell Metab. 2006 May;3(5):321-31. (PMID: 16679290)
J Biol Chem. 2009 Aug 7;284(32):21185-91. (PMID: 19531470)
Eur J Lipid Sci Technol. 2015 Oct;117(10):1540-1549. (PMID: 26494980)
Nucleic Acids Res. 2021 Jan 8;49(D1):D1541-D1547. (PMID: 33174596)
J Lipid Res. 1968 Jan;9(1):65-7. (PMID: 5637431)
Cell Rep. 2018 Dec 18;25(12):3299-3314.e6. (PMID: 30566858)
Elife. 2015 Apr 21;4:. (PMID: 25898003)
Cell Metab. 2018 Oct 2;28(4):656-666.e1. (PMID: 30017358)
J Biol Chem. 2012 Dec 21;287(52):43961-71. (PMID: 23124206)
Nat Rev Mol Cell Biol. 2018 May;19(5):281-296. (PMID: 29410529)
Annu Rev Physiol. 2019 Feb 10;81:165-188. (PMID: 30379616)
J Cell Sci. 2011 Jan 1;124(Pt 1):5-8. (PMID: 21172818)
Trends Biochem Sci. 2002 Aug;27(8):381-3. (PMID: 12151215)
Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt A):110-21. (PMID: 26115647)
World J Gastroenterol. 2018 Jan 28;24(4):461-474. (PMID: 29398867)
Am J Respir Cell Mol Biol. 2014 Sep;51(3):436-45. (PMID: 24693920)
Nat Cell Biol. 2018 Dec;20(12):1370-1377. (PMID: 30397314)
J Biol Chem. 2003 Jun 13;278(24):21851-9. (PMID: 12668679)
iScience. 2021 Dec 04;25(1):103549. (PMID: 34977507)
J Comput Biol. 2017 Sep;24(9):906-916. (PMID: 28632398)
Front Immunol. 2022 Mar 31;13:867261. (PMID: 35432367)
Nucleic Acids Res. 2019 Jan 8;47(D1):D1225-D1228. (PMID: 30398659)
FASEB J. 2007 Aug;21(10):2622-32. (PMID: 17456783)
Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E745-E757. (PMID: 29989851)
Nat Biotechnol. 2020 Oct;38(10):1159-1163. (PMID: 32541957)
Int J Mol Sci. 2013 Oct 22;14(10):21167-88. (PMID: 24152446)
J Nutr. 2003 Nov;133(11):3386-91. (PMID: 14608048)
J Clin Invest. 2022 Jan 4;132(1):. (PMID: 34762602)
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1053-1060. (PMID: 30853650)
J Biol Chem. 2016 Jul 8;291(28):14457-67. (PMID: 27151215)
Cell Metab. 2013 Nov 5;18(5):685-97. (PMID: 24206663)
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):772-783. (PMID: 30010011)
Nat Methods. 2009 May;6(5):359-62. (PMID: 19377485)
J Clin Invest. 2018 Oct 1;128(10):4639-4653. (PMID: 30198910)
Nat Metab. 2020 Oct;2(10):1149-1162. (PMID: 32958938)
Cell. 2017 Oct 19;171(3):628-641.e26. (PMID: 29053969)
المشرفين على المادة: 0 (Fatty Acids)
0 (Fatty Acids, Monounsaturated)
0 (Phosphatidylethanolamines)
تواريخ الأحداث: Date Created: 20221014 Date Completed: 20221018 Latest Revision: 20221206
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9568529
DOI: 10.1038/s41467-022-33735-6
PMID: 36241646
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-33735-6