دورية أكاديمية
Toxicologic Insults to the Bovine Liver.
| العنوان: | Toxicologic Insults to the Bovine Liver. |
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| المؤلفون: | Newcomer BW; Veterinary Education, Research, & Outreach Program, Texas A&M University and West Texas A&M University, PO Box 60819, Canyon, TX 79016, USA. Electronic address: bnewcomer@tamu.edu. |
| المصدر: | The Veterinary clinics of North America. Food animal practice [Vet Clin North Am Food Anim Pract] 2022 Nov; Vol. 38 (3), pp. 421-432. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 8511905 Publication Model: Print Cited Medium: Internet ISSN: 1558-4240 (Electronic) Linking ISSN: 07490720 NLM ISO Abbreviation: Vet Clin North Am Food Anim Pract Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia : W.B. Saunders, c1985- |
| مواضيع طبية MeSH: | Cytochrome P-450 Enzyme System*/metabolism , Xenobiotics*, Animals ; Biotransformation ; Cattle ; Liver |
| مستخلص: | The liver is subject to toxic insult due to its role in the metabolism of exogenous substances and the direct filtration of blood from the portal circulation, which carries absorbed toxins from the gastrointestinal system. Metabolism of xenobiotics in the liver is facilitated by high concentrations of cytochrome P450 enzymes, which catalyze biotransformation of foreign substances; conjugation of toxin metabolites increases their solubility and enhances excretion. An understanding of the common hepatotoxins and the circumstances that lead to their exposure in cattle will aid the clinician in recognizing clinical syndromes and submitting appropriate diagnostic samples for confirmation of suspected diagnoses. Competing Interests: Disclosure The author has no conflicts of interest to disclose. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aflatoxin; Copper toxicity; Cyanobacteria; Hepatotoxicity; Pyrrolizidine alkaloids |
| المشرفين على المادة: | 0 (Xenobiotics) 9035-51-2 (Cytochrome P-450 Enzyme System) |
| تواريخ الأحداث: | Date Created: 20221015 Date Completed: 20221018 Latest Revision: 20221018 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.cvfa.2022.07.003 |
| PMID: | 36243463 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1558-4240 |
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| DOI: | 10.1016/j.cvfa.2022.07.003 |