دورية أكاديمية
Association between genetic polymorphisms in the melatonin receptor type 1 A gene and sleep bruxism.
| العنوان: | Association between genetic polymorphisms in the melatonin receptor type 1 A gene and sleep bruxism. |
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| المؤلفون: | Gaio DC; School of Health Sciences, Positivo University, Curitiba, Paraná, Brazil., Sebastiani AM; School of Health Sciences, Positivo University, Curitiba, Paraná, Brazil., do Nascimento Meger M; School of Health Sciences, Positivo University, Curitiba, Paraná, Brazil., Duarte J; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Polmann H; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Pauletto P; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Réus JC; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Souza JF; Department of Stomatology, School of Dentistry, Federal University of Paraná, Curitiba, Brazil., Souza AV; Graduate Program in Biotechnology Applied to Child and Adolescent Health - Pequeno Príncipe College, Pelé Research Institute, Curitiba, Paraná, Brazil., Machado-Souza C; Graduate Program in Biotechnology Applied to Child and Adolescent Health - Pequeno Príncipe College, Pelé Research Institute, Curitiba, Paraná, Brazil., Maia IS; Baía Sul Research Institute, Florianópolis, Santa Catarina, Brazil., Canto GL; Brazilian Center for Evidence-Based Research (COBE), Federal University of Santa Catarina, Florianópolis, Brazil; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Brancher JA; School of Health Sciences, Positivo University, Curitiba, Paraná, Brazil. Electronic address: brancher@up.edu.br. |
| المصدر: | Archives of oral biology [Arch Oral Biol] 2022 Dec; Vol. 144, pp. 105565. Date of Electronic Publication: 2022 Oct 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0116711 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1506 (Electronic) Linking ISSN: 00039969 NLM ISO Abbreviation: Arch Oral Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Pergamon Press Original Publication: Oxford, New York [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Sleep Bruxism*/genetics , Sleep Bruxism*/complications , Bruxism*/complications, Female ; Male ; Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Receptors, Melatonin/genetics ; Alleles ; Genotype ; Polymorphism, Single Nucleotide |
| مستخلص: | Objective: This study evaluated whether single nucleotide polymorphisms in the melatonin receptor type 1 A gene are associated with sleep bruxism in a Brazilian population. Design: Individuals with suspected sleep-related problems were evaluated using polysomnography, following the recommendations proposed by the American Academy of Sleep Medicine and the Research Diagnostic Criteria for Temporomandibular Disorders. Deoxyribonucleic acid (DNA) samples were collected, and three single nucleotide polymorphisms in the melatonin receptor type 1 A gene (rs13140012, rs6553010, and rs6847693) were selected and genotyped using real-time polymerase chain reaction (RT-PCR). Chi-square and odds ratio tests were used to analyze genotypes and alleles individually, while using the plink software for haplotypes. A confidence interval of 95% was considered, and statistical significance was set at p < 0.05. Results: This study included 48 individuals aged between 21 and 80 years, with 27 males and 21 females. From this sample, 17 individuals were diagnosed with sleep bruxism and 31 without bruxism. No associations were found between sleep bruxism and single nucleotide polymorphisms in either the genotypic, allelic, dominant, or recessive models (p > 0.05). Haplotype genetic analysis also did not reveal any association between single nucleotide polymorphisms and sleep bruxism (p > 0.05). Conclusion: The genetic polymorphisms rs6553010, rs13140012, and rs6847693 were not associated with sleep bruxism in the studied population. Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: None. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bruxism; Genetic polymorphisms; Genetics; Sleep bruxism |
| المشرفين على المادة: | 0 (Receptors, Melatonin) |
| تواريخ الأحداث: | Date Created: 20221016 Date Completed: 20221108 Latest Revision: 20221108 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.archoralbio.2022.105565 |
| PMID: | 36244129 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-1506 |
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| DOI: | 10.1016/j.archoralbio.2022.105565 |