دورية أكاديمية
Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats.
| العنوان: | Caffeine intoxication: Behavioral and electrocorticographic patterns in Wistar rats. |
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| المؤلفون: | Azevedo JEC; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil. Electronic address: julianne.azevedo@ics.ufpa.br., da Silva ALM; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil., Vieira LR; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil., Nascimento CP; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil., Pereira RG; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil., Rodrigues SF; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil., Hamoy AO; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil., Mello VJ; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil., Araújo DB; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil., Barbas LAL; Tropical Species Aquaculture Laboratory, Federal Institute of Education Science and Technology of Pará - Campus Castanhal, Castanhal, PA, Brazil., Lopez MEC; Molecular Pharmacology Laboratory. Federal University of Pará, UFPA, Belém, Pará, Brazil., Lopes DCF; Experimental Neuropathology Laboratory, Institute of Biological Sciences, Federal University of Pará, Belem, Pará, Brazil., Hamoy M; Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Pará, UFPA, Belém, Pará, Brazil. |
| المصدر: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Dec; Vol. 170, pp. 113452. Date of Electronic Publication: 2022 Oct 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Exeter : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Pentylenetetrazole*/toxicity , Phenytoin*/pharmacology, Rats ; Animals ; Rats, Wistar ; Caffeine/toxicity ; Anticonvulsants/toxicity ; Seizures/chemically induced ; Diazepam/adverse effects ; Phenobarbital |
| مستخلص: | Caffeine is a psychoactive substance used worldwide. The present study analyzes the seizure-related behavior and electrocorticographic (ECoG) patterns observed in rats following of a toxic dose of caffeine (150 mg/kg; intraperitoneal). Sixty-three rats were divided into three experiments: 1-Behavior's Description associated with caffeine-induced convulsion; 2- Comparison of the electrocorticographic patterns induced by caffeine and pentylenetetrazole, and 3- Assessment of the electrocorticographic response to antiepileptic drugs (diazepam, phenytoin, and phenobarbital). The behavioral analysis demonstrated tonic-clonic seizures with a loss of postural reflex and a latency of 365.8 s after the caffeine's administration. Caffeine-induced changes in the ECoG were consistent with the development of seizures with rapid evolution and burst potential consistent with the behavioral patterns observed during the caffeine-induced seizure. The ECoG of the brainwaves varied significantly between the seizures caused by caffeine and pentylenetetrazole. The predominant brain forces observed during the seizures were beta-band oscillations. The caffeine-induced seizures were resistant to attempted control with phenytoin and phenobarbital, but responded well to diazepam, which is consistent with a study of Pilocarpine, which showed that diazepam has anticonvulsant effects. These findings are important for the development of effective treatments for caffeine intoxication, in particular for individuals with a low seizure threshold. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Caffeine; Electrocorticography; Intoxication; Seizures; Toxicology |
| المشرفين على المادة: | WM5Z385K7T (Pentylenetetrazole) 6158TKW0C5 (Phenytoin) 3G6A5W338E (Caffeine) 0 (Anticonvulsants) Q3JTX2Q7TU (Diazepam) YQE403BP4D (Phenobarbital) |
| تواريخ الأحداث: | Date Created: 20221016 Date Completed: 20221206 Latest Revision: 20221206 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.fct.2022.113452 |
| PMID: | 36244459 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6351 |
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| DOI: | 10.1016/j.fct.2022.113452 |