دورية أكاديمية
Tic Disorders, Anti-Tic Medications, and Risk of Atopy.
| العنوان: | Tic Disorders, Anti-Tic Medications, and Risk of Atopy. |
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| المؤلفون: | Hakimi M; Renaissance School of Medicine at Stony Brook University Stony Brook New York USA.; Department of Pediatrics, Children's Hospital of Philadelphia Philadelphia Pennsylvania USA., Skinner S; Department of Neurology Renaissance School of Medicine at Stony Brook University Stony Brook New York USA., Maurer CW; Department of Neurology Renaissance School of Medicine at Stony Brook University Stony Brook New York USA. |
| المصدر: | Movement disorders clinical practice [Mov Disord Clin Pract] 2022 Jul 12; Vol. 9 (7), pp. 879-885. Date of Electronic Publication: 2022 Jul 12 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 101630279 Publication Model: eCollection Cited Medium: Internet ISSN: 2330-1619 (Electronic) Linking ISSN: 23301619 NLM ISO Abbreviation: Mov Disord Clin Pract Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : Wiley, [2014]- |
| مستخلص: | Objective: To clarify patterns of comorbid atopic disorders in children with tic disorders compared to controls, and to evaluate whether medications commonly used for treatment of tics and attention deficit hyperactivity disorder (ADHD) are associated with differing risks of atopy. Background: Inflammatory mechanisms are increasingly recognized as playing a role in a range of neuropsychiatric disorders. The association between tic disorders, ADHD, obsessive-compulsive disorder (OCD) and atopic disorders is uncertain. Methods: We performed a retrospective cohort study using the global electronic health records database TriNetX. Using odds ratios, we compared the risk of atopy in children with tic disorder (n = 4508), ADHD (n = 83,569), and/or OCD (n = 1555) to controls (n = 758 290). To analyze the risk of developing atopy with use of different medications commonly prescribed to treat tics and ADHD, we performed a separate analysis including children with tic disorder, ADHD, and/or OCD who had initiated treatment with one of these medications. Binary logistic regression controlling for age and sex was used to calculate odds ratios. Results: Children with tic disorder, ADHD, or OCD were more likely than controls to have comorbid atopy. Children who had taken clonidine, guanfacine, methylphenidate, or dexmethylphenidate were more likely to develop an atopic disorder than controls. Conclusions: Our study suggests a link between atopic disorders and tic disorders, ADHD, and OCD. Although the underlying mechanism for this association remains unclear, medication use may play a role. Competing Interests: M.H. was supported by the Renaissance School of Medicine at Stony Brook University Scholarly Concentrations Program Research Grant. The authors declare that there are no conflicts of interest relevant to this work. (© 2022 International Parkinson and Movement Disorder Society.) |
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| فهرسة مساهمة: | Keywords: ADHD; OCD; Tourette syndrome; atopy; tic disorders |
| تواريخ الأحداث: | Date Created: 20221017 Latest Revision: 20230713 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9547126 |
| DOI: | 10.1002/mdc3.13506 |
| PMID: | 36247912 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2330-1619 |
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| DOI: | 10.1002/mdc3.13506 |