دورية أكاديمية
أعرض في EDS

Neutrophils as drivers of vascular injury in sickle cell disease.

التفاصيل البيبلوغرافية
العنوان: Neutrophils as drivers of vascular injury in sickle cell disease.
المؤلفون: Torres LS; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA.; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA., Hidalgo A; Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.; Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
المصدر: Immunological reviews [Immunol Rev] 2023 Mar; Vol. 314 (1), pp. 302-312. Date of Electronic Publication: 2022 Oct 17.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Blackwell Country of Publication: England NLM ID: 7702118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-065X (Electronic) Linking ISSN: 01052896 NLM ISO Abbreviation: Immunol Rev Subsets: MEDLINE
أسماء مطبوعة: Publication: <2002-> : Oxford : Blackwell
Original Publication: Copenhagen, Munksgaard.
مواضيع طبية MeSH: Vascular System Injuries*/complications , Vascular System Injuries*/metabolism , Anemia, Sickle Cell*/complications , Vascular Diseases*/complications , Vascular Diseases*/pathology, Humans ; Mice ; Animals ; Neutrophils ; Erythrocytes/metabolism
مستخلص: While neutrophils are the main effectors of protective innate immune responses, they are also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood disorder in which red blood cells (RBCs) are constantly destroyed in the circulation which generates a highly inflammatory environment that culminates in vascular occlusions. Vaso-occlusion is the hallmark of SCD and a predictor of disease severity. Neutrophils initiate and propagate SCD-related vaso-occlusion through adhesive interactions with the activated and dysfunctional endothelium, sickle RBCs, and platelets, leading to acute and chronic complications that progress to irreversible organ damage and ultimately death. The use of SCD humanized mouse models, in combination with in vivo imaging techniques, has emerged as a fundamental tool to understand the dynamics of neutrophils under complex inflammatory contexts and their contribution to vascular injury in SCD. In this review, we discuss the various mechanisms by which circulating neutrophils sense and respond to the wide range of stimuli present in the blood of SCD patients and mice. We argue that the central role of neutrophils in SCD can be rationalized to develop targets for the management of clinical complications in SCD patients.
(© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: R01 AI165661 United States AI NIAID NIH HHS; R01 HL069438 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: cell adhesion; endothelium; hemolysis; inflammation; vaso-occlusion
تواريخ الأحداث: Date Created: 20221017 Date Completed: 20230329 Latest Revision: 20240302
رمز التحديث: 20240302
مُعرف محوري في PubMed: PMC10132504
DOI: 10.1111/imr.13146
PMID: 36251624
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-065X
DOI:10.1111/imr.13146