دورية أكاديمية

Canine transmissible venereal tumor - From general to molecular characteristics: A review.

التفاصيل البيبلوغرافية
العنوان: Canine transmissible venereal tumor - From general to molecular characteristics: A review.
المؤلفون: Faro TAS; Programa de Pós Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Belém, Pará, Brazil.; Laboratório de Citogenômica e Mutagênese Ambiental, SEAMB, Instituto Evandro Chagas Ananindeua, Belém, Pará, Brazil., de Oliveira EHC; Programa de Pós Graduação em Genética e Biologia Molecular, Universidade Federal do Pará, Belém, Pará, Brazil.; Laboratório de Citogenômica e Mutagênese Ambiental, SEAMB, Instituto Evandro Chagas Ananindeua, Belém, Pará, Brazil.
المصدر: Animal genetics [Anim Genet] 2023 Feb; Vol. 54 (1), pp. 82-89. Date of Electronic Publication: 2022 Oct 19.
نوع المنشور: Review; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8605704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2052 (Electronic) Linking ISSN: 02689146 NLM ISO Abbreviation: Anim Genet Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Oxford, England : Published by Blackwell Scientific Publications for the International Society for Animal Blood Group Research, c1986-
مواضيع طبية MeSH: Venereal Tumors, Veterinary*/genetics , Venereal Tumors, Veterinary*/pathology , Dog Diseases*/genetics , Dog Diseases*/pathology, Animals ; Dogs
مستخلص: Cancer is a group of complex diseases resulting from the accumulation of genetic and epigenetic changes affecting control and activity of several genes, especially those involved in cell differentiation and growth processes, leading to an abnormal proliferation. When the disease reaches an advanced stage, cancer can lead to metastasis in other organs. Interestingly, recent studies have shown that some types of cancer spread not only through the body, but also can be transmitted among individuals. Therefore, these cancers are known as transmissible tumors. Among the three types of transmissible tumors that occur in nature, the canine transmissible venereal tumor (CTVT) is known as the oldest cancer in the world, since it was originated from a single individual 11 000 years ago. The disease has a worldwide distribution, and its occurrence has been documented since 1810. The CTVT presents three types of cytomorphological classification: lymphocytoid type, mixed type, and plasmacytoid type, the latter being chemoresistant due to overexpression of the ABCB1 gene, and consequently increase of the P-glycoprotein. More knowledge about the epidemiology and evolution of CTVT may help to elucidate the pathway and form of the global spread of the disease.
(© 2022 Stichting International Foundation for Animal Genetics.)
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معلومات مُعتمدة: Coordination for the Improvement of Higher Education Personnel
فهرسة مساهمة: Keywords: canine transmissible venereal tumor; dogs; transmissible tumors
تواريخ الأحداث: Date Created: 20221019 Date Completed: 20230106 Latest Revision: 20230111
رمز التحديث: 20231215
DOI: 10.1111/age.13260
PMID: 36259378
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2052
DOI:10.1111/age.13260