دورية أكاديمية
أعرض في EDS

High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons.

التفاصيل البيبلوغرافية
العنوان: High-fidelity dendritic sodium spike generation in human layer 2/3 neocortical pyramidal neurons.
المؤلفون: Gooch HM; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Bluett T; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Perumal MB; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Vo HD; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Fletcher LN; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia., Papacostas J; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Jeffree RL; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Wood M; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Colditz MJ; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., McMillen J; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Tsahtsarlis T; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Amato D; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Campbell R; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Gillinder L; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; Mater Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia., Williams SR; Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: srw@uq.edu.au.
المصدر: Cell reports [Cell Rep] 2022 Oct 18; Vol. 41 (3), pp. 111500.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Neocortex*/physiology, Humans ; Rats ; Animals ; Patch-Clamp Techniques ; Action Potentials/physiology ; Rats, Wistar ; Pyramidal Cells/physiology ; Dendrites/physiology ; Sodium
مستخلص: Dendritic spikes function as cardinal components of rodent neocortical circuit computations. Recently, the biophysical properties of human pyramidal neurons (PNs) have been reported to be divergent, raising the question of whether dendritic spikes have homologous roles in the human neocortex. To directly address this, we made electrical recordings from the soma and apical dendrites of human and rat layer 2/3 PNs of the temporal cortex. In both species, dendritic excitatory input led to the initiation of sodium-channel-mediated dendritic spikes. Dendritic sodium spikes could be generated across a wide input range, exhibited a similar frequency range of activation, and forward-propagated with high-fidelity to implement stereotyped computations in human and rat PNs. However, the physical expansion and complexification of the apical dendritic trees of human PNs allowed the enriched expression of dendritic spike generation. The computational capacity of human PNs is therefore enhanced by the widespread implementation of a conserved dendritic integration mechanism.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: CP: Neuroscience; axon; dendrite; electrical excitability; evolution; neocortex; neuronal computations
المشرفين على المادة: 9NEZ333N27 (Sodium)
تواريخ الأحداث: Date Created: 20221019 Date Completed: 20221021 Latest Revision: 20221029
رمز التحديث: 20221213
DOI: 10.1016/j.celrep.2022.111500
PMID: 36260998
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2022.111500