دورية أكاديمية
أعرض في EDS

Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice.

التفاصيل البيبلوغرافية
العنوان: Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice.
المؤلفون: Wolstenholme JT; VCU-Alcohol Research Center and Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA., Saunders JM; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Smith M; VCU-Alcohol Research Center and Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA., Kang JD; Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Hylemon PB; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., González-Maeso J; Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA, USA., Fagan A; Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA., Zhao D; Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Sikaroodi M; Microbiome Analysis Center, George Mason University, Manassas, VA, USA., Herzog J; National Gnotobiotic Rodent Research Center, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Shamsaddini A; Microbiome Analysis Center, George Mason University, Manassas, VA, USA., Peña-Rodríguez M; University Center for Health Sciences, University of Guadalajara, Guadalajara, Jalisco, Mexico., Su L; Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Tai YL; Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Zheng J; Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Cheng PC; Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Sartor RB; National Gnotobiotic Rodent Research Center, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gillevet PM; Microbiome Analysis Center, George Mason University, Manassas, VA, USA., Zhou H; Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA., Bajaj JS; Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA. jasmohan.bajaj@vcuhealth.org.
المصدر: Nature communications [Nat Commun] 2022 Oct 19; Vol. 13 (1), pp. 6198. Date of Electronic Publication: 2022 Oct 19.
نوع المنشور: Randomized Controlled Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Fecal Microbiota Transplantation* , Alcoholism*/therapy, Humans ; Mice ; Animals ; Male ; Mice, Inbred C57BL ; Alcohol Drinking ; Ethanol
مستخلص: Alcohol use disorder is a major cause of morbidity, which requires newer treatment approaches. We previously showed in a randomized clinical trial that alcohol craving and consumption reduces after fecal transplantation. Here, to determine if this could be transmitted through microbial transfer, germ-free male C57BL/6 mice received stool or sterile supernatants collected from the trial participants pre-/post-fecal transplant. We found that mice colonized with post-fecal transplant stool but not supernatants reduced ethanol acceptance, intake and preference versus pre-fecal transplant colonized mice. Microbial taxa that were higher in post-fecal transplant humans were also associated with lower murine alcohol intake and preference. A majority of the differentially expressed genes (immune response, inflammation, oxidative stress response, and epithelial cell proliferation) occurred in the intestine rather than the liver and prefrontal cortex. These findings suggest a potential for therapeutically targeting gut microbiota and the microbial-intestinal interface to alter gut-liver-brain axis and reduce alcohol consumption in humans.
(© 2022. The Author(s).)
References: Microbiol Spectr. 2017 Aug;5(4):. (PMID: 28840806)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Hepatology. 2021 May;73(5):1688-1700. (PMID: 32750174)
J Neuroimmune Pharmacol. 2021 Oct 25;:. (PMID: 34694571)
Alcohol Clin Exp Res. 2018 Aug;42(8):1476-1485. (PMID: 29786878)
Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2149-2159. (PMID: 31937658)
Alcohol Clin Exp Res. 2017 Nov;41(11):1857-1865. (PMID: 28925102)
J Hepatol. 2014 May;60(5):940-7. (PMID: 24374295)
Chem Biodivers. 2010 May;7(5):1040-50. (PMID: 20491063)
Gut Microbes. 2021 Jan-Dec;13(1):1946367. (PMID: 34369304)
Pharmacol Biochem Behav. 2019 Sep;184:172740. (PMID: 31326461)
Cell Rep. 2020 Oct 13;33(2):108238. (PMID: 33053357)
Microbiome. 2017 Oct 17;5(1):141. (PMID: 29041989)
World J Gastroenterol. 2010 Mar 21;16(11):1321-9. (PMID: 20238398)
Hepatology. 2020 Feb;71(2):611-626. (PMID: 31220352)
PLoS One. 2013;8(4):e60042. (PMID: 23565181)
Nat Commun. 2020 May 18;11(1):2471. (PMID: 32424203)
Sci Rep. 2016 Jun 13;6:27923. (PMID: 27295340)
Alcohol Clin Exp Res. 1983 Spring;7(2):140-3. (PMID: 6346915)
Nature. 2014 Sep 4;513(7516):59-64. (PMID: 25079328)
J Hepatol. 2017 Apr;66(4):806-815. (PMID: 27890791)
Gastroenterology. 2014 May;146(6):1513-24. (PMID: 24440671)
Liver Res. 2019 Mar;3(1):19-24. (PMID: 31360579)
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4485-93. (PMID: 25288760)
Am J Prev Med. 2020 Oct;59(4):469-480. (PMID: 32863077)
Alcohol Alcohol. 2017 Jul 01;52(4):414-424. (PMID: 28482064)
Bioinformatics. 2014 Feb 15;30(4):523-30. (PMID: 24336805)
Alcohol. 2019 Feb;74:105-111. (PMID: 30031625)
Behav Brain Res. 2020 Mar 16;382:112500. (PMID: 31978491)
J Endocr Soc. 2020 Feb 20;4(2):bvz039. (PMID: 32099951)
Alcohol Clin Exp Res. 2011 Nov;35(11):1938-47. (PMID: 21631540)
J Hepatol. 2021 Jul;75 Suppl 1:S67-S81. (PMID: 34039493)
PLoS One. 2011;6(6):e21100. (PMID: 21698166)
JAMA Netw Open. 2020 Sep 1;3(9):e2022942. (PMID: 32990735)
Hepatology. 2020 Jan;71(1):306-333. (PMID: 31314133)
J Hepatol. 2016 Sep;65(3):618-30. (PMID: 27155530)
PLoS One. 2011;6(7):e21800. (PMID: 21789182)
Mayo Clin Proc. 2021 Apr;96(4):1006-1016. (PMID: 33714602)
Alcohol Clin Exp Res. 2018 Apr;42(4):660-667. (PMID: 29417604)
Hepatology. 2019 Jun;69(6):2683-2695. (PMID: 30468515)
Gut. 2016 May;65(5):830-9. (PMID: 26642859)
Nat Rev Gastroenterol Hepatol. 2019 Apr;16(4):235-246. (PMID: 30643227)
Nat Commun. 2021 May 28;12(1):3105. (PMID: 34050144)
PLoS One. 2020 Jun 18;15(6):e0234860. (PMID: 32555605)
Gastroenterology. 2005 Apr;128(4):891-906. (PMID: 15825073)
PLoS One. 2013;8(1):e53028. (PMID: 23326376)
Hepatol Commun. 2017 Feb 27;1(1):61-70. (PMID: 29404434)
Genome Biol. 2011 Jun 24;12(6):R60. (PMID: 21702898)
Gut Microbes. 2014 May-Jun;5(3):333-9. (PMID: 24642476)
J Neurophysiol. 2010 Jan;103(1):297-321. (PMID: 19889849)
Clin Transl Gastroenterol. 2016 Aug 25;7(8):e187. (PMID: 27560928)
Gastroenterol Hepatol Bed Bench. 2019;12(Suppl1):S80-S86. (PMID: 32099606)
Neuropsychopharmacology. 2018 Dec;43(13):2521-2531. (PMID: 30188517)
معلومات مُعتمدة: P40 OD010995 United States OD NIH HHS; P30 DK034987 United States DK NIDDK NIH HHS; I01 CX001076 United States CX CSRD VA; P50 AA022537 United States AA NIAAA NIH HHS; R01 MH084894 United States MH NIMH NIH HHS; F30 MH116550 United States MH NIMH NIH HHS; I01 BX004033 United States BX BLRD VA; R21 TR003095 United States TR NCATS NIH HHS; P01 DK094779 United States DK NIDDK NIH HHS; R21 AA026629 United States AA NIAAA NIH HHS; IK6 BX004477 United States BX BLRD VA; R01 MH111940 United States MH NIMH NIH HHS; R01 AA026347 United States AA NIAAA NIH HHS; R01 DK104893 United States DK NIDDK NIH HHS; R01 DK057543 United States DK NIDDK NIH HHS
المشرفين على المادة: 3K9958V90M (Ethanol)
تواريخ الأحداث: Date Created: 20221019 Date Completed: 20221021 Latest Revision: 20240520
رمز التحديث: 20240520
مُعرف محوري في PubMed: PMC9581985
DOI: 10.1038/s41467-022-34054-6
PMID: 36261423
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-34054-6