دورية أكاديمية
أعرض في EDS

Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.

التفاصيل البيبلوغرافية
العنوان: Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
المؤلفون: Moitinho-Silva L; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany., Degenhardt F; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Rodriguez E; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany., Emmert H; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany., Juzenas S; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.; Institute of Biotechnology, Life Science Centre, Vilnius University, Vilnius, Lithuania., Möbus L; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany., Uellendahl-Werth F; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Sander N; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany., Baurecht H; Department for Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Tittmann L; Biobank PopGen and Institute of Epidemiology, Kiel University, Kiel, Germany., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Gieger C; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Ellinghaus D; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Bang C; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany. a.franke@mucosa.de., Weidinger S; Department of Dermatology and Allergy, University Hospital Schleswig-Holstein, Kiel, Germany. sweidinger@dermatology.uni-kiel.de., Rühlemann MC; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
المصدر: Nature communications [Nat Commun] 2022 Oct 19; Vol. 13 (1), pp. 6204. Date of Electronic Publication: 2022 Oct 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Microbiota*/genetics , Gastrointestinal Microbiome*/genetics, Humans ; Genome-Wide Association Study ; Skin ; Immunity, Innate/genetics
مستخلص: Despite the increasing knowledge about factors shaping the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize host genes that influence the gut microbiota. Here, we investigated the effect of genetics on skin microbiota across three different skin microenvironments through meta-analyses of genome-wide association studies (GWAS) of two population-based German cohorts. We identified 23 genome-wide significant loci harboring 30 candidate genes involved in innate immune signaling, environmental sensing, cell differentiation, proliferation and fibroblast activity. However, no locus passed the strict threshold for study-wide significance (P < 6.3 × 10 -10 for 80 features included in the analysis). Mendelian randomization (MR) analysis indicated the influence of staphylococci on eczema/dermatitis and suggested modulating effects of the microbiota on other skin diseases. Finally, transcriptional profiles of keratinocytes significantly changed after in vitro co-culturing with Staphylococcus epidermidis, chosen as a representative of skin commensals. Seven candidate genes from the GWAS were found overlapping with differential expression in the co-culturing experiments, warranting further research of the skin commensal and host genetic makeup interaction.
(© 2022. The Author(s).)
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تواريخ الأحداث: Date Created: 20221019 Date Completed: 20221021 Latest Revision: 20221222
رمز التحديث: 20221223
مُعرف محوري في PubMed: PMC9582029
DOI: 10.1038/s41467-022-33906-5
PMID: 36261456
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-33906-5