دورية أكاديمية
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Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats.

التفاصيل البيبلوغرافية
العنوان: Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats.
المؤلفون: Joshua PE; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Federal Republic of Nigeria., Yahaya J; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Federal Republic of Nigeria.; Department of Human Physiology, Faculty of Basic Medical Sciences, Colleges of Health Sciences, Kogi State University, P.M.B. 1008, Anyigba, Kogi State, Federal Republic of Nigeria., Ekpo DE; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Federal Republic of Nigeria. ekpodaniele@gmail.com., Ogidigo JO; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Federal Republic of Nigeria.; Bioresources Development Centre, National Biotechnology Development Agency (NABDA), Federal Capital Territory, Abuja, Federal Republic of Nigeria., Odiba AS; Department of Molecular Genetics and Biotechnology, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Federal Republic of Nigeria.; Department of Biochemistry, College of Life Science and Technology, Guangxi University, Nanning, 530007, People's Republic of China.; National Engineering Research Centre for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning, 530007, People's Republic of China., Asomadu RO; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Federal Republic of Nigeria., Oka SA; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Federal Republic of Nigeria.; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Colleges of Health Sciences, Kogi State University, P.M.B. 1008, Anyigba, Kogi State, Federal Republic of Nigeria., Adeniyi OS; Department of Physiology, Faculty of Basic and Allied Medical Sciences, Benue State University, Makurdi, Benue State, Federal Republic of Nigeria.
المصدر: BMC immunology [BMC Immunol] 2022 Oct 19; Vol. 23 (1), pp. 50. Date of Electronic Publication: 2022 Oct 19.
نوع المنشور: Journal Article; Randomized Controlled Trial, Veterinary
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100966980 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2172 (Electronic) Linking ISSN: 14712172 NLM ISO Abbreviation: BMC Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: Catechin* , Datura stramonium* , Saponins*, Animals ; Rats ; Antioxidants/pharmacology ; Catalase ; Chlorogenic Acid ; Cyclophosphamide ; Gallic Acid/pharmacology ; Glutathione Peroxidase ; Immunoglobulin A ; Immunoglobulin G ; Immunosuppression Therapy ; Levamisole ; Limonene ; Lipoproteins, HDL ; Luteolin ; Plant Extracts/pharmacology ; Quercetin ; Quinine ; Rats, Wistar ; Seeds ; Superoxide Dismutase ; Tannins ; Vanillic Acid ; Vitamins ; Water
مستخلص: Background: Datura stramonium L. (Solanaceae) is used traditionally in west Africa to treat asthma, epilepsy, rheumatoid arthritis, filariasis microbial infections and conjunctivitis. This study investigated the immunomodulatory effects of aqueous seed extract of D. stramonium L. (ASEDS) on Wistar rats.
Methods: Thirty Wistar albino rats (180-200 g) were randomized into 6 groups (n = 5). Group 1 received distilled water only. Rats in groups 2-6 were pretreated with 10 mg/kg body weight (b.w.) Cyclophosphamide orally for 27-days to induce immunosuppression. Thereafter, they received treatment orally for 28 days as follows: Group 2 (distilled water), group 3 (5 mg/kg b.w. Levamisole), groups 4-6 (60, 90 and 120 mg/kg b.w. ASEDS, respectively). HPLC was used to determine major compounds in ASEDS. The effects of ASEDS on immune cells, immunoglobulins A, G and M levels, lipoproteins, and antioxidant status of rats were evaluated.
Results: ASEDS indicated high content of Acutumine, Quinine, Catechin, Chlorogenic acid, Gallic acid, Quercetin, Vanillic acid, Luteolin, Formosanin C, Saponin, Cyanidin, Tannic acid, 3-Carene, Limonene and α-terpineol. Cyclophosphamide triggered significant (p < 0.05) reduction in total leucocyte count and differentials, IgA, IgG, high-density lipoproteins (HDL), catalase, superoxide dismutase, glutathione peroxidase, vitamins A, C and E levels of untreated rats. Administration of ASEDS led to significant (p < 0.05) improvement in immune cell counts, immunoglobulin synthesis, high-density lipoprotein concentration, and antioxidant status of rats in the treated groups.
Conclusions: The results obtained from the study showed the immunomodulatory activity of ASEDS, thereby indicating its potential in immunostimulatory drug discovery.
(© 2022. The Author(s).)
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فهرسة مساهمة: Keywords: Cyclophosphamide; Datura stramonium L.; Immune system; Immunoglobulins; Immunosuppression; Medicinal plants; Wistar rats
المشرفين على المادة: 0 (Antioxidants)
EC 1.11.1.6 (Catalase)
8R1V1STN48 (Catechin)
318ADP12RI (Chlorogenic Acid)
8N3DW7272P (Cyclophosphamide)
632XD903SP (Gallic Acid)
EC 1.11.1.9 (Glutathione Peroxidase)
0 (Immunoglobulin A)
0 (Immunoglobulin G)
2880D3468G (Levamisole)
9MC3I34447 (Limonene)
0 (Lipoproteins, HDL)
KUX1ZNC9J2 (Luteolin)
0 (Plant Extracts)
9IKM0I5T1E (Quercetin)
A7V27PHC7A (Quinine)
0 (Saponins)
EC 1.15.1.1 (Superoxide Dismutase)
0 (Tannins)
GM8Q3JM2Y8 (Vanillic Acid)
0 (Vitamins)
059QF0KO0R (Water)
تواريخ الأحداث: Date Created: 20221019 Date Completed: 20221026 Latest Revision: 20221027
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9583546
DOI: 10.1186/s12865-022-00519-y
PMID: 36261807
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2172
DOI:10.1186/s12865-022-00519-y