دورية أكاديمية
أعرض في EDS

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine.

التفاصيل البيبلوغرافية
العنوان: A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine.
المؤلفون: Corrêa HL; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil. hugo.efucb@gmail.com., Raab ATO; Faculty of Medicine, Catholic University of Brasilia, Brasília, Distrito Federal, Brazil., Araújo TM; Faculty of Bio-Medicine, Catholic University of Brasilia, Brasília, Distrito Federal, Brazil., Deus LA; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil., Reis AL; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil., Honorato FS; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil., Rodrigues-Silva PL; Embrapa Genetic Resources and Biotechnology, Brasilia, Distrito Federal, 70000-000, Brazil., Neves RVP; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil., Brunetta HS; Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil., Mori MADS; Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.; Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster, University of Campinas, Campinas, Brazil., Franco OL; Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, DF, Brazil.; S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil., Rosa TDS; Graduate Program of Physical Education, Catholic University of Brasilia (UCB), EPTC, QS07, LT1 S/N, Bloco G Sala 119, Águas Claras, Taguatinga, Brasília, Distrito Federal, CEP 72030-170, Brazil. thiagoacsdkp@yahoo.com.br.
المصدر: Scientific reports [Sci Rep] 2022 Oct 20; Vol. 12 (1), pp. 17587. Date of Electronic Publication: 2022 Oct 20.
نوع المنشور: Meta-Analysis; Systematic Review; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Resistance Training*/methods, Humans ; Adult ; Middle Aged ; Aged ; Exercise/physiology ; Muscle, Skeletal
مستخلص: Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise increases Klotho levels, regardless of the condition or intervention, shedding some light on this anti-aging protein as an emergent and promising exerkine. Development of a systematic review and meta-analysis in order to verify the role of different exercise training protocols on the levels of circulating soluble Klotho (S-Klotho) protein. A systematic search of the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE through PubMed, EMBASE, CINAHL, CT.gov, and PEDro. Randomized and quasi-randomized controlled trials that investigated effects of exercise training on S-Klotho levels. We included 12 reports in the analysis, comprising 621 participants with age ranging from 30 to 65 years old. Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge' g [95%CI] 1.3 [0.69-1.90]; P < 0.0001). Moreover, exercise training increases S-Klotho values regardless of the health condition of the individual or the exercise intervention, with the exception of combined aerobic + resistance training. Furthermore, protocol duration and volume seem to influence S-Klotho concentration, since the effect of the meta-analysis changes when subgrouping these variables. Altogether, circulating S-Klotho protein is altered after chronic exercise training and it might be considered an exerkine. However, this effect may be influenced by different training configurations, including protocol duration, volume, and intensity.
(© 2022. The Author(s).)
References: Br J Sports Med. 2021 Dec;55(23):1319-1321. (PMID: 34215643)
Biogerontology. 2013 Dec;14(6):729-39. (PMID: 24030242)
J Biol Chem. 2006 Mar 10;281(10):6120-3. (PMID: 16436388)
Eur J Sport Sci. 2018 Mar;18(2):226-234. (PMID: 29220206)
Physiol Behav. 2021 Jul 1;236:113413. (PMID: 33811909)
Free Radic Biol Med. 2013 Dec;65:380-401. (PMID: 23851032)
Acta Physiol (Oxf). 2019 Feb;225(2):e13190. (PMID: 30251773)
J Physiol. 2021 Feb;599(3):791-802. (PMID: 31749163)
Nephrourol Mon. 2016 Jan 09;8(1):e30245. (PMID: 26981496)
J Gerontol A Biol Sci Med Sci. 2015 Sep;70(9):1156-62. (PMID: 25748032)
Int J Mol Sci. 2017 Jun 13;18(6):. (PMID: 28608819)
Acta Med Indones. 2017 Apr;49(2):158-165. (PMID: 28790231)
Aging (Albany NY). 2020 Jan 20;12(3):2698-2710. (PMID: 31958773)
Kidney Int. 2008 Sep;74(6):732-9. (PMID: 18547997)
J Physiol. 2012 Jan 15;590(2):351-62. (PMID: 22106173)
Rejuvenation Res. 2012 Jun;15(3):295-301. (PMID: 22530731)
Sports Med. 2019 Apr;49(4):509-523. (PMID: 30778851)
Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H348-55. (PMID: 24322608)
Nitric Oxide. 2020 Sep 1;102:42-51. (PMID: 32565116)
Nephrol Dial Transplant. 2012 Dec;27 Suppl 4:iv6-10. (PMID: 23258814)
Clin Exp Nephrol. 2019 May;23(5):621-628. (PMID: 30729347)
Mol Cell Biochem. 2009 Dec;332(1-2):225-31. (PMID: 19588229)
J Appl Physiol (1985). 2012 Mar;112(5):806-15. (PMID: 22174394)
Skelet Muscle. 2018 Jul 4;8(1):20. (PMID: 29973273)
Sports Med. 2009;39(3):179-206. (PMID: 19290675)
Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):238-251. (PMID: 28982613)
Hum Exp Toxicol. 2013 Feb;32(2):120-52. (PMID: 23060412)
Diabetes. 2015 Apr;64(4):1444-58. (PMID: 25377875)
Br J Sports Med. 2011 Apr;45(4):304-9. (PMID: 21357577)
Nat Rev Endocrinol. 2016 Sep;12(9):504-17. (PMID: 27230949)
Br J Sports Med. 2016 Nov;50(22):1356-1357. (PMID: 27288514)
Exp Mol Med. 2020 Feb;52(2):266-280. (PMID: 32054986)
Cells. 2019 Nov 04;8(11):. (PMID: 31689891)
Rejuvenation Res. 2019 Dec;22(6):478-483. (PMID: 30672377)
BMJ. 2015 Jan 02;350:g7647. (PMID: 25555855)
Nat Rev Drug Discov. 2016 Oct;15(10):719-29. (PMID: 27616294)
Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L566-75. (PMID: 25063799)
Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F557-F564. (PMID: 31928223)
J Appl Physiol (1985). 2021 Feb 1;130(2):508-516. (PMID: 33242299)
Nephrology (Carlton). 2008 Apr;13(2):147-52. (PMID: 18275503)
Nat Rev Nephrol. 2019 Jan;15(1):27-44. (PMID: 30455427)
Diabetes Res Clin Pract. 2016 Mar;113:208-10. (PMID: 26806457)
Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):. (PMID: 28490541)
J Biol Chem. 2005 Nov 11;280(45):38029-34. (PMID: 16186101)
J Strength Cond Res. 2016 Jan;30(1):251-8. (PMID: 26691414)
Med Sci Sports Exerc. 2021 Feb 1;53(2):249-257. (PMID: 32826635)
Free Radic Biol Med. 2016 Sep;98:78-89. (PMID: 26898145)
J Physiol. 2019 Sep;597(17):4601-4613. (PMID: 31294822)
Nat Cell Biol. 2011 Mar;13(3):254-62. (PMID: 21336305)
Eur J Appl Physiol. 2012 Apr;112(4):1215-20. (PMID: 21769735)
Aging (Albany NY). 2019 Aug 7;11(15):5319-5333. (PMID: 31390595)
Biol Chem. 2008 Mar;389(3):233-41. (PMID: 18177265)
Aging (Albany NY). 2019 Dec 30;11(24):12793-12809. (PMID: 31895692)
Respiration. 2017;93(5):301-310. (PMID: 28329753)
Curr Aging Sci. 2018;11(2):100-107. (PMID: 29962352)
Circulation. 2001 Sep 18;104(12):1350-7. (PMID: 11560849)
Front Physiol. 2014 Jun 17;5:189. (PMID: 24987372)
Toxins (Basel). 2020 Apr 04;12(4):. (PMID: 32260373)
Br J Sports Med. 2015 Sep;49(18):1189-96. (PMID: 25872521)
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142. (PMID: 31643080)
Int J Sports Med. 2021 Sep;42(10):889-895. (PMID: 33684951)
Cochrane Database Syst Rev. 2011 Nov 09;(11):MR000027. (PMID: 22071866)
Bone. 2017 Jul;100:41-49. (PMID: 28115282)
Int Rev Neurobiol. 2019;147:361-395. (PMID: 31607361)
Nat Rev Nephrol. 2012 Jun 05;8(7):423-9. (PMID: 22664739)
Lab Invest. 2016 Feb;96(2):197-205. (PMID: 26237271)
Eur J Appl Physiol. 2018 Nov;118(11):2319-2329. (PMID: 30094648)
Nat Commun. 2018 Nov 19;9(1):4859. (PMID: 30451844)
Kidney Int. 2010 Dec;78(12):1240-51. (PMID: 20861825)
Free Radic Biol Med. 2016 Sep;98:113-122. (PMID: 26916558)
Maturitas. 2019 May;123:25-31. (PMID: 31027673)
Exp Physiol. 2020 Jan;105(1):132-147. (PMID: 31724771)
Exp Gerontol. 2017 Oct 15;97:17-21. (PMID: 28729213)
Biochem Biophys Res Commun. 2018 Oct 28;505(2):448-452. (PMID: 30269819)
Chem Biol Interact. 2014 Dec 5;224:164-75. (PMID: 25452175)
Br J Sports Med. 2017 Mar;51(6):549-550. (PMID: 27251899)
Exp Physiol. 2013 Feb;98(2):359-71. (PMID: 22941979)
J Clin Endocrinol Metab. 2015 Oct;100(10):E1308-18. (PMID: 26280509)
Nature. 1997 Nov 6;390(6655):45-51. (PMID: 9363890)
Ann N Y Acad Sci. 2017 Aug;1402(1):5-9. (PMID: 28437576)
Oncotarget. 2017 Feb 28;8(9):15663-15676. (PMID: 28152512)
Science. 2005 Sep 16;309(5742):1829-33. (PMID: 16123266)
Iran J Kidney Dis. 2020 May;14(3):212-218. (PMID: 32361698)
Eur J Sport Sci. 2019 Aug;19(7):994-1003. (PMID: 30732555)
J Sports Sci. 2019 Oct;37(19):2175-2183. (PMID: 31164040)
تواريخ الأحداث: Date Created: 20221020 Date Completed: 20221024 Latest Revision: 20230112
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9585050
DOI: 10.1038/s41598-022-22123-1
PMID: 36266389
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-022-22123-1