دورية أكاديمية
Identification of environmental factors that promote intestinal inflammation.
| العنوان: | Identification of environmental factors that promote intestinal inflammation. |
|---|---|
| المؤلفون: | Sanmarco LM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Chao CC; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wang YC; Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan., Kenison JE; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Li Z; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rone JM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rejano-Gordillo CM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Polonio CM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Gutierrez-Vazquez C; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Piester G; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Plasencia A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Li L; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Giovannoni F; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lee HG; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Faust Akl C; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wheeler MA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA., Mascanfroni I; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Jaronen M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Alsuwailm M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Hewson P; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Yeste A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Andersen BM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Franks DG; Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA, USA., Huang CJ; Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan., Ekwudo M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Tjon EC; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rothhammer V; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Takenaka M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., de Lima KA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Linnerbauer M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Guo L; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Covacu R; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Queva H; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Fonseca-Castro PH; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Bladi MA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Cox LM; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Hodgetts KJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Hahn ME; Biology Department, Woods Hole Oceanographic Institution, Woods Hole, MA, USA., Mildner A; Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany., Korzenik J; Department of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Hauser R; Harvard T. H. Chan School of Public Health, Boston, MA, USA., Snapper SB; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Quintana FJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. fquintana@rics.bwh.harvard.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, USA. fquintana@rics.bwh.harvard.edu. |
| المصدر: | Nature [Nature] 2022 Nov; Vol. 611 (7937), pp. 801-809. Date of Electronic Publication: 2022 Oct 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basingstoke : Nature Publishing Group Original Publication: London, Macmillan Journals ltd. |
| مواضيع طبية MeSH: | Inflammation*/chemically induced , Inflammation*/etiology , Inflammation*/immunology , Inflammation*/pathology , Inflammatory Bowel Diseases*/chemically induced , Inflammatory Bowel Diseases*/etiology , Inflammatory Bowel Diseases*/immunology , Inflammatory Bowel Diseases*/pathology , Intestines*/drug effects , Intestines*/immunology , Intestines*/metabolism , Intestines*/pathology , Herbicides*/adverse effects , Environment*, Animals ; Mice ; Zebrafish ; Machine Learning ; Databases, Factual ; Disease Models, Animal ; NF-kappa B ; CCAAT-Enhancer-Binding Protein-beta ; Receptors, Aryl Hydrocarbon ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Dendritic Cells/metabolism |
| مستخلص: | Genome-wide association studies have identified risk loci linked to inflammatory bowel disease (IBD) 1 -a complex chronic inflammatory disorder of the gastrointestinal tract. The increasing prevalence of IBD in industrialized countries and the augmented disease risk observed in migrants who move into areas of higher disease prevalence suggest that environmental factors are also important determinants of IBD susceptibility and severity 2 . However, the identification of environmental factors relevant to IBD and the mechanisms by which they influence disease has been hampered by the lack of platforms for their systematic investigation. Here we describe an integrated systems approach, combining publicly available databases, zebrafish chemical screens, machine learning and mouse preclinical models to identify environmental factors that control intestinal inflammation. This approach established that the herbicide propyzamide increases inflammation in the small and large intestine. Moreover, we show that an AHR-NF-κB-C/EBPβ signalling axis operates in T cells and dendritic cells to promote intestinal inflammation, and is targeted by propyzamide. In conclusion, we developed a pipeline for the identification of environmental factors and mechanisms of pathogenesis in IBD and, potentially, other inflammatory diseases. (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.) |
| التعليقات: | Comment in: Nat Rev Immunol. 2022 Dec;22(12):718. (PMID: 36357705) |
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| معلومات مُعتمدة: | R01 MH130458 United States MH NIMH NIH HHS; R01 ES032323 United States ES NIEHS NIH HHS; R01 ES025530 United States ES NIEHS NIH HHS; K99 NS114111 United States NS NINDS NIH HHS; R01 AI126880 United States AI NIAID NIH HHS; T32 GM007356 United States GM NIGMS NIH HHS; T32 DK007356 United States DK NIDDK NIH HHS; K12 CA090354 United States CA NCI NIH HHS; R56 AI093903 United States AI NIAID NIH HHS; R21 NS087867 United States NS NINDS NIH HHS; R01 AI093903 United States AI NIAID NIH HHS; R00 NS114111 United States NS NINDS NIH HHS; F32 NS101790 United States NS NINDS NIH HHS; T32 CA207021 United States CA NCI NIH HHS |
| المشرفين على المادة: | 2EZ95375S0 (pronamide) 0 (Ahr protein, mouse) 0 (NF-kappa B) 0 (Cebpb protein, mouse) 0 (CCAAT-Enhancer-Binding Protein-beta) 0 (Receptors, Aryl Hydrocarbon) 0 (Herbicides) |
| تواريخ الأحداث: | Date Created: 20221020 Date Completed: 20221130 Latest Revision: 20230426 |
| رمز التحديث: | 20230427 |
| مُعرف محوري في PubMed: | PMC9898826 |
| DOI: | 10.1038/s41586-022-05308-6 |
| PMID: | 36266581 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1038/s41586-022-05308-6 |