دورية أكاديمية
Transcriptional activation of Mink enteritis virus VP2 by the C-terminal of its NS1 protein.
| العنوان: | Transcriptional activation of Mink enteritis virus VP2 by the C-terminal of its NS1 protein. |
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| المؤلفون: | Xie Q; State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China., Wang J; State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China., Liu Y; State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China., Su J; State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China., Gu C; State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China., Wu J; State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China., Xiao J; Department of Geriatrics, the Eight Medical Centre, Chinese PLA General Hospital, Beijing, China. xxxjjj6288@sina.com., Liu W; State Key Laboratory of Agrobiotechnology, Department of Biochemistry and Molecular Biology, College of Biological Sciences, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing, 100193, China. weiquan8@cau.edu.cn. |
| المصدر: | Virus genes [Virus Genes] 2023 Feb; Vol. 59 (1), pp. 100-108. Date of Electronic Publication: 2022 Oct 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: United States NLM ID: 8803967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-994X (Electronic) Linking ISSN: 09208569 NLM ISO Abbreviation: Virus Genes Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Boston Ma : Kluwer Academic Original Publication: Boston, USA : M. Nijhoff, 1987- |
| مواضيع طبية MeSH: | Mink enteritis virus*/genetics , Mink enteritis virus*/metabolism, Animals ; Transcriptional Activation ; Promoter Regions, Genetic ; Base Sequence ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Protein Binding ; Mink/genetics |
| مستخلص: | Mink enteritis virus (MEV) NS1 is a multidomain and multifunctional protein containing origin binding, helicase, and transactivation domains. In particular, parvoviral NS1 proteins are transactivators of the viral capsid protein promoter although the manner by which they exert these transactivation effects remained unclear. In this study, the region of the transactivation domain of the NS1 C-terminal was found located at aa 557 ~ 668 and any deletion within this region reduced the transactivation activity. A dominant negative mutation of the 63 aa deletion in the C-terminal of NS1 protein resulted in loss of ability to activate P38 and VP2-5'UTR in a dual-luciferase reporter assay system, a VP2 protein expression system, and within the whole MEV genome, independent of downstream genes. Additionally, a full-length MEV clone deficient in its NS1 C-terminal failed to rescue the virus, possibly due to the loss of integrity of DNA sequences interacting with NS1 protein, and expression of VP2 was also inhibited even when normal NS1 protein was supplied in trans. (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| معلومات مُعتمدة: | 2016YFD0501001 National Key Research and Development Program of China |
| فهرسة مساهمة: | Keywords: NS1; P38 promoter; Transactivation; VP2; VP2-5′UTR |
| المشرفين على المادة: | 0 (Viral Nonstructural Proteins) |
| تواريخ الأحداث: | Date Created: 20221022 Date Completed: 20230112 Latest Revision: 20230112 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s11262-022-01947-z |
| PMID: | 36272032 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1572-994X |
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| DOI: | 10.1007/s11262-022-01947-z |