دورية أكاديمية
Bioassay guided fractionation, isolation and characterization of hepatotherapeutic 1, 3-di-ortho-galloyl quinic acid from the methanol extract of the leaves of Pterocarpus santalinoides.
| العنوان: | Bioassay guided fractionation, isolation and characterization of hepatotherapeutic 1, 3-di-ortho-galloyl quinic acid from the methanol extract of the leaves of Pterocarpus santalinoides. |
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| المؤلفون: | Ihedioha TE; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria. Electronic address: thelma.ihedioha@unn.edu.ng., Asuzu IU; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria., Anaga AO; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria., Ihedioha JI; Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria., Nnadi CO; Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2023 Jan 30; Vol. 301, pp. 115864. Date of Electronic Publication: 2022 Oct 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Pterocarpus*/chemistry, Rats ; Biological Assay ; Methanol ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Plant Leaves ; Quinic Acid ; Animals |
| مستخلص: | Ethnopharmacological Relevance: Leaf extracts of Pterocarpus santalinoides DC are traditionally used to ameliorate ageing-related ailments such as heart and liver diseases, and have been reported to be protective against toxic injuries to the liver. Aim of the Study: This study aimed to isolate and characterize the hepatoprotective/hepatotherapeutic principle in the methanol leaf extract of P. santalinoides. Materials and Methods: Fresh leaves of P. santalinoides were dried under shade and ground into powder. The ground leaves (2 Kg) were extracted with 80% methanol by maceration. Fractionation was carried out using column and thin layer chromatography techniques. Bioassay of fractions and sub-fractions was done using carbon tetrachloride (CCl Results: Extraction yielded 260 g dry extract. Six fractions (F1, F2, F3, F4, F5 and F6) were obtained after column and thin layer chromatography, with F6 (R Conclusion: The hepatoprotective/hepatotherapeutic principle in the methanol extract of the leaves of P. santalinoides was identified as 1, 3-di-ortho-galloyl quinic acid. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 1; 3-di-ortho-galloyl quinic acid; Characterization; Hepatotherapeutic principle; Isolation; Methanol leaf extract; Pterocarpus santalinoides |
| المشرفين على المادة: | Y4S76JWI15 (Methanol) 0 (Plant Extracts) 058C04BGYI (Quinic Acid) |
| تواريخ الأحداث: | Date Created: 20221025 Date Completed: 20230719 Latest Revision: 20230719 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jep.2022.115864 |
| PMID: | 36283637 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2022.115864 |